Sensorineural hearing loss in pediatric celiac patients

Hızlı, Şamil; Karabulut, Hayriye; Özdemir, Osman; Acar, Baran; Abacı, Ayhan; Dağlı, Muharrem; Karaşen, Rıza Murat

doi:10.1016/j.ijporl.2010.10.009

Cited by 23 publications

(18 citation statements)

References 31 publications

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“…Osteoporosis is associated with otosclerosis (Clayton et al 2004) – a common hearing disorder. Neutralizing autoantibodies against OPG cause the development of high-turnover osteoporosis in celiac disease (Riches et al, 2009), an autoimmune malabsorptive disorder of the small intestine associated with hearing loss (Hizli et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Kao¹,

Kempfle²,

Jensen³

et al. 2013

Neurobiology of Disease

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Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations and variations in the OPG gene cause many human diseases that are characterized by not only skeletal abnormalities but also poorly understood hearing loss: Paget’s disease, osteoporosis, and celiac disease. To gain insight into mechanisms of hearing loss in OPG deficiency, we studied OPG knockout (Opg −/−) mice. We show that they develop sensorineural hearing loss, in addition to conductive hearing loss due to abnormal middle-ear bones. OPG deficiency caused demyelination and degeneration of the cochlear nerve in vivo. It also activated ERK, sensitized spiral ganglion cells (SGC) to apoptosis, and inhibited proliferation and survival of cochlear stem cells in vitro, which could be rescued by treatment with exogenous OPG, an ERK inhibitor, or bisphosphonate. Our results demonstrate a novel role for OPG in the regulation of SGC survival, and suggest a mechanism for sensorineural hearing loss in OPG deficiency.

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Section: Introductionmentioning

confidence: 99%

Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss

Kao¹,

Kempfle²,

Jensen³

et al. 2013

Neurobiology of Disease

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“…In a subsequent study [12], the prevalence of SNHL among CD patients was 40.6%. However, none of the patients who exhibited findings consistent with SNHL had clinical hearing impairments, and the hearing dysfunction was detected mainly at low frequencies, i.e., 250 and 500 Hz.…”

Section: Discussionmentioning

confidence: 88%

“…However, none of the patients who exhibited findings consistent with SNHL had clinical hearing impairments, and the hearing dysfunction was detected mainly at low frequencies, i.e., 250 and 500 Hz. Since an insidious onset of hearing loss may have negative impacts on emotional, behavioral, cognitive, and sensorimotor development, early detection is important [33], and Hizli et al [12] have proposed that screening tests for hearing loss should be done at the time of diagnosis of pediatric CD.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study [10] has suggested that SNHL should also be regarded as a neurological symptom of CD, and the prevalence of subclinical SNHL in association with CD has been reported to be 8.5-47.1% [4,[10][11][12][13]. While there are a few published studies that assess the presence of SNHL among CD patients, the reliability of these studies has been controversial because of the small number of patients.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of hearing loss in pediatric celiac patients

Şahin¹,

Durucu²,

Şahin³

2015

International Journal of Pediatric Otorhinolaryngology

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“…Bir diğer 32 pediatrik ÇH ve 32 kontrol grubuyla farklı frekanslarda SNİK sıklığını ve şiddetini belirlemek amacıyla yapılan çalışmada ÇH ve SNİK arasında bir ilişki olduğunu düşündüren, sağlıklı kontrollere göre pediatrik çölyak hastalarında SNİK sıklığı yüksek saptanmıştır. Bu çalışmanın bulguları yeni tanı almış pediatrik ÇH hastalarda işitme kaybının aranması gerektiğini göstermektedir (9). Çölyak hastalığının otoantikorlarla ve otoimmün bozukluklarla ilişkisini saptamak amacıyla 59 ÇH hastası ve 59 kontrol grubu arasında yapılan bir diğer çalışmada hem odyometrik analiz hemde organ spesifik olmayan ve nörolojik otoantikorlarla ilişkisi araştırılmıştır.…”

Section: Discussionunclassified