Sensorineural Hearing Loss

Magalhães, Cristina Medeiros Ribeiro de; Alves, Natália R. Magalhães; Oliveira, Karina Maria Alécio de; Silva, Isabella M.C.; Gandolfi, Lenora; Pratesi, Riccardo

doi:10.1097/rhu.0b013e3181f603bc

Cited by 38 publications

(16 citation statements)

References 21 publications

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“…Several children (n = 41, 13.6%) disclosed neurosensorial hearing loss (NSHL). Our finding is similar to results obtained by other authors [23,24]. In a recent review [23], it was determined that some degree of NSHL affects approximately 36% of all patients with KD, and at least 14% of those children disclosed a persistent NSHL.…”

Section: Discussionsupporting

confidence: 92%

“…We do not have an explanation for this increased rate of recurrence aside from the fact that this was a group of patients closely monitored by the same team during a relatively extended period. Few studies have evaluated neurological complications of Kawasaki disease; most of them are case reports [4,23,24]. These studies describe neurological changes based on an area of cerebral ischemia or involvement of the facial nerve with facial paralysis, cochlear nerve leading to ataxia, and impairment of the acoustic nerve with sensorineural hearing loss [4,23,24].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Magalhães¹,

Almeida²,

Gandolfi³

et al. 2020

Medicina

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Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe and correlate the clinical features of this disorder with the children’s age at the time of disease onset, (3) to correlate the frequent lack of early diagnosis with a delayed application of appropriate treatment, and (4) to describe the outcome and eventual recurrences of KD in our region. Materials and Methods: Three hundred and one participants (183 males and 118 females) included in the study were diagnosed and, subsequently, clinically followed for ten years (January 2007 to December 2016) at the Pediatric Rheumatology Walk-in Clinic of the Children’s Hospital of Brasilia. Results: Episodes ranged from four months to two years. This rate of recurrence was well-above that disclosed by previous reports. Delay in diagnosis, in all age groups, caused an undesirable delay between the disease onset, the final diagnosis, and the administration of intravenous immunoglobulin (IVIG). KD recurred in 25 (8.3%) of the children during the first three years of follow-up. In seven patients, KD recurred twice, with an interval between episodes ranging from four months to two years. Conclusions: This rate of recurrence was well-above that disclosed by previous reports. In Latin America, aside from a handful of physicians and researchers, KD is being ignored. There is a pressing need to educate primary health care physicians and bring awareness to the fact that KD is not an exotic condition that affects only the Asian populations but a disorder that already exists among us and that frequently results in severe consequences.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Magalhães¹,

Almeida²,

Gandolfi³

et al. 2020

Medicina

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“…Nevertheless, the presence of anemia and thrombocytosis, and the increased aspartate aminotransferase/alanine aminotransferase described in Magalhaes et al 8) and Alves et al 10) did not show a significant difference between the groups in this study.…”

Section: Discussioncontrasting

confidence: 64%

“…Patient's hearing was assessed at 48 hours of defervescence after high-dose aspirin intake and at the eighth week of outpatient visit, using pure tone audiometry in patients over three years of age (19 cases) and brainstem-evoked response audiometry in patients less than three years of age or in patients unwilling to cooperate (40 cases) 4 8) . The Clark classification was applied for determining the severity of hearing loss ( Table 1 ) 13) .…”

Section: Methodsmentioning

confidence: 99%

“…In previous studies, various cases of sensorineural hearing loss duration, directionality, and severity have been reported in Kawasaki disease 4 5 6 7 8 9 10 11) . According to Magalhaes et al 8) , and Alves et al 10) , in Kawasaki disease, the patients with permanent sensorineural hearing loss showed anemia and thrombocytosis significantly more often, and had a longer duration of the increase in the erythrocyte sedimentation rate than patients with temporary hearing loss. In the meantime, Knott et al 4) , and Sundel et al 7) suggested that the ototoxicity of the high-dose aspirin that was used for the treatment of the acute phase might cause sensorineural hearing loss.…”

Section: Introductionmentioning

confidence: 98%

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Sensorineural hearing loss in patients with Kawasaki disease

Park

Kim

et al. 2015

Korean J Pediatr

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PurposeKawasaki disease involves acute febrile systemic vasculitis that can cause a variety of symptoms by affecting various organs. Here, we aimed to evaluate the prevalence, causes, and prognosis of sensorineural hearing loss (SNHL) occurring in children with Kawasaki disease.MethodsPatients who were diagnosed with Kawasaki disease and received inpatient treatment in the Pediatrics Department at one of three university hospitals in Daegu city from February 2012 to September 2012 were enrolled in the study. The clinical features, hematological results, echocardiography results, audiometry results, and aspirin and salicylic acid serum levels of the patients were evaluated.ResultsOf the 59 children enrolled in the study, three showed mild bilateral SNHL on audiometry tests conducted after 48 hours of defervescence; these patients demonstrated normal patterns of recovery on follow-up tests 8 weeks later. Aspirin serum levels were significantly higher in the SNHL group after 48 hours of afebrile condition with high dose aspirin intake (P=0.034). However, no significant differences were found in other laboratory tests or for fever duration (P>0.05). Upon echocardiography, coronary artery abnormality was observed in 9 cases, but none of these patients showed hearing loss.ConclusionThe results indicate that SNHL in children with Kawasaki disease might occur during treatment of the acute phase; this SNHL usually involves mild bilateral hearing loss and recovers naturally. However, this study suggests that determination of the causes and clinical implications of hearing loss in Kawasaki disease requires long-term follow-up studies with more cases.

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