Sensorimotor gating in manic and mixed episode bipolar disorder

Carroll, Christine A.; Vohs, Jenifer L.; O’Donnell, Brian F.; Shekhar, Anantha; Hetrick, William P.

doi:10.1111/j.1399-5618.2007.00415.x

Cited by 32 publications

(35 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…GSK-3β-OX mice are also hyperactive with impaired habituation to a novel environment and reduced depression related behavior (Prickaerts et al, 2006). These mice also have an increased startle response, which is in contrast to reports of low startle response, in acutely manic (Perry et al, 2001), mixed episode (Carroll et al, 2007), and remitted bipolar patients (Giakoumaki et al, 2010). …”

Section: Genetic Models Of Bipolar Maniacontrasting

confidence: 69%

Animal models of bipolar mania: The past, present and future

2016

View full text Add to dashboard Cite

Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the World Health Organization and affects nearly 6 million (~2.5% of the population) adults in the United State alone each year. BD is primarily characterized by mood cycling of depressive (e.g., helplessness, reduced energy and activity, and anhedonia) and manic (e.g., increased energy and hyperactivity, reduced need for sleep, impulsivity, reduced anxiety and depression), episodes. The following review describes several animal models of bipolar mania with a focus on more recent findings using genetically modified mice, including several with the potential of investigating the mechanisms underlying ‘mood’ cycling (or behavioral switching in rodents). We discuss whether each of these models satisfy criteria of validity (i.e., face, predictive, and construct), while highlighting their strengths and limitations. Animal models are helping to address critical questions related to pathophysiology of bipolar mania, in an effort to more clearly define necessary targets of first-line medications, lithium and valproic acid, and to discover novel mechanisms with the hope of developing more effective therapeutics. Future studies will leverage new technologies and strategies for integrating animal and human data to reveal important insights into the etiology, pathophysiology, and treatment of BD.

show abstract

Section: Genetic Models Of Bipolar Maniacontrasting

confidence: 69%

Animal models of bipolar mania: The past, present and future

2016

View full text Add to dashboard Cite

show abstract

“…In particular, it is apparent that rl/+ mice show deficits in LI (present data) and in pre-pulse inhibition (Tueting et al 1999;Swerdlow et al 2006) as did schizophrenic patients (Moser et al 2000), but perform normally in tasks estimating executive functions (Brigman et al 2006) despite such functions (e.g., working memory) are altered in these same patients. Thus, the behavioral phenotype of rl/− mice matches only partially the schizophrenia hallmarks thereby suggesting that rl+/− mice overall provide a valid model for abnormal sensorimotor gating and attention, that is, for symptoms which are not specific to schizophrenia but characterize other pathologies including autism (Keller and Persico 2003;Rubenstein and Merzenich 2003;Perry et al 2007) or bipolar disorders (Carroll et al 2007). …”

Section: Discussionmentioning

confidence: 93%

Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Swerdlow and Koob, 1987). However, it is also critical to note that PPI (and presumably its underlying neural regulation) appears to remain relatively intact, or at least functional, in a number of other serious brain disorders, including attention deficit disorder (ADHD; Castellanos et al, 1996; Conzelmann et al, 2010; Feifel et al, 2009; Hanlon et al, 2012; Ornitz et al, 1992, 1999), high functioning autism (Kohl et al 2014), bipolar disorder (in euthymic states; Barrett et al, 2005; Carroll et al, 2007; but see Sanchez-Morla et al, 2016), and major depressive disorder (Ludewig and Ludewig, 2003; Perry et al, 2004; Quednow et al, 2006), while evidence from chronic substance use disorders is mixed and likely to be substance specific (e.g. Quednow et al, 2004; Schellekens et al, 2012).…”

Section: Theme 1: Ppi Is Impaired Across Categorically Distinct Neuromentioning

confidence: 99%

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

2016

View full text Add to dashboard Cite

Our 1992 paper, ‘The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications’, reviewed a series of (then) new and preliminary findings from cross-species studies of prepulse inhibition of the startle reflex, and commented on their implications. At the time that the report was composed, PubMed listed about 40 citations for studies using the search term ‘prepulse inhibition’. In the ensuing 25 years, the field has added about 2700 such reports, reflecting the substantial growth in interest in prepulse inhibition and its utility across a number of different experimental applications. The 30th anniversary of the Journal of Psychopharmacology provides an opportunity to comment briefly on what was described in that 1992 report, how the field has progressed in the subsequent decades, and the paths forward for studies of prepulse inhibition and its use as an operational measure of sensorimotor gating. Among these future paths, we highlight the use of prepulse inhibition as: an endophenotype for genomic studies, and a biomarker for healthy brain circuitry, which may predict sensitivity to psychotherapeutics. Our 1992 report was highly speculative and based on paper-thin empirical data, yet viewed in a certain light, it appears to have contained a basic roadmap for a journey spanning the next 25 years of prepulse inhibition research… and ‘what a long, strange trip it’s been’.

show abstract

Sensorimotor gating in manic and mixed episode bipolar disorder

Cited by 32 publications

References 30 publications

Animal models of bipolar mania: The past, present and future

Animal models of bipolar mania: The past, present and future

Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

Contact Info

Product

Resources

About