Sensory alien hand syndrome in corticobasal degeneration: A cerebral blood flow study

Delrieu, Julien; Payoux, Pierre; Toulza, Olivier; Esquerré, J. P.; Vellas, Bruno; Voisin, Thierry

doi:10.1002/mds.23064

Cited by 11 publications

(14 citation statements)

References 12 publications

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“…Interestingly, three of the seven patients with CBS had AHS, and these also had reductions in the right thalamus, supramarginal gyrus, and the posterior cingulate gyrus. 32 …”

Section: Resultsmentioning

confidence: 99%

Pathophysiology and Treatment of Alien Hand Syndrome

Sarva,

Deik,

Severt

2014

Tremor and Other Hyperkinetic Movements

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“…Interestingly, three of the seven patients with CBS had AHS, and these also had reductions in the right thalamus, supramarginal gyrus, and the posterior cingulate gyrus. 32 …”

Section: Resultsmentioning

confidence: 99%

Pathophysiology and Treatment of Alien Hand Syndrome

Sarva,

Deik,

Severt

2014

Tremor and Other Hyperkinetic Movements

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“…Ces résultats sont en accord avec les données de la littérature. En revanche, nous n'avons pas observé d'hypoperfusion sous-corticale, thalamique et/ou des ganglions de la base, pourtant décrite dans la littérature [41,42,44,46,[49][50][51]. Peu d'études dans la littérature ont exploré le profil lésionnel en fonction du profil neuropathologique sous-jacent.…”

Section: Discussionunclassified

“…En TEMP de perfusion cérébrale, différentes études mettent en évidence une perfusion asymétrique [41][42][43][44][45][46][47][48] avec des hypoperfusions régionales d'étendue variable, concernant le cortex fronto-pariétal [41][42][43]46,49,50], en particulier péri-rolandique [50], parfois le cortex temporal [41,44,46,47,49], les ganglions de la base et le thalamus [41,42,44,46,[49][50][51].…”

Section: Critères Nécessairesunclassified

Apport de la scintigraphie de perfusion cérébrale dans l’exploration du syndrome cortico-basal

et al. 2015

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“…Imaging acquisition and reconstruction was carried out with the usual specified protocols (Delrieu et al, 2010). …”

Section: Methodsmentioning

confidence: 99%

When Playing Is a Problem: An Atypical Case of Alien Hand Syndrome in a Professional Pianist

Alfaro

Bernabéu²,

Badesa

et al. 2017

Front. Hum. Neurosci.

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Alien hand syndrome (AHS) is a neurological illness characterized by limb movements which are carried out without being aware of it. Many patients describe these movements as aggressive and some perceive a strong feeling of estrangement and go so far as to deny ownership. The sense of body ownership is the perception that parts of one’s body pertain to oneself, despite it is moving or not and if movement is intentional or unintentional. These anomalous self-experiences may arise in patients with focal brain lesions and provide unique opportunities to disclose the neural components underlying self-body perception. The feeling of foreignness described in AHS is often observed in post-central cortical lesions in the non-dominant hemisphere and is typical of the “posterior alien hand variant”. We used Diffusion-Tensor magnetic resonance imaging (DT-MRI) in an unusual case of posterior AHS of the dominant hand in a professional pianist with corticobasal syndrome (CBS). The patient showed uncontrolled levitation with the right arm while playing the piano and perceived as if her hand had a “mind of its own” which prevented her from playing. MRI-scans show asymmetric brain atrophy, mainly involving left post-central regions and SPECT-Tc99m-ECD patterns of hypometabolism over the left parietal-occipital cortices. DT-MRI revealed extensive damage which comprised left fronto-temporal cortex and extends into the ipsilateral parietal cortex causing a disruption of corpus callosum (CC) projections from the rostrum to the splenium. Our case illustrates that posterior AHS may occur in the dominant hemisphere due to widespread damage, which exceed parietal cortex. The parietal lobe has been recognized as a multimodal association region that gets input from several networks and organizes motor output. We suggest that the disturbance to this pathway could result in disruption of motor output and associate an abnormal motor control and anomalous self-body perception.

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Sensory alien hand syndrome in corticobasal degeneration: A cerebral blood flow study

Cited by 11 publications

References 12 publications

Pathophysiology and Treatment of Alien Hand Syndrome

Pathophysiology and Treatment of Alien Hand Syndrome

Apport de la scintigraphie de perfusion cérébrale dans l’exploration du syndrome cortico-basal

When Playing Is a Problem: An Atypical Case of Alien Hand Syndrome in a Professional Pianist

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