Sensory Acquisition in the Cerebellum: An fMRI Study of Cerebrocerebellar Interaction During Visual Duration Discrimination

Shih, Lynn Y.L.; Chen, Li Fen; Kuo, Wen Jui; Yeh, Ta‐Chuan; Wu, Yu Te; Tzeng, Ovid J.L.; Hsieh, Jen Chuen

doi:10.1007/s12311-008-0082-4

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…More recently, the cerebellum has also been implicated in social, cognitive, and emotional functions (Bauman and Kemper 2005). Shih et al (2008) showed that the cerebellum plays a critical role in sensory acquisition and discrimination.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Therapeutic Horseback Riding on Social Functioning in Children with Autism

Bass

Duchowny

Llabre

2009

J Autism Dev Disord

343

277

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This study evaluated the effects of therapeutic horseback riding on social functioning in children with autism. We hypothesized that participants in the experimental condition (n = 19), compared to those on the wait-list control (n = 15), would demonstrate significant improvement in social functioning following a 12-weeks horseback riding intervention. Autistic children exposed to therapeutic horseback riding exhibited greater sensory seeking, sensory sensitivity, social motivation, and less inattention, distractibility, and sedentary behaviors. The results provide evidence that therapeutic horseback riding may be a viable therapeutic option in treating children with autism spectrum disorders.

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Section: Discussionmentioning

confidence: 99%

The Effect of Therapeutic Horseback Riding on Social Functioning in Children with Autism

Bass

Duchowny

Llabre

2009

J Autism Dev Disord

343

277

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“…It has been proposed that, due to its uniform neuro-architecture with closed input–output loops that connect cerebellum and cerebrum (Middleton and Strick 1994; Strick et al 2009), the cerebellum also possesses uniform processing habits to enable overarching, domain-independent functions such as monitoring, coordination, and timing (Strick et al 2009). Along these lines, the cerebellum may also provide other basic functions such as sensory acquisition (Gao et al 1996; Bower 1997; Shih et al 2009), internal modelling/error correction (Wolpert et al 1998; Ito 2008), performance monitoring (Peterburs and Desmond 2016), and sequence detection (Braitenberg et al 1997; Molinari et al 2008; Leggio and Molinari 2015; Tedesco et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Cerebellar contributions to sequence prediction in verbal working memory

et al. 2018

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Verbal working memory is one of the most studied non-motor functions with robust cerebellar involvement. While the superior cerebellum (lobule VI) has been associated with articulatory control, the inferior cerebellum (lobule VIIIa) has been linked to phonological storage. The present study was aimed to elucidate the differential roles of these regions by investigating whether the cerebellum might contribute to verbal working memory via predictions based on sequence learning/detection. 19 healthy adult subjects completed an fMRI-based Sternberg task which included repeating and novel letter sequences that were phonologically similar or dissimilar. It was hypothesized that learning a repeating sequence of study letters would reduce phonological storage demand and associated right inferior cerebellar activations and that this effect would be modulated by phonological similarity of the study letters. Specifically, while increased phonological storage demand due to high phonological similarity was expected to be reflected in increased right inferior cerebellar activations for similar relative to dissimilar study letters, the reduction in activation for repeating relative to novel sequences was expected to be more profound for phonologically similar than for dissimilar study letters, especially at higher memory load. Results confirmed the typical effects of cognitive load (5 vs. 2 study letters) and phonological similarity in several cerebellar and neocortical brain regions as well as in behavioral data (accuracy and response time). Importantly, activations in superior and inferior cerebellar regions were differentially modulated as a function of similarity and sequence novelty, indicating that particularly lobule VIIIa may contribute to verbal working memory by generating predictions of letter sequences that reduce the likelihood of phonological loop failure before stored items need to be retrieved. The present study is consistent with other investigations that support prediction, which can be based on sequence learning or detection, as an overarching cerebellar function. Electronic supplementary material The online version of this article (10.1007/s00429-018-1784-0) contains supplementary material, which is available to authorized users.

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“…Put another way, the cerebellum may be more "motor for sensory sake," than "sensory for motors sake" . Evidence consistent with such a role has now been obtained from human subjects performing tactile (Gao et al 1996), olfactory (Sobel et al 1998), visual (Baumann and Mattingley 2010;Shih et al 2009Shih et al , 2010, and auditory (Petacchi et al 2005(Petacchi et al , 2011 sensory discriminations.…”

Section: A New Cortical Computational Algorithmmentioning

confidence: 67%

Computational Structure of the Cerebellar Molecular Layer

Bower¹

2013

Handbook of the Cerebellum and Cerebellar Disorders

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Theories regarding the computational structure of the cerebellar molecular layer have been more strongly influenced by biological data than is the case for many and perhaps even most other vertebrate brain regions. Yet, or perhaps for this reason, the computational significance of this circuitry remains a very active subject of discussion and debate, with even basic assumptions regarding the physiological organization of this circuit now being questioned. Specifically, while most current models of molecular layer circuitry assume that parallel fiber excitatory synaptic input directly drives Purkinje cells to fire, there is growing experimental evidence that this might not be the case. Recent model-based efforts to better understand the functional role of the parallel fiber system suggest that molecular layer inhibition may play a larger and more complex physiological role than previously realized. In turn, this reanalysis of the role of inhibition in cerebellar cortical circuitry suggests that the cerebellar molecular layer may implement a sensory-related contextual algorithm, rather than either a timing or associative learning function previously assumed to provide the basis for a cerebellar involvement in motor coordination.

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Sensory Acquisition in the Cerebellum: An fMRI Study of Cerebrocerebellar Interaction During Visual Duration Discrimination

Cited by 12 publications

References 56 publications

The Effect of Therapeutic Horseback Riding on Social Functioning in Children with Autism

The Effect of Therapeutic Horseback Riding on Social Functioning in Children with Autism

Cerebellar contributions to sequence prediction in verbal working memory

Computational Structure of the Cerebellar Molecular Layer

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