Sensorimotor unit activity related to intention in the Pulvinar of behaving Cebus Apella monkeys

Acuña, Carlos; González, Francisco; Domı́nguez, Raquel

doi:10.1007/bf00238034

Cited by 51 publications

(30 citation statements)

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“…Area LIP neurons project to the lateral pulvinar nucleus of the thalamus (Asanuma et al 1985). Neurons in the lateral pulvinar respond to reach movements and combined look-reach movements (Acuña et al 1983) and, in turn, project to parietal area 5 and the medial bank of the intraparietal sulcus, also known as PE and PEa, respectively (Acuña et al 1990; Cappe et al 2007). Reversible inactivation of the lateral pulvinar results in deficits of visually guided reaching without the presence of a visual field defect or primary motor deficit, further suggesting a potential role for the lateral pulvinar in coordinated visual behavior (Wilke et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Spike-field activity in parietal area LIP during coordinated reach and saccade movements

Hagan

Dean

Pesaran

2012

Journal of Neurophysiology

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The posterior parietal cortex is situated between visual and motor areas and supports coordinated visually guided behavior. Area LIP in the intraparietal sulcus contains representations of visual space and has been extensively studied in the context of saccades. However, area LIP has not been studied during coordinated movements, so it is not known whether saccadic representations in area LIP are influenced by coordinated behavior. Here, we studied spiking and local field potential (LFP) activity in area LIP while subjects performed coordinated reaches and saccades or saccades alone to remembered target locations to test whether activity in area LIP is influenced by the presence of a coordinated reach. We find that coordination significantly changes the activity of individual neurons in area LIP, increasing or decreasing the firing rate when a reach is made with a saccade compared with when a saccade is made alone. Analyzing spike-field coherence demonstrates that area LIP neurons whose firing rate is suppressed during the coordinated task have activity temporally correlated with nearby LFP activity, which reflects the synaptic activity of populations of neurons. Area LIP neurons whose firing rate increases during the coordinated task do not show significant spike-field coherence. Furthermore, LFP power in area LIP is suppressed and does not increase when a coordinated reach is made with a saccade. These results demonstrate that area LIP neurons display different responses to coordinated reach and saccade movements, and that different spike rate responses are associated with different patterns of correlated activity. The population of neurons whose firing rate is suppressed is coherently active with local populations of LIP neurons. Overall, these results suggest that area LIP plays a role in coordinating visually guided actions through suppression of coherent patterns of saccade-related activity.

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Section: Discussionmentioning

confidence: 99%

Spike-field activity in parietal area LIP during coordinated reach and saccade movements

Hagan

Dean

Pesaran

2012

Journal of Neurophysiology

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“…Acuna et al, 1983;Perryman et al, 1980;Petersen et al, 1985;Robinson & McClurkin, 1989;Robinson et al, 1986Robinson et al, , 1990Robinson et al, , 1991. In the dorsal lateral pulvinar presaccadic responses are thought to represent an enhancement of the visual response due to the use of the visual stimulus as a saccade target, while postsaccadic responses are thought to be entirely due to the eye movement (Robinson & McClurkin, 1989).…”

Section: Perisaccadic Propertiesmentioning

confidence: 98%

Single neurons with both form/color differential responses and saccade-related responses in the nonretinotopic pulvinar of the behaving macaque monkey

Benevento

Port

1995

Vis Neurosci

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The nonretinotopic portion of the macaque pulvinar complex is interconnected with the occipitoparietal and occipitotemporal transcortical visual systems where information about the location and motion of a visual object or its form and color are modulated by eye movements and attention. We recorded from single cells in and about the border of the dorsal portion of the lateral pulvinar and the adjacent medial pulvinar of awake behaving Macaca mulatto in order to determine how the properties of these two functionally dichotomous cortical systems were represented. We found a class of pulvinar neurons that responded differentially to ten different patterns or broadband wavelengths (colors). Thirty-four percent of cells tested responded to the presentation of at least one of the pattern or color stimuli. These cells often discharged to several of the patterns or colors, but responded best to only one or two of them, and 86% were found to have statistically significant pattern and/or color preferences. Pattern/color preferential cells had an average latency of 79.1 ± 46.0 ms (range 31-186 ms), responding well before most inferotemporal cortical cell responses. Visually guided and memory-guided saccade tasks showed that 58% of pattern/color preferential cells also had saccade-related properties, e.g. directional presaccadic and postsaccadic discharges, and inhibition of activity during the saccade. In the pulvinar, the mean presaccadic response latency was earlier, and the mean postsaccadic response latency was later, than those reported for parietal cortex. We also discovered that the strength of response to patterns or colors changed depending upon the behavioral setting. In comparison to trials in which the monkey fixated dead ahead during passive presentations of pattern and color stimuli, 92% of the cells showed attenuated responses to the same passive presentation of patterns and colors during fixation when these trials were interleaved with trials which also required active saccades to pattern and color targets in the periphery. We conclude that properties which represent the functionally dichotomous object and spatial visual systems are found together in single pulvinar neurons and that the responses of these cells to pattern or color stimuli are influenced by the focus of spatial attention. The pulvinar is the first structure in the brain shown to have neurons which integrate both object and spatial properties and the response latencies indicate that this information is processed before that in cortex. These results are discussed in terms of role of the pulvinar in visual attention as well as its unique role in providing both object feature and spatial location information to the inferotemporal cortex.

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“…The cortical targets of the PM include the inferior parietal lobe, the superior temporal gyrus, the cortex of the superior temporal sulcus, as well as the temporal pole (Baleydier and Mauguiere, 1977;Mauguiere and Baleydier, 1978;Asanuma et al, 1985;Markowitsch et al, 1985;Moran et al, 1987;Yeterian and Pandya, 1989;Schmahmann and Pandya, 1990;Baleydier and Morel, 1992;Hardy and Lynch, 1992;Webster et al, 1993). These thalamocortical projections imply a role for the PM as a visuospatial, somatosensory, or auditory relay (Acuna et al, 1983(Acuna et al, , 1990Cudeiro et al, 1989;Robinson et al, 1991;Robinson and Peterson, 1992;Benevento and Port, 1995).…”

mentioning

confidence: 95%

“…In man, it is the medial subdivision of the pulvinar complex which appears to have undergone the greatest expansion (Browne and Simmons, 1984). While anatomical and physiological studies have designated a role in visual processing for the lateral and inferior subdivisions of the pulvinar (Acuna et al, 1983(Acuna et al, , 1990Blum, 1985;Petersen et al, 1987;Cudeiro et al, 1989;Robinson, et al, 1991;Robinson and Petersen, 1992;Cusick et al, 1993;Gutierrez et al, 1995), the function of the medial subdivision, PM, is less clear. Recent PET and MRI studies have postulated a role for the PM in ''directed attention '' (Anderson, 1987;LaBerge and Buchsbaum, 1990;Mesulam, 1990;Morecraft et al, 1993).…”

mentioning

confidence: 98%

“…Physiological studies have demonstrated that neurons in the PM have visual, auditory, somatosensory, and oculomotor responses (Acuna et al, 1983(Acuna et al, , 1990Yirmiya and Hocherman, 1987;Cudeiro et al, 1989;Robinson et al, 1991;Benevento and Port, 1995). As to its connections, the PM receives its greatest subcortical input from the deep (nonretinal) layers of the superior colliculus, with minor input from the superficial layers of the superior colliculus and brainstem nuclei which include the nucleus of the optic tract and the lateral terminal nucleus (Benevento and Fallon, 1975;Harting et al, 1980;Benevento and Standage, 1983).…”

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confidence: 98%

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Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

et al. 1997

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The medial nucleus of the pulvinar complex (PM) has widespread connections with association cortex. We investigated the connections of the PM with the prefrontal cortex (PFC) in macaque monkeys, with tracers placed into the PM and the PFC, respectively. Injections of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) placed into the PM resulted in widespread anterograde terminal labeling in layers III and IV, and retrograde cellular labeling in layer VI of the PFC. Injections of tracers centered on the central/lateral PM resulted in labeling of dorsolateral and orbital regions, whereas injections centered on caudal, medial PM resulted in labeling of dorsomedial and medial PFC. Since injections of the PM included neighboring thalamic nuclei, retrograde tracers were placed into distinct cytoarchitectonic regions of the PFC and retrogradely labeled cells in the posterior thalamus were charted. The results of this series of tracer injections confirmed the results of thalamic injections. Injections placed into areas 8a, 12 (lateral and orbital), 45, 46 and 11, retrogradely labeled neurons in the central/lateral PM, while tracer injections placed into areas 9, 12 (lateral), 10 and 24, labeled medial PM. The connections of the PM with temporal, parietal, insular, and cingulate cortices were also examined. The central/lateral PM has reciprocal connections with posterior parietal areas 7a, 7ip, and 7b, insular cortex, caudal superior temporal sulcus (STS), caudal superior temporal gyrus (STG), and posterior cingulate, whereas medial PM is connected mainly with the anterior STS and STG, as well as the cingulate cortex and the amygdala. These connectional studies suggest that the central/ lateral and medial PM have divergent connections which may be the substrate for distinct functional circuits.

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Sensorimotor unit activity related to intention in the Pulvinar of behaving Cebus Apella monkeys

Cited by 51 publications

References 54 publications

Spike-field activity in parietal area LIP during coordinated reach and saccade movements

Spike-field activity in parietal area LIP during coordinated reach and saccade movements

Single neurons with both form/color differential responses and saccade-related responses in the nonretinotopic pulvinar of the behaving macaque monkey

Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey

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