Sensorineural hearing loss in patients reaching chronic renal failure in childhood

Mancini, Mario; Strologo, Luca Dello; Bianchi, P. E.; Tieri, L.; Rizzoni, Gianfranco

doi:10.1007/bf00863438

Cited by 47 publications

(55 citation statements)

References 15 publications

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“…[5] Mancini et al found no correlation between hearing loss, the duration of nephropathy and haemodialysis, suggesting that there must be another factor that caused hearing loss before treatment was started. [22] But in our study we found that mean duration of the disease and haemodialysis were strongly related with hearing loss group than in non-hearing loss group.…”

Section: Discussioncontrasting

confidence: 65%

“…[21] Though the role of dialysis is unclear, adverse factors possibly related to haemodialysis are acute hypotension, reduction in blood osmotic pressure, acute clearance of urea, increased red blood cell mass and immunologic reaction to dialyzer membranes. [22] Further, it has been proposed that long-term haemodialysis may cause electrolyte, osmotic and biochemical alterations leading to sensorineural hearing loss, [20] though a single session may not have significant effect on hearing. In a study by Erkoc et al, the mean duration of haemodialysis in the patient group with hearing loss was longer than that in the patient group without hearing loss.…”

Section: Discussionmentioning

confidence: 99%

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Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Acharya¹,

Pati²,

Nayak³

2017

jemds

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BACKGROUNDHearing loss in chronic kidney disease is believed to be of multifactorial aetiology. Associated hypertension and diabetes mellitus, use of ototoxic drugs, haemodialysis and the changes in metabolic parameters are the various reasons implicated in hearing loss. Also, the prevalence, degree and patterns of hearing loss associated with Chronic Kidney Disease (CKD) reported by various studies differ significantly.The current study was conducted to assess the degree and type of hearing loss in CKD patients and to find out the association of duration of disease, haemodialysis and certain blood parameters with hearing loss. MATERIALS AND METHODS70 consenting patients of age 20 -60 yrs. with Non-Syndromic Chronic Kidney Disease referred from Nephrology Department were divided into 2 groups of 35 each, those with hearing loss i.e. HL group and without hearing loss i.e. non-HL group. Their demographic details and duration of the disease were recorded. They were subjected to physical examination, blood investigations and pure tone audiometry. Both groups were studied on the basis of above parameters. RESULTSIn the HL group, most patients (54.3%) were shown to have mild degree of hearing loss and higher frequencies were mostly affected. In addition, there was a comparatively stronger association of hyponatraemia and hypokalaemia with HL group than with non-HL group. Mean duration of the disease and haemodialysis was higher in HL group than in non-HL group. CONCLUSIONThe patients of Chronic Kidney Disease have mild degree of hearing loss, mostly at higher frequencies. A longer duration of the disease and haemodialysis are directly related to the hearing loss. Nonetheless, low serum sodium and potassium has a stronger relation with hearing loss group than in non-hearing loss group.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Acharya¹,

Pati²,

Nayak³

2017

jemds

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“…Gafter et al [12] found that patients with end stage CRF before the initiation of dialysis treatment and patients on long-term dialysis had delayed latencies of waves III and V. Furthermore, the second group had prolonged interpeak latency I-V. Mancini et al [13] reported similar findings; these data indicated that neural conduction along the auditory pathway is delayed irrespectively of hemodialysis onset, basically due to the disease. Gafter et al [12] and Mancini et al [13] reported that there was no correlation between ABR and blood level measures.…”

Section: Introductionmentioning

confidence: 88%

“…Gafter et al [12] and Mancini et al [13] reported that there was no correlation between ABR and blood level measures.…”

Section: Introductionmentioning

confidence: 99%

Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

Aspris

Thodi²,

Balatsouras

et al. 2008

Renal Failure

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This study evaluated the effects of end stage chronic renal failure (CRF) on auditory function and changes in auditory function following a single session of hemodialysis. The experimental group included 31 patients with end-stage renal failure on chronic hemodialysis. The control group consisted of 31 healthy volunteers. The patients were examined prior to and following a session of hemodialysis. Measurements included pure tone audiometry, tympanometry and acoustic reflex measurements, auditory brainstem responses (ABR), and blood now chemistry parameters. Controls underwent the same test battery, with the exception of biochemical and hematological assessment. Prior to hemodialysis sessions, all ABR latencies except interpeak latency I-III were significantly prolonged in the experimental group. A comparison between controls and the experimental group following hemodialysis indicated that wave V absolute latency and interpeak latencies III-V and I-V were significantly prolonged in the slow repetition rate paradigm. In the fast repetition rate, absolute latencies of waves I and V and III-V interpeak latencies were prolonged in the experimental group. Comparison of ABR recordings prior to and following hemodialysis showed overall significant difference between the measures. Post hoc analysis showed a significant improvement in wave I and V latencies in the slow repetition rate and wave V latency in the fast repetition rate. This study showed that neural conduction along the auditory pathway is delayed in patients with end stage CRF as compared to healthy subjects. Dialysis sessions improve overall neural auditory function. However, patients with end stage CRF show delayed conduction even after a session of hemodialysis.

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“…6 Sensorineural hearing impairment prevalence in pediatric transplant group was higher than in the chronic renal failure group (47% against 29%) in Mancini's study, and they found a significant correlation with the administration of ototoxic drugs after transplant (eg, aminoglycosides and furosemide). 7 Sensorineural hearing impairment prevalence was 62% in our patient group, and it was high when compared with the general population of children. Our higher prevalence may be related to the assessment that was performed without symptoms.…”

Section: Decibels Hertzmentioning

confidence: 52%

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Gülleroğlu

Baskın²,

Aydın³

et al. 2015

Exp Clin Transplant

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Objectives: Renal transplant provides a long-term survival. Hearing impairment is a major factor in subjective health status. Status of hearing and the cause of hearing impairment in the pediatric renal transplant group have not been evaluated. Here, we studied to evaluate hearing status in pediatric renal transplant patients and to determine the factors that cause hearing impairment. Materials and Methods: Twenty-seven pediatric renal transplant recipients were investigated. All patients underwent audiologic assessment by means of pure-tone audiometry. The factors on hearing impairment were performed. Results: Sensorineural hearing impairment was found in 17 patients. There was marked hearing impairment for the higher frequencies between 4000 and 8000 Hz. Sudden hearing loss developed in 2 patients, 1 of them had tinnitus. Decrease of speech understanding was found in 8 patients. The cyclosporine level was significantly high in patients with hearing impairment compared with group without hearing impairment. Cyclosporine levels also were found to be statistically significantly high when compared with the group with decrease of speech understanding and the group without decrease of speech understanding. Similar relations cannot be found between tacrolimus levels and hearing impairment and speech understanding. Conclusions: Sensorineural hearing impairment prevalence was high in pediatric renal transplant recipients when compared with the general population of children. Cyclosporine may be responsible for causing hearing impairment after renal transplant. We suggest that this effect is a dose-dependent toxicity.

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Sensorineural hearing loss in patients reaching chronic renal failure in childhood

Cited by 47 publications

References 15 publications

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Auditory Brainstem Responses in Patients under Treatment of Hemodialysis

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