Sensorineural Hearing Loss in Cholesteatoma

Rosito, Letícia S.; Netto, Luciana Silveira; Teixeira, Adriane Ribeiro; Costa, Sady Selaimen da

doi:10.1097/mao.0000000000000952

Cited by 16 publications

(18 citation statements)

References 9 publications

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“…In this study, an LSCC fistula was detected in 12 (7.5%) patients, who had significantly greater BC differences at 4000 Hz. These findings are in line with Rosito et al, 8 who reported 6% of patients with an LSCC fistula, and a significant association between SNHL and the presence of an LSCC fistula. Unlike our findings, Jesic et al 14 reported that they did not find a significant association between presence of an LSCC fistula and SNHL.…”

Section: Discussionsupporting

confidence: 92%

“…1,[7][8][9][10][11][12][13][14][15][16] Some have reported statistically significant SNHL on the side of the COM, compared to intact ears, 1,[7][8][9][10][11][12][13][14] whereas others have not. 15,16 Although some studies have differentiated COM with and without cholesteatoma, 7,[9][10][11][12][13][14][15] few have evaluated SNHL in patients with cholesteatoma, 1,8 and the relationship between SNHL and cholesteatoma is not yet clearly understood. 1,8,14 We assessed whether cholesteatoma is associated with SNHL and investigated the effects of a lateral semicircular canal (LSCC) fistula, destruction of stapes, localization of cholesteatoma, and air-bone gap (ABG) size on SNHL.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Presence of Sensorineural Hearing Loss and the Relationship With Intraoperative Findings in Cholesteatoma

et al. 2019

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We investigated whether cholesteatoma is associated with sensorineural hearing loss (SNHL) and the effects of a lateral semicircular canal (LSCC) fistula, destruction of stapes, localization of cholesteatoma, and air–bone gap (ABG) size on SNHL. The charts of 159 patients who had received surgery for unilateral cholesteatoma were examined retrospectively. In all patients, air conduction and bone conduction (BC) thresholds in both ears were measured at 500, 1000, 2000, and 4000 Hz. Differences in BC thresholds between ears with cholesteatoma and contralateral ears were calculated. Demographics, localization of cholesteatoma, presence of LSCC fistula, condition of stapes, and ABG size on the affected ear were evaluated. There were significantly greater BC thresholds in ears with cholesteatoma than in normal ears for each frequency. Comparing the average BC differences at the different cholesteatoma locations, there were significant differences between the tympanic cavity + all mastoid cell group and attic, attic + antrum, and tympanic cavity + antrum groups. The BC differences at 4000 Hz were significantly high in patients with LSCC fistula. There were no significant relationships between the condition of the stapes and BC differences at any frequencies. There were significant correlations between average ABG and BC threshold differences at all frequencies. A significant relationship was found between cholesteatoma and SNHL. Patients with advanced cholesteatoma had significantly higher levels of SNHL. The BC threshold differences increased with increases in the ABG.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Presence of Sensorineural Hearing Loss and the Relationship With Intraoperative Findings in Cholesteatoma

et al. 2019

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“…Furthermore, when the literature is reviewed, cases with hearing loss were observed in various disease groups, which may also be encountered in patients with cholesteatoma. [24][25][26] The relationship between sclerostin level and hearing loss can also be evaluated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Serum sclerostın levels ın chronıc otıtıs medıa wıth and wıthout cholesteatoma

Karalı

Yis

2020

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE Sclerostin is a glycoprotein that plays a catabolic role in bone and is involved in the regulation of bone metabolism by increasing the osteoclastic bone resorption. In this study, serum sclerostin levels were measured in chronic otitis media (COM) with and without cholesteatoma, assuming that it might have a role in the aetiopathogenesis of bone resorption. METHODS A total of 44 patients with cholesteatomatous COM (cCOM) (n = 22) and non-cholesteatomatous COM (ncCOM) (n = 22) were included in this study, and 26 healthy volunteers without any chronic ear disease problem(s) constituted the control group (n = 26). RESULTS No significant difference was not found in terms of serum iPTH, ALP, and vitamin D levels between ncCOM, cCOM, and the control groups. A significant difference was found in terms of serum sclerostin, Ca, and P levels between ncCOM, cCOM, and the control groups (p<0.05). Serum sclerostin levels in the study groups were significantly higher but their serum Ca and P levels were significantly lower compared to the control group. CONCLUSION We think that serum sclerostin concentrations, which were significantly higher in patients with cCOM and ncCOM compared to healthy controls are associated with bone erosion. There is a need for further studies with larger samples in order to determine the relationship between sclerostin and bone erosion in cholesteatoma to help in establishing preventive measures against cholesteatoma and set new targets for the development of non-surgical treatments.

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“…They have a capacity for bony erosion and neurovascular compromise, potentially resulting in numerous complications including conductive and/or sensorineural hearing loss, vestibular dysfunction, facial paralysis, or even potentially fatal intracranial complications. 1-4 Although cholesteatomas are commonly confined to the middle ear or mastoid air-cells, there are a small number that grow beyond these confines, to extend intracranially or medially to involve the otic capsule, facial nerve at the labyrinthine or geniculate segments, and petrous apex.…”

Section: Introductionmentioning

confidence: 99%

The Medially-Invasive Cholesteatoma: An Aggressive Subtype of a Common Pathology

Casazza

Carlson

Shelton

et al. 2020

Ann Otol Rhinol Laryngol

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Objective: Describe the outcomes of treatment for patients with cholesteatomas that are medially invasive to the otic capsule, petrous apex, and/or skull base. Study Design: Retrospective case series Setting: Two tertiary care academic centers. Patients: Patients surgically managed for medially-invasive cholesteatoma at two tertiary care institutions from 2001 to 2017. Interventions: Surgical management of medially-invasive cholesteatomas. Main Outcome Measures: The presenting symptoms, imaging, pre- and post-operative clinical course, and complications were reviewed. Results: Seven patients were identified. All patients had pre-operative radiographic evidence of invasive cholesteatoma with erosion into the otic capsule beyond just a lateral semicircular canal fistula. Five patients had a complex otologic history with multiple surgeries for recurrent cholesteatoma including three with prior canal wall down mastoidectomy surgeries. Average age at the time of surgery was 41.3 years (range 20-83). Two patients underwent a hearing preservation approach to the skull base while all others underwent a surgical approach based on the extent of the lesion. Facial nerve function was maintained at the pre-operative level in all but one patient. No patient developed cholesteatoma recurrence. Conclusions: The medially-invasive cholesteatoma demonstrates an aggressive, endophytic growth pattern, invading into the otic capsule or through the perilabyrinthine air cells to the petrous apex. Surgical resection remains the best treatment option for medially-invasive cholesteatoma. When CSF leak is a concern, a subtotal petrosectomy with closure of the ear is often necessary.

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Sensorineural Hearing Loss in Cholesteatoma

Abstract: Cholesteatoma was associated with greater BC thresholds at all frequencies tested. The differences were independent of cholesteatoma growth patterns. As bigger the air bone gap in the ear with cholesteatoma, greater the inner ear damage.

Cited by 16 publications

References 9 publications

Evaluation of the Presence of Sensorineural Hearing Loss and the Relationship With Intraoperative Findings in Cholesteatoma

Evaluation of the Presence of Sensorineural Hearing Loss and the Relationship With Intraoperative Findings in Cholesteatoma

Serum sclerostın levels ın chronıc otıtıs medıa wıth and wıthout cholesteatoma

The Medially-Invasive Cholesteatoma: An Aggressive Subtype of a Common Pathology

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