Sensors for determination of uranium: A review

Wu, Xumeng; Huang, Qiuxiang; Mao, Yu; Wang, Xiangxue; Wang, Yuyuan; Hu, Qinghua; Wang, Hongqing; Wang, Xiangke

doi:10.1016/j.trac.2019.04.026

Cited by 98 publications

(36 citation statements)

References 242 publications

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“…Based on this knowledge, model peptides could be rationally designed as uranyl sensors with high selectivity and binding affinity [35,36]. Owing to the unique cleavage property of uranyl ions, various uranyl-specific DNAzymes have been developed for biomedical and environmental applications [96,97]. Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the DNAzyme-AuNP probe can be modified to readily enter living cells, where it serves as an intracellular uranyl ion sensor [96]. For more sensors for the determination of uranium, the readers are referred to an excellent recent review by Wang and co-workers [97]. Additionally, due to the complexity of chemical conditions in cells, UO 2 2+ itself may react with other chemicals, resulting in formation of uranyl particles [98].…”

Section: Protein/dna Cleavage and Other Impactsmentioning

confidence: 99%

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Uranyl Binding to Proteins and Structural-Functional Impacts

Lin

2020

Biomolecules

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The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO 2 2+ ). Although uranyl-protein/DNA interactions have been known for decades, fewer advances are made in understanding their structural-functional impacts. Instead of focusing only on the structural information, this article aims to review the recent advances in understanding the binding of uranyl to proteins in either potential, native, or artificial metal-binding sites, and the structural-functional impacts of uranyl-protein interactions, such as inducing conformational changes and disrupting protein-protein/DNA/ligand interactions. Photo-induced protein/DNA cleavages, as well as other impacts, are also highlighted. These advances shed light on the structure-function relationship of proteins, especially for metalloproteins, as impacted by uranyl-protein interactions. It is desired to seek approaches for biological remediation of uranyl ions, and ultimately make a full use of the double-edged sword of uranium.Proteins, especially for metalloproteins, play vital roles in supporting life, including electron-transfer, O 2 -binding and delivery, and catalysis, etc [11][12][13][14][15][16][17][18]. To date, a plenitude of proteins have been shown to interact with UO 2 2+ , such as proteins in blood (human serum albumin, HSA; transferrin, Tf;hemoglobin, Hb), proteins involved in bone growth (osteopontin, OPN; fetuin-A), and the intracellar proteins (metallothionein, MT; cytochromes b 5 /c; Cyt b 5 /c; calmodulin, CaM), etc [19]. Although the structural features of some uranyl-protein complexes are well-documented [7-9], fewer advances are made in understanding the functional impacts of uranyl-protein interactions, with much less for other actinides-proteins interactions, as reviewed by Creff et al. very recently [20]. Instead of focusing only on the structural information, this review highlights the recent advances in understanding the binding of uranyl to proteins, as illustrated in Scheme 1, in either potential, native or artificial metal-binding sites, or the corresponding structural-functional impacts, such as inducing conformational changes and disrupting protein-protein/DNA/ligand interactions. Future directions for studying uranyl-protein interactions are also prospected.

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Section: Discussionmentioning

confidence: 99%

Section: Protein/dna Cleavage and Other Impactsmentioning

confidence: 99%

Uranyl Binding to Proteins and Structural-Functional Impacts

Lin

2020

Biomolecules

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“…Generally, uranyl ions bind to proteins and lipids with sialic acid carboxyl groups, and to DNA and RNA by phosphate groups [ 11 ]. Therefore, the unique property of the uranyl ion as conformational changes for the structure of the biological molecule and a DNA cleavage estimated for biomedical and environmental applications [ 12 , 13 ]…”

Section: Introductionmentioning

confidence: 99%

Complexation of uranyl (UO2)2+ with bidentate ligands: XRD, spectroscopic, computational, and biological studies

et al. 2021

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Three new uranyl complexes [(UO2)(OAc)2(CMZ)], [(UO2)(OAc)2(MP)] and [(UO2)(OAc)2(SCZ)] were synthesized and characterized by elemental analysis, FT-IR, UV-Vis spectroscopy, powder XRD analysis, and molar conductivity. The IR analysis confirmed binding to the metal ion by the sulfur and ethoxy oxygen atoms in the carbimazole (CMZ) ligand, while in the 6-mercaptopurine (MP) ligand, the sulfur and the N7 nitrogen atom of a purine coordinated binding to the metal ion. The third ligand showed a 1:1 molar ratio and bound via sulfonamide oxygen and the nitrogen of the pyrimidine ring. Analysis of the synthesized complexes also showed that acetate groups had monodentate binding to the (UO22+). Density Functional Theory (DFT) calculations at the B3LYP level showed similar structures to the experimental results. Theoretical quantum parameters predicted the reactivity of the complexes in the order, [(UO2)(OAc)2(SCZ)] > [(UO2)(OAc)2(MP)]> [(UO2)(OAc)2(CMZ)]. DNA binding studies revealed that [(UO2)(OAc)2(SCZ)] and [(UO2)(OAc)2(CMZ)] have the highest binding constant (Kb) among the uranyl complexes. Additionally, strong binding of the MP and CMZ metal complexes to human serum albumin (HSA) were observed by both absorbance and fluorescence approaches. The antibacterial activity of the complexes was also evaluated against four bacterial strains: two gram-negative; Escherichia coli and Klebsiella pneumonia, and two gram-positive; Staphylococcus aureus and Streptococcus mutans. [(UO2)(OAc)2(MP)] had the greatest antibacterial activity against Klebsiella pneumonia, the gram-positive bacteria, with even higher activity than the standard antibiotic. In vitro cytotoxicity tests were also performed against three human cancer lines, and revealed the most cytotoxic complexes to be [(UO2)(OAc)2(SCZ)], which showed moderate activity against a colon cancer cell line. Thus, uranyl addition enhances the antibacterial and anticancer properties of the free ligands.

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“…Although suspended mercury droplets and mercury film electrodes have been used for AdSV determination of uranium, the biological toxicity of mercury has increased people's interest in non‐mercury sensors [20] . For this purpose, new electrode materials and methods for measurement of uranium have been developed, such as modified carbon paste electrodes, [21] self‐assembled monolayer gold‐based electrodes, [22] carbon nanotube modified electrodes, [23] screen‐printed electrodes, [24] carbon fiber electrodes, [25] and graphite electrodes [26] …”

Section: Introductionmentioning

confidence: 99%

Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions

Wang

Liu

et al. 2021

Zeitschrift anorg allge chemie

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The rapid development of the nuclear industry has gradually aroused people′s attention to the problem of nuclear pollution. Due to the biological toxicity of uranium and its aqueous solution, simple and rapid detection of uranium in the water environment is quite important. An ion imprinted carbon nanomaterial (graphene oxide) electrochemical sensor for the detection of trace uranyl ions was prepared by using the synthesized bipolar tetradentate macrocyclic uranyl ligand cyclo‐bis‐phenylenediamine‐bis‐(phenylmethyl‐diphyrrolecarbaldehyde) (H4L) as functional monomer. The sol‐gel polymer was prepared by hydrolysis and polymerization of H4L ligand, 3‐aminopropyltrimethoxysilane and tetraethoxysilane. H4L‐ion imprinted polymer (U‐IIP) was prepared by adding 1 mM uranyl ion as template ions. Then the polymer was bonded to graphene oxide modified carbon paste electrode, and the template ions were eluted to obtain H4L‐ion imprinted‐graphene oxide modified carbon paste electrode (U‐IIP/GO/CPE). Differential pulse voltammetry was used to detect trace uranyl ions. The results showed that the U‐IIP/GO/CPE sensor system can detect uranyl ions with high sensitivity and specificity, and the peak current appeared around −0.26v. In the range of 0.01 μM∼3.0 μM, the detection current had a good linear relationship with the molar concentration of uranyl ions, and the method detection limit was 1.32 nM (S/N=3). Through the detection of actual samples, it had a good acceptable recovery rate (95.45 %∼106.25 %), and the relative standard deviation was less than 3.25 %.

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Sensors for determination of uranium: A review

Cited by 98 publications

References 242 publications

Uranyl Binding to Proteins and Structural-Functional Impacts

Uranyl Binding to Proteins and Structural-Functional Impacts

Complexation of uranyl (UO2)2+ with bidentate ligands: XRD, spectroscopic, computational, and biological studies

Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions

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Sensors for determination of uranium: A review

Cited by 98 publications

References 242 publications

Uranyl Binding to Proteins and Structural-Functional Impacts

Uranyl Binding to Proteins and Structural-Functional Impacts

Complexation of uranyl (UO2)2+ with bidentate ligands: XRD, spectroscopic, computational, and biological studies

Graphene oxide modified H4L‐ion imprinting electrochemical sensor for the detection of uranyl ions

Contact Info

Product

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Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions