Sensory Action Potentials of the Median and Ulnar Nerves in Aged Persons

Drechsler, F.

doi:10.1159/000395788

Cited by 5 publications

(8 citation statements)

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“…In healthy elderly subjects, the reduction in SNAP amplitude is more marked in digits innervated by median, ulnar, and radial nerve. These results agree with those of Dreschler 17 and Cruz.…”

Section: Discussionsupporting

confidence: 93%

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Nerve Conduction study in healthy individuals, a preliminary age based study

Thakur

Paudel

Jha

2012

Kathmandu Univ. Med. J.

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Section: Discussionsupporting

confidence: 93%

“…17 Falco et al in their study also reported the statistically significant effect of age on SNAP amplitudes. 7 SNAP durations were longer in older age group as compared to the younger ones in most of the nerves, but was statistically significant in some of them.…”

Section: Discussionmentioning

confidence: 77%

Nerve Conduction study in healthy individuals, a preliminary age based study

Thakur

Paudel

Jha

2012

Kathmandu Univ. Med. J.

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“…In healthy adults the reduction in amplitude is more marked in digits innervated by the median than by the ulnar nerve, and the ratio between digits 5: 3 increases in elderly subjects. These results agree with those of Dreschler (1975), and the preferential involvement of the median nerve in the elderly could be explained by a chronic compression in the carpal tunnel, and by a higher sensitivity to anoxia of the median nerve of the limbs of older people (Dreschler, 1975). These results also agree with the conclusions of Cruz Martinez et al (1978b), and suggest that age causes changes particularly in the points where the nerves are more frequently compressed.…”

Section: Discetssioinsupporting

confidence: 88%

“…It has been necessary to assume a fixed sensory segmental innervation of the hands, and to calculate the normal ratio in amplitude between the different fingers. This ratio can change according to the age of the subject (Dreschler, 1975).…”

mentioning

confidence: 99%

Electrophysiological aspects of sensory conduction velocity in healthy adults. 2. Ratio between the amplitude of sensory evoked potentials at the wrist on stimulating different fingers in both hands.

Martínez¹,

Barrio²,

Conde³

et al. 1978

Journal of Neurology, Neurosurgery & Psychiatry

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S U M M ARY The normal ratio between the amplitude of the sensory evoked potential (SEP) at the wrist on stimulating digits 1, 2, 3, and 5 was determined in 44 healthy adult subjects. The first digit had the larger amplitude, and the fifth digit the smallest SEP. The amplitude expresses the density of sensory innervation in each finger. The ratio between the amplitude of different fingers varied according to the age of the subject. The amplitude of the SEP from a digit innervated by the median nerve decreased in the elderly more than the SEP amplitude of the digit innervated by the ulnar nerve, probably because of a chronic compression in the carpal tunnel. The changes in the normal amplitude ratio can be applied to the topographic diagnosis of radicular and brachial plexus lesions if a fixed segmental sensory innervation of the hand is accepted. In 44 right handed subjects the amplitude of the sensory evoked potentials at the wrist was significantly larger in the left hand. This asymmetry of sensory innervation between hands could be physiological, and suggests a greater density of sensory innervation in the left hand of right handed subjects.

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“…Morphologic studies have reported an altered myelination (e.g., demyelination, myelin balloon figures) in various peripheral nerves in elderly participants, which might be caused by a decrease in expression of the major myelin proteins (Verdu et al, 2000). Moreover, a reduction in nerve conduction velocity of peripheral nerves is a well-documented finding in elderly animals (e.g., see Chase et al, 1992) as well as human beings (e.g., see Drechsler, 1975). Based on these findings, it might be speculated that age-associated degenerative processes targeting the myelination of either auricular nerve or vagus fibers in the brainstem are responsible for the highly significantly increased latencies.…”

Section: Discussionmentioning

confidence: 99%