Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: A functional MRI study

Opavský, Robert; Hluštı́k, Petr; Otruba, Pavel; Kaňovský, Petr

doi:10.1016/j.jns.2011.03.040

Cited by 53 publications

(62 citation statements)

References 33 publications

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“…This blockade leads to a reduction of Ia afferent signals and indirectly inhibits pre-existing feedback-driven execution mode [38]. This might be the mechanism how BoNT-A treatment reduces maladaptive plasticity; and the hypothesis of central reorganization following BoNT-A treatment is widely supported by the studies employing neurophysiologic and imaging methods in focal and segmental dystonia [13][14][15][16][17] and our own pilot data from patients with post-stroke arm spasticity [21,22].…”

Section: Discussionmentioning

confidence: 98%

“…There is small but growing evidence that BoNT-A also exerts effects through supraspinal mechanisms and can even affect cortical reorganization [12]. The hypothesis of central reorganization following BoNT-A treatment has been supported by studies using neurophysiological and imaging methods in patients with focal dystonia [13][14][15][16][17]. Most of previous fMRI studies in stroke patients have described changes in task-related cortical activity following physiotherapy treatment, e.g., constraint-induced therapy [18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Veverka

Hluštı́k

Tomášová

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Veverka

Hluštı́k

Tomášová

et al. 2012

Journal of the Neurological Sciences

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“…Second, the fact that the majority of patients were treated with botulinum toxin may have influenced our results. Although patients were seen at the end of their efficacy interval (with a mean interval of 4.27 months after the last injection), botulinum toxin has been shown to induce remote central effects, which could possibly have impacted the processing of agency [37]. …”

Section: Discussionmentioning

confidence: 99%

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

et al. 2016

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BackgroundAbnormalities in the cognitive processing of movement have been demonstrated in patients with dystonia. The sense of agency, which is the experience of initiating and controlling one’s own actions, has never before been studied in these patients.ObjectivesWe investigated whether the sense of agency is altered in patients with cervical dystonia.MethodsWe used an explicit metacognitive agency task in which participants had to catch targets with a cursor by moving a computer’s mouse. The task included several conditions in which the control over the cursor could be disrupted by adding a spatial or a temporal discrepancy between the mouse and the cursor’s movements. Participants had to acknowledge these discrepancies and reflect them in metacognitive judgements of agency.ResultsTwenty cervical dystonia patients and 20 matched controls were included in the study. Despite performing equally well as the matched controls, cervical dystonia patients did not fully recognize alterations of agency when a temporal lag was added between their movement and the visual feedback. Moreover, they relied predominantly on their perceived performance to provide judgements of agency and less on their objective degree of controls. There was no correlation between agency scores and clinical severity of dystonia measured by the Toronto Western Spasmodic Torticollis Rating Scale.ConclusionWe demonstrated an abnormal processing of agency in cervical dystonia patients, even for motor actions not affected by dystonia. The exact contribution of abnormal agency to dystonia pathophysiology remains to be clarified.

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“…We also normalized their scans according to the direction of spontaneous rotation by flipping the images in the sagittal plane and reanalyzed regional brain activations. This flipping approach has been previously used by others (29, 30, 39). Within- and between-group analyses were repeated after the data were flipped to test if the dominant direction of head movement had any effects.…”

Section: Methodsmentioning

confidence: 99%

A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia

et al. 2016

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Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

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Sensorimotor network in cervical dystonia and the effect of botulinum toxin treatment: A functional MRI study

Cited by 53 publications

References 33 publications

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Explicit Agency in Patients with Cervical Dystonia: Altered Recognition of Temporal Discrepancies between Motor Actions and Their Feedback

A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia

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