Sensorineural hearing loss and volatile organic compound metabolites in urine

Pudrith, Charles; Dudley, William N.

doi:10.1016/j.amjoto.2019.03.001

Cited by 11 publications

(9 citation statements)

References 28 publications

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“…Some previous studies have demonstrated a relationship between VOCs and HFHL in individuals without a history of noise exposure 14 , 15 . However, these studies did not find a relationship between HFHL and VOCs in individuals with a history of noise exposure.…”

Section: Discussionmentioning

confidence: 95%

“…However, there have been few studies on the relationship between VOCs and hearing thresholds A previous study demonstrated that the co-exposure of VOCs and/or heavy metals with noise exposure may exacerbate the risk of noise-induced hearing loss in occupational workers 13 . Additionally, only a handful of studies have described an association between higher levels of VOCs, in the absence of noise exposure, and high-frequency hearing loss (HFHL) 14 , 15 . Furthermore, one of those studies did not consider middle ear status, which can be affected by VOCs 15 .…”

Section: Introductionmentioning

confidence: 99%

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Higher exposure to 1,3-butadiene is associated with more severe hearing loss

Han,

Lee,

Suh

et al. 2024

Sci Rep

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While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-l-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-l-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-l-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Higher exposure to 1,3-butadiene is associated with more severe hearing loss

Han,

Lee,

Suh

et al. 2024

Sci Rep

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“…So far, some metabolomics studies have been performed in noise exposure eld (Floegel et al 2013, Huang et al 2018, Zhang et al 2016). Pudrith et al (Pudrith &Dudley 2019) found ve metabolites related to glutathione-dependent mercapturic acids in urine, while signi cant associations were just only found in non-noise exposure subjects. Fujita et al (Fujita et al 2015) revealed that ten metabolites exhibited statistically signi cant changes in inner ear uid of guinea pig that exposed to loud noise, including amino acid catabolites and lipid compounds.…”

Section: Discussionmentioning

confidence: 98%

Plasma metabolomic profiling in workers with noise-induced hearing loss: a pilot study

Miao

Wang

Zhang

et al. 2021

Environ Sci Pollut Res

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Noise-induced hearing loss (NIHL) remains a leading occupational related disease and is a serious public health problem. Hence, the identi cation of potential biomarkers for NIHL prevention and diagnosis has become an urgent work. To discover potential metabolic biomarkers of NIHL, plasma metabolomics analysis among 62 NIHL patients and 62 controls was performed using ultrahigh performance liquid chromatography-mass spectrometry (UPLC/MS).Orthogonal partial least square-discriminant analysis (OPLS-DA) model was applied to distinguish metabolite pro le alterations in plasma samples between the two groups. The alterations in autophagy pathway were in accordance with previous published studies, therefore, three autophagy-related genes (PI3K, AKT and ATG5) were selected and mRNA levels were detected by RT-qPCR analysis in peripheral white blood cells (WBCs) samples. Compared to the control group, 20 identi ed plasma metabolites were signi cantly altered in NIHL patients. Meanwhile, a total of seven metabolic pathways were enriched, including glycerophospholipid metabolism, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, autophagy, choline metabolism, alpha-linolenic acid metabolism and linoleic acid metabolism, and retrograde endocannabinoid signaling pathway. Furthermore, the results indicated that the mRNA levels of three autophagy-related genes (PI3K, AKT and ATG5) were signi cantly decreased in NIHL cases compared with controls. Taken together, our current study rstly provides evidence that the identi ed aberrantly altered metabolites might be potential biomarkers of NIHL for noise-exposed workers. In addition, autophagy pathway may be involved in the occurrence and development of NIHL.

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Section: Discussionmentioning

confidence: 98%

Plasma Metabolomic Profiling in Workers With Noise-induced Hearing Loss: A Pilot Study

Miao¹,

Wang²,

Zhang³

et al. 2021

Preprint

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Noise-induced hearing loss (NIHL) remains a leading occupational related disease and is a serious public health problem. Hence, the identification of potential biomarkers for NIHL prevention and diagnosis has become an urgent work. To discover potential metabolic biomarkers of NIHL, plasma metabolomics analysis among 62 NIHL patients and 62 controls was performed using ultrahigh performance liquid chromatography-mass spectrometry (UPLC/MS). Orthogonal partial least square-discriminant analysis (OPLS-DA) model was applied to distinguish metabolite profile alterations in plasma samples between the two groups. The alterations in autophagy pathway were in accordance with previous published studies, therefore, three autophagy-related genes (PI3K, AKT and ATG5) were selected and mRNA levels were detected by RT-qPCR analysis in peripheral white blood cells (WBCs) samples. Compared to the control group, 20 identified plasma metabolites were significantly altered in NIHL patients. Meanwhile, a total of seven metabolic pathways were enriched, including glycerophospholipid metabolism, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, autophagy, choline metabolism, alpha-linolenic acid metabolism and linoleic acid metabolism, and retrograde endocannabinoid signaling pathway. Furthermore, the results indicated that the mRNA levels of three autophagy-related genes (PI3K, AKT and ATG5) were significantly decreased in NIHL cases compared with controls. Taken together, our current study firstly provides evidence that the identified aberrantly altered metabolites might be potential biomarkers of NIHL for noise-exposed workers. In addition, autophagy pathway may be involved in the occurrence and development of NIHL.

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Sensorineural hearing loss and volatile organic compound metabolites in urine

Cited by 11 publications

References 28 publications

Higher exposure to 1,3-butadiene is associated with more severe hearing loss

Higher exposure to 1,3-butadiene is associated with more severe hearing loss

Plasma metabolomic profiling in workers with noise-induced hearing loss: a pilot study

Plasma Metabolomic Profiling in Workers With Noise-induced Hearing Loss: A Pilot Study

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