Sensors for Catheter Applications

French, P.J.; Tanase, Stéfania; Goosen, J.F.L.

doi:10.1002/seup.200390018

Cited by 18 publications

(11 citation statements)

References 107 publications

(97 reference statements)

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“…Catheters with the aid of sensing technologies can be used for real-time sensing and monitoring of flow, temperature, pressure, and biomolecules in the body [24] . For example, Li et al .…”

Section: Technologies and Materials In Delivering And Monitoring Regenerative Therapeuticsmentioning

confidence: 99%

Minimally Invasive and Regenerative Therapeutics

et al. 2018

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Advances in biomaterial synthesis and fabrication, stem cell biology, bioimaging, microsurgery procedures, and microscale technologies have made minimally invasive therapeutics a viable tool in regenerative medicine. Therapeutics, herein defined as cells, biomaterials, biomolecules, and their combinations, can be delivered in a minimally invasive way to regenerate different tissues in the body, such as bone, cartilage, pancreas, cardiac, skeletal muscle, liver, skin, and neural tissues. Sophisticated methods of tracking, sensing, and stimulation of therapeutics in vivo using nanobiomaterials and soft bioelectronic devices provide great opportunities to further develop minimally invasive and regenerative therapeutics (MIRET). In general, minimally invasive delivery methods offer high yield with low risk of complications and reduced costs compared to conventional delivery methods. Here, we review minimally invasive approaches for delivering regenerative therapeutics into the body. The use of MIRET to treat different tissues and organs is described. Although some clinical trials have been done using MIRET, it is hoped that such therapeutics find wider applications to treat patients. Finally, we highlight some future perspective and challenges for this emerging field.

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“…Catheters with the aid of sensing technologies can be used for real-time sensing and monitoring of flow, temperature, pressure, and biomolecules in the body [24] . For example, Li et al .…”

Section: Technologies and Materials In Delivering And Monitoring Regenerative Therapeuticsmentioning

confidence: 99%

Minimally Invasive and Regenerative Therapeutics

et al. 2018

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“…[1][2][3][4][5][6][7][8][9][10] Another important application for in vivo electronics is sensors and MEMS on catheters, allowing sensory feedback to the operator or manipulation of a MEMS device internally. 11,12 Micro in vivo electronic sensors also offer a means of less invasive direct monitoring by wireless transmission or aid efficient pharmaceutical release. 13 Non-toxic, non-allergenic and inert gold and platinum can be used as electrode materials; however toxins and allergens should be avoided in fabrication.…”

mentioning

confidence: 99%

Direct Gold Plating Selectively on UV Modified Polymer Film Using Tiopronin-Gold

Endo

Tashiro

et al. 2015

J. Electrochem. Soc.

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An economic and low toxicity gold plating process for bio-compatible device fabrication was investigated. A tiopronin-gold complex altered by mercaptothiodiazole or mercaptotriazole derivatives gave a form of the complex that could be reduced autocatalytically to enable electroless gold plating. Catalytic ca. 5 nm gold particles were selectively grafted into cycloolefin polymer and polyethylenenaphthalate film surfaces by adsorption of tiopronin-gold complex from solution into 20-30 nm deep ultra-violet light modified surface layers followed by reduction with sodium borohydride. Exposure of the catalyst adsorbed surfaces to baths composed of tiopronin-gold complex, mercaptothiodiazole and ascorbic acid resulted in selective electroless plating on the modified surfaces. Observation of the interface cross-section by transmission electron microscopy revealed that the gold deposits were physically anchored to the substrate by nanometer scale octopus trap like structures. Bio-compatible electronics for in vivo application represent an innovative field of medicine, offering ailment for life quality debilitating health complications. In the applications, sensors and transducers read or relay electronic input or output directly to or from living biological systems, like the brain. In retinal and cochlear neuroprosthesis, neural array implants facilitate direct stimulation of optic nerves with signals from a miniature camera, or direct stimulation of cochlear nerves with signals from a microphone. Research involving conscious neural control to operate external devices like prosthetic robots has also been undertaken. Neural electrode arrays also serve in therapeutic stimulation, bypass or diagnosis of specific neural systems in stroke and head injury patients and in patients suffering from Parkinson's disease, epilepsy, dystonia and severe clinical depression.1-10 Another important application for in vivo electronics is sensors and MEMS on catheters, allowing sensory feedback to the operator or manipulation of a MEMS device internally.11,12 Micro in vivo electronic sensors also offer a means of less invasive direct monitoring by wireless transmission or aid efficient pharmaceutical release. 13Non-toxic, non-allergenic and inert gold and platinum can be used as electrode materials; however toxins and allergens should be avoided in fabrication. Economic plating techniques that rely on bath components and construction materials that are toxic or allergenic introduce health risks and are therefore difficult to implement in fabrication. One approach for deposition of biocompatible gold patterns on poly(dimethylsiloxane) has been described using chemical plating and electrochemical etching. 14 In medicine, tiopronin (TPN) has been used therapeutically as a treatment of cystine disulfide related ailments like cystinuria and prophylaxis of renal cystine calculi, functioning based on an increase in solubility. 15,16 Tiopronin capped gold nanoclusters/nanoparticles (TPN-AuNP) have also been a center of attention in a broad spectrum...

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“…Furthermore, small catheter incision ports limit the size of the device that may be inserted, thereby limiting the ability to use larger artificial sensory systems. Miniaturized sensors can provide both precise information about location and biochemical diagnostic information to improve the efficiency of operations and open new possibilities to treat more medical problems using catheterization (French et al 2003;Haga and Esashi 2004;Li et al 2005a, b;Goosen 2002). For optimal diagnosis and treatment, many of the parameters need to be measured and normally these parameters are strongly linked to therapeutic outcome.…”

Section: Introductionmentioning

confidence: 98%

A flexible polymer tube lab-chip integrated with microsensors for smart microcatheter

Han

et al. 2008

Biomed Microdevices

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A flexible polymer tube lab-chip integrated with physical and biochemical sensor modules mounted on a flexible spiral structure for measuring physiological (temperature/flow rate) and metabolic data (glucose concentration) in a catheter application was designed, fabricated and characterized in this work. This new approach not only provides a unique way to assemble multiple sensors on both the inside and outside the flexible polymer tube using standard microfabrication methods while avoiding wiring and assembling problems associated with previous methods, but also maintains catheter inherent lumen potency for in situ drug delivery or insertion of medical tools. Three well-known sensors: temperature sensor (RTD), flow rate sensor (hot film anemometry) and glucose biosensor (amperometric sensor) have been successfully fabricated and fully integrated outside the spirally rolled polymer tube (ID = 500 microm, OD = 650 microm) of this demonstration device. The fabricated sensors showed good performances not only in a planar configuration but also in a spirally rolled configuration. This flexible micro tube lab-chip system provides a generic platform for developing patient-specific "smart" microcatheters that incorporate microsensors, microactuators, microfluidic devices and wireless signal communication modules that are tailored for the patients' unique condition.

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Sensors for Catheter Applications

Cited by 18 publications

References 107 publications

Minimally Invasive and Regenerative Therapeutics

Minimally Invasive and Regenerative Therapeutics

Direct Gold Plating Selectively on UV Modified Polymer Film Using Tiopronin-Gold

A flexible polymer tube lab-chip integrated with microsensors for smart microcatheter

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