Sensorineural hearing loss in sickle cell anaemia – a United Kingdom study

Ajulo, S. O.; Osiname, A. I.; Myatt, H. M.

doi:10.1017/s0022215100124442

Cited by 34 publications

(32 citation statements)

References 15 publications

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“…This finding may suggest that better care may decrease the incidence of SNHL. In this study, we did not find an increase in the frequency of hearing loss with increasing age, a finding which was supported by Friedman et al 2 and Ajulo et al 12 This is in disagreement with others who did find an increased incidence of hearing loss with increasing age. 6 The relationship between SNHL and early occurrence of attacks was suggested by Odetoyinbo and Adekile, who found that more than 90% of those who developed SNHL had their first vaso-occlusive crisis before the age of five years.…”

Section: Discussioncontrasting

confidence: 95%

“…2,3,6,7,12,13 Our results of 19% are similar to the previous reports from Saudi Arabia (23.8%), 7 as well as from Nigeria (21.4%) 3 and Jamaica (21.7%). 6 Studies from developed countries revealed much lower frequency of this complication (12% in the US 2 and 13.5% in the UK 12 ). This finding may suggest that better care may decrease the incidence of SNHL.…”

Section: Discussionsupporting

confidence: 90%

“…This was supported by other studies. 12 No patient with SNHL in our study had suffered from CNS infarction in the past. These findings were suggestive of nonneural causes of SNHL in our patients.…”

Section: Discussionmentioning

confidence: 70%

“…There is a consensus in the various audiological studies that patients with SCA have a much higher incidence of SNHL than the rest of the population. 12 The frequency of this complication was variable, ranging from 12% to 29%. 2,3,6,7,12,13 Our results of 19% are similar to the previous reports from Saudi Arabia (23.8%), 7 as well as from Nigeria (21.4%) 3 and Jamaica (21.7%).…”

Section: Discussionmentioning

confidence: 99%

“…12 The frequency of this complication was variable, ranging from 12% to 29%. 2,3,6,7,12,13 Our results of 19% are similar to the previous reports from Saudi Arabia (23.8%), 7 as well as from Nigeria (21.4%) 3 and Jamaica (21.7%). 6 Studies from developed countries revealed much lower frequency of this complication (12% in the US 2 and 13.5% in the UK 12 ).…”

Section: Discussionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Homozygous Sickle Cell Disease in Qatif, Saudi Arabia

et al. 1996

Ann Saudi Med

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Sensorineural hearing loss (SNHL) is a known complication of sickle cell disease (SCD). There is a paucity of information on this problem in Saudi SCD patients. A prospective controlled study was conducted over 27 months in Qatif Central Hospital. One hundred patients with sickle cell anemia (SCA), aged five to 40 years, were studied. The control group consisted of 100 healthy individuals. A detailed history, otologic and audiologic examinations were carried out on both groups. Further investigations to rule out local retrocochlear pathology were performed on those having unilateral SNHL. No case of SNHL was detected in the control group, while it was recorded in 19 (19%) of SCA patients, 13 males and six females. There was a significant association between the SNHL and the onset of first vaso-occlusive crisis at six years of age or less. There was no significant difference in the frequency of SNHL between children and adults. Twenty-one percent of patients who had SNHL completely recovered. Patients with SCD need a careful regular hearing assessment. Those detected to have SNHL need a careful plan implemented by both the clinician and otolaryngologist for proper care of this important complication.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sensorineural Hearing Loss in Homozygous Sickle Cell Disease in Qatif, Saudi Arabia

et al. 1996

Ann Saudi Med

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Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Okbi¹,

Alkindi²,

Al-Abri³

et al. 2011

The Laryngoscope

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The study reveals a significant incidence of sensorineural hearing loss (SNHL) in SCD patients (36.95%), although the patients were clinically asymptomatic. The hearing loss was worse in the right ears and had a female preponderance. Also, the hearing loss was more severe at the higher frequencies, 2,000-8,000 Hz in SCD patients. HbS, HbF, or low hemoglobin levels did not discriminate SCD patients with SNHL, and the role of hemoglobin F in the cochlea is still not clear. Regular audiometric assessment should therefore be recommended in SCD patients routinely.

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Prevalence and nature of hearing loss in a cohort of children with sickle cell disease

Towerman

Hayashi

et al. 2018

Pediatric Blood & Cancer

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Background: Sickle cell disease (SCD) may cause injury to any organ, including the auditory system. Although the association of SCD and hearing loss has been described, the nature of this complication is unknown. We sought to establish the prevalence and nature of hearing loss in a referred cohort of children with SCD and to identify correlating disease-or treatment-associated factors. Procedure:We conducted a retrospective review of patients with SCD < 22 years of age who had hearing evaluations between August 1990 and December 2014. Demographics, audiograms, and disease and treatment variables were analyzed.Results: Two hundred and ten audiograms among 81 patients were reviewed, and 189 were evaluable. Seventy-two children constituted the referred cohort. Fourteen (19.4%) had hearing loss documented on at least one audiogram. Seven (9.7%) patients had only conductive hearing loss, and the loss persisted for up to 10.3 years. The median age of first identification was eight years.Six (8.3%) patients had hearing loss that was at least partially sensorineural. One patient's hearing loss was ambiguous. All sensorineural hearing losses were unilateral and 4/6 patients had prior documented normal hearing, indicating acquired loss. No correlations were identified. Conclusions:Both conductive and sensorineural hearing losses are more prevalent in our study population than those observed in the general pediatric population. In children with SCD, sensorineural hearing loss appears to be acquired and unilateral. Conductive hearing loss was identified in older children and can persist. Serial screening is needed for early detection and more prompt intervention in this population.

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Sensorineural hearing loss in sickle cell anaemia – a United Kingdom study

Cited by 34 publications

References 15 publications

Sensorineural Hearing Loss in Homozygous Sickle Cell Disease in Qatif, Saudi Arabia

Sensorineural Hearing Loss in Homozygous Sickle Cell Disease in Qatif, Saudi Arabia

Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Prevalence and nature of hearing loss in a cohort of children with sickle cell disease

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