Sensorineural and vascular changes in an ear with acoustic neurinoma

Johnsson, Lars‐Göran; Hawkins, Joseph E.; Rouse, Roland C.

doi:10.1016/s0196-0709(84)80020-4

Cited by 18 publications

(6 citation statements)

References 22 publications

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“…The exact cause of the diminished signal intensity is not well understood. Previous studies indicate that the presence of a VS causes significant biochemical alterations of the inner ear fluids (31Y33), with an increased perilymphatic protein content (33,34). It has been suggested that these alterations are related to vascular impairment caused by mechanical obstruction by the VS (30,31).…”

Section: Predictors Of Change In Audiologic Functionmentioning

confidence: 99%

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Langenberg¹,

Bondt²,

Nelemans³

et al. 2011

Otology &Amp; Neurotology

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Hypointensity on T2-weighted image of the affected labyrinth will result in a significant faster deterioration of hearing. Hearing loss was more profound, and hearing will deteriorate significantly faster in patients presenting with complaints of hearing loss. Significant growth during the first year of FU predicts further growth during FU. Sequential MRI cannot be substituted by audiologic examinations solely because increase in VS volume does not correlate with audiologic deterioration significantly.

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Section: Predictors Of Change In Audiologic Functionmentioning

confidence: 99%

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Langenberg¹,

Bondt²,

Nelemans³

et al. 2011

Otology &Amp; Neurotology

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“…In theory, the hearing loss may occur as a result of dysfunction of the cochlear nerve (a retrocochlear mechanism), or due to dysfunction of the cochlea (a cochlear mechanism), or both mechanisms may occur in a given case. Clinicians commonly think of VS-associated hearing loss as occurring due to dysfunction of the cochlear nerve; supporting evidence includes retrocochlear abnormalities on auditory brainstem response measurements (4,5) and histopathologic data demonstrating atrophy of the cochlear nerve (6,7). Less attention has focused on dysfunction of the cochlea caused by VS as a factor that contributes to the hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Dysfunction of the Cochlea Contributing to Hearing Loss in Acoustic Neuromas

Röösli¹,

Linthicum²,

Cüreoğlu³

et al. 2012

Otology &Amp; Neurotology

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Objective Hearing loss is a common symptom in patients with cochleovestibular schwannoma (VS). Clinical and histological observations have suggested that the hearing loss may be caused by both retrocochlear and cochlear mechanisms. Our goal was to perform a detailed assessment of cochlear pathology in patients with VS. Study Design Retrospective analysis of temporal bone histopathology. Setting Multi-center study. Material Temporal bones from 32 patients with unilateral, sporadic VS within the internal auditory canal. Main Outcome Measures Sections through the cochleae on the VS side and opposite (control) ear were evaluated for loss of inner and outer hair cells, atrophy of the stria vascularis, loss of cochlear neurons, and for presence of endolymphatic hydrops and precipitate within endolymph or perilymph. Observed pathologies were correlated to nerve of origin, VS volume, and distance of VS from the cochlea. Hearing thresholds were also assessed. Results VS caused significantly more inner and outer hair cell loss, cochlear neuronal loss, precipitate in endolymph and perilymph, and decreased pure tone average, when compared to the opposite ear. Tumor size, distance from the cochlea, and nerve of origin did not correlate with structural changes in the cochlea or the hearing threshold. Conclusions There is significant degeneration of cochlear structures in ears with VS. Cochlear dysfunction may be an important contributor to the hearing loss caused by VS, and can explain certain clinically observed phenomena in patients with VS.

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“…The widely accepted view assumes dysfunction of or damage to the eighth cranial nerve or its peripheral branches. This hypothesis is supported by the pathological findings in auditory brainstem response and the cochlear nerve atrophy [15][16][17][18]. Nevertheless, pathological otoacoustic emissions and histopathological abnormalities such as a degeneration of the stria vascularis and the organ of Corti suggest that VS might also account for the cochlear changes [19][20][21].…”

Section: Introductionmentioning

confidence: 87%

Hearing Rehabilitation with Cochlear Implants after CyberKnife Radiosurgery of Vestibular Schwannoma: A Report Based on Four Clinical Cases

et al. 2021

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Severe sensorineural hearing loss can be a symptom of the benign tumor vestibular schwannoma (VS). The treatment of VS with non-invasive stereotactic radiosurgery (SRS) offers a high local tumor control rate and an innovative possibility of sequential hearing rehabilitation with cochlear implantation. This study evaluated the feasibility, complications, and auditory outcomes of such a therapeutic approach. Three males and one female (mean age 65.3 ± 9.4 years) scheduled for cochlear implantation and diagnosed with sporadic VS classified as T1 or T2 (according to Samii) were enrolled in this study. All patients had progressive hearing loss qualifying them for cochlear implantation. First, the tumor was treated using CyberKnife SRS. Next, sequential auditory rehabilitation with a cochlear implant (CI) was performed. Clinical outcomes and surgical feasibility were analyzed, and audiological results were evaluated using pure tone audiometry and speech recognition tests. All patients exhibited open-set speech understanding. The mean word recognition score (at 65 dB SPL, Freiburg Monosyllabic Test, FMT) improved after cochlear implantation in all four patients from 5.0 ± 10% (with hearing aid) preoperatively to 60.0 ± 22.7% six months postoperatively. Our results suggest that in patients with profound hearing loss caused by sporadic vestibular schwannoma, the tumor removal with SRS followed by cochlear implantation is an effective method of auditory rehabilitation.

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Sensorineural and vascular changes in an ear with acoustic neurinoma

Cited by 18 publications

References 22 publications

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Dysfunction of the Cochlea Contributing to Hearing Loss in Acoustic Neuromas

Hearing Rehabilitation with Cochlear Implants after CyberKnife Radiosurgery of Vestibular Schwannoma: A Report Based on Four Clinical Cases

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