Sensorineural dysacusis in patients with systemic lupus erythematosus

Gomides, Ana Paula Monteiro; Rosário, Eduardo José do; Borges, H.M.; Gomides, H.H.M.; Pádua, Paulo Madureira de; Sampaio-Barros, Percival D.

doi:10.1177/0961203307084160

Cited by 33 publications

(25 citation statements)

References 16 publications

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“…This result agrees with those of other studies which found no correlation between hearing threshold and age, organ system involvement, SLE duration or SLE severity. 1,4,12,16,17,20 However, this may be due to the Our study patients were enrolled at a younger age than those of previously reported studies; however, at 10-year follow up our patients' mean age was similar to that of patients reported earlier (Table III). Considering the age of our patients, it would be reasonable to exclude the effect of some inner ear disorders, such as age-related hearing loss (presbycusis) and long-term exposure to environmental noise (e.g.…”

Section: Discussionmentioning

confidence: 49%

“…However, an increased prevalence of subclinical or slowly progressive SNHL has been reported in SLE patients. [16][17][18] Based on their audiometric studies, Roverano et al 4 have recommended that audiometric tests be included as part of initial studies in patients with systemic lupus disease.…”

Section: Discussionmentioning

confidence: 99%

“…Pts = patients; yr = years; SNHL = sensorineural hearing loss; Abs = antibodies; NSAIDS = non-steroidal anti-inflammatory drugs; MTX = methotrexate; NR = not reported; DHEA = dehydroepiandrosterone small number of patients enrolled in our study; therefore, our findings must be interpreted with caution.Cordeschi et al16 observed progressive cochlear impairment in SLE patients.The majority of reports5,13,[15][16][17]21 compared patient hearing assessments with those of age-matched, healthy subjects. However, the present study utilised two types of comparison to assess the hearing of a group of young SLE patients: SLE patients versus healthy control subjects, and initial versus final hearing values after long-term follow up.• Systemic lupus erythematosus (SLE) has been termed a prototype immune complex disease • Sensorineural hearing loss may occur in SLE, and may be its presenting symptom • This 10-year follow-up study found no hearing loss in young SLE patients • Young SLE patients need audiological investigation only for evident hearing loss or other clinical reasons • Other hearing tests are time-consuming and not cost-effective…”

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confidence: 99%

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Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

et al. 2012

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These results supply no evidence for progressive hearing loss in systemic lupus erythematosus patients with no hearing involvement at study commencement. Therefore, we recommend audiometric tests only for systemic lupus erythematosus patients complaining of hearing loss, or for other clinical purposes. It is conceivable that asymptomatic hearing loss could be observed over a more extended follow-up period (i.e. more than 10 years).

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

et al. 2012

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“…41 Subclinical SNhl in rheumatic diseases an increased prevalence of subclinical or slowly progres sive snHl has been reported in patients with ra, sjögren's syndrome, sle, wG and systemic sclero sis. 27,42,43 no correlation has been observed with disease activity. the disease mechanism and implications for therapy outside of acute or rapidly progressive symptoms are uncertain.…”

Section: Snhl In Other Clinical Contextsmentioning

confidence: 98%

Idiopathic sensorineural hearing disorders in adults—a pragmatic approach

George

Pradhan

2009

Nat Rev Rheumatol

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Acute or progressive sensorineural hearing loss, with or without vertigo and tinnitus, has a considerable impact upon an individual's quality of life. Sensorineural hearing disorders are more commonly observed in patients with rheumatic disease than in the general population, are more likely to be accompanied by the presence of serum autoantibodies, and might respond to steroid therapy. A subgroup of these disorders seem to be immune mediated, but audiologic presentation and serologic testing do not enable this subgroup to be further defined. Rheumatologists should be prepared to manage patients with known rheumatic disease who develop acute hearing loss and to evaluate referred patients without known rheumatic illness experiencing progressive or refractory sensorineural hearing loss. In this article, we summarize the literature and outline a rational approach for the evaluation and treatment of such patients.

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“…Apabila vaskulitis terdapat pada arteri labirin dan cabangnya pada penderita LES, keadaan tersebut mengakibatkan gangguan pada pendengaran. [3][4][5] Kerusakan telinga pada pasien LES sudah banyak dilaporkan. Pada penelitian di Polandia pada tahun 2009 terhadap 35 pasien LES, dari pemeriksaan brainstem evoked respons auditory (BERA) didapatkan bahwa 10 orang mengalami gangguan dengar sensorineural secara simetris pada frekuensi tinggi.…”

Section: Pendahuluanunclassified

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

Wijana¹,

Mutiara²,

Agustian³

2016

mkb

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AbstrakLupus eritematosus sistemik (LES) merupakan penyakit kronik mengenai multisistem, merupakan gangguan autoimun yang ditandai oleh produksi autoantibodi dan deposisi kompleks imun di jaringan. Manifestasi klinis dapat meliputi berbagai organ termasuk telinga. Pada telinga dapat menimbulkan gangguan dengar, tinitus, dan vertigo. Gangguan dengar terjadi bilateral pada frekuensi tinggi. Prednison merupakan kortikosteroid oral yang memiliki efek glukokortikoid yang bersifat anti-inflamasi dan imunosupresif. Penelitian ini bertujuan mengetahui pengaruh prednison terhadap perbaikan pendengaran penderita LES. Penelitian dilakukan periode Maret-Mei 2013 di Poliklinik Gangguan Dengar dan Bicara, Telinga Hidung Tenggorok Bedah Kepala dan Leher Rumah Sakit Dr. Hasan Sadikin Bandung menggunakan metode quasi-experimental dengan rancangan one group pretestposttest design dan hasilnya dihitung secara statistik menggunakan uji Rank Spearman. Pada 28 subjek pasien LES dilakukan anamnesis, pemeriksaan fisis, laboratorium, audiometri nada murni, timpanometri, dan distortion production otoacoustic emissions. Subjek diberi prednison 1 mg/kgBB/hari (dosis maksimal 60 mg/hari) selama 4 minggu, kemudian dilakukan evaluasi ulang. Sebelum terapi, 26 subjek mengalami gangguan dengar sedang pada frekuensi tinggi, simetris. Sesudah terapi, 24 subjek ambang dengar menjadi normal dan 4 subjek tetap mengalami gangguan dengar (Rs=0,734; p<0,01 Prednisone Effect to on Hearing Status of Systemic Lupus Erythematosus Patients AbstractSystemic lupus erythematosus (SLE) is a chronic, multi-system, autoimmune disorder characterized by the production of autoantibodies and immune complexes deposition in tissue. Clinical manifestations may include skin, mucosa, joints, blood, heart, lungs, kidneys, central nervous system (CNS), immune system, and ears. SLE Iin the ears can caused sensorineural hearing loss, tinnitus, and vertigo. This hearing disorder is commonly bilateral and has high frequencies. Prednisone is an oral corticosteroid with glucocorticoid and mineralocorticoid effects. Glucocorticoids have anti-inflammatory and immunosuppressive effects. The aim of this study was to evaluate the effect of prednisone in improving the degree of hearing loss in patients with SLE. This study was conducted in from March-May 2013, at tThe Hearing and Speech Disorder Clinic of Ear Nose Throat-Head and Neck Surgery, Dr. Hasan Sadikin Hospital Bandung, using quasi-experimental method with pre-post design in which the results were statistically calculated using Rank Spearman test. This study involved 28 subjects who had been diagnosed for SLE. Anamnesis, physical examination, and laboratory test were performed, followed by pure tone audiometry, tympanometry, and distortion product optoacoustic emissions (DPOAE). Subjects were given prednisone 1 mg/kgBW/day with a maximum dose of 6o mg/day. Re-evaluation was performed after 4 weeksof treatment. Before treatment, 26 subjects had mild hearing loss and 2 subjects had symmetric moderate hearing loss at high freque...

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Sensorineural dysacusis in patients with systemic lupus erythematosus

Cited by 33 publications

References 16 publications

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

Idiopathic sensorineural hearing disorders in adults—a pragmatic approach

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

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