Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort

Hu, Eric; Casamento‐Moran, Agostina; Galaro, Joseph K; Chan, Kimberly L.; Edden, Richard A.E.; Puts, Nicolaas A.J.; Chib, Vikram S.

doi:10.1523/jneurosci.2255-21.2022

Cited by 3 publications

(4 citation statements)

References 49 publications

(78 reference statements)

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“…Alterations in sensorimotor function have been linked physiological fatigue after 40 min on a bicycle ergometer (Hu et al, 2022) and effort-perception (Zenon, Sidibe, & Olivier, 2015). Specifically, current neurobiological accounts state that fatigue and high effort perception arise when sensory consequences of actions (processed in sensorimotor regions) do not match the proprioceptive prediction (i.e.…”

Section: Discussionmentioning

confidence: 99%

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy

van der Schaaf,

Geerligs,

Toni

et al. 2024

Psychol. Med.

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Background Fatigue is a central feature of myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), but many ME/CFS patients also report comorbid pain symptoms. It remains unclear whether these symptoms are related to similar or dissociable brain networks. This study used resting-state fMRI to disentangle networks associated with fatigue and pain symptoms in ME/CFS patients, and to link changes in those networks to clinical improvements following cognitive behavioral therapy (CBT). Methods Relationships between pain and fatigue symptoms and cortico-cortical connectivity were assessed within ME/CFS patients at baseline (N = 72) and after CBT (N = 33) and waiting list (WL, N = 18) and compared to healthy controls (HC, N = 29). The analyses focused on four networks previously associated with pain and/or fatigue, i.e. the fronto-parietal network (FPN), premotor network (PMN), somatomotor network (SMN), and default mode network (DMN). Results At baseline, variation in pain and fatigue symptoms related to partially dissociable brain networks. Fatigue was associated with higher SMN-PMN connectivity and lower SMN-DMN connectivity. Pain was associated with lower PMN-DMN connectivity. CBT improved SMN-DMN connectivity, compared to WL. Larger clinical improvements were associated with larger increases in frontal SMN-DMN connectivity. No CBT effects were observed for PMN-DMN or SMN-PMN connectivity. Conclusions These results provide insight into the dissociable neural mechanisms underlying fatigue and pain symptoms in ME/CFS and how they are affected by CBT in successfully treated patients. Further investigation of how and in whom behavioral and biomedical treatments affect these networks is warranted to improve and individualize existing or new treatments for ME/CFS.

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Section: Discussionmentioning

confidence: 99%

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy

van der Schaaf,

Geerligs,

Toni

et al. 2024

Psychol. Med.

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“…Recent studies have shown that neurotransmitters such as gamma-aminobutyric acid (GABA) and glutamate play a key role in judgments of physical effort and are related to cognitively fatiguing exertion 27,28 . For physical effort, GABA inhibition has been related to changes in descending motor drive and variability in motor output, neural and behavioral signatures that impact feelings of exertion 27 . However, the neurochemical underpinnings of cognitive effort are less straightforward.…”

Section: Discussionmentioning

confidence: 99%

The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Steward,

Chib

2024

Preprint

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Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic resonance imaging to examine brain activity while participants make choices to exert effort for reward, before and after bouts of fatiguing cognitive exertion. We found that when participants became cognitively fatigued, they were more likely to choose to forgo higher levels of reward that required more effort. We describe a mechanism by which signals related to cognitive exertion in dlPFC influence effort value computations, instantiated by the insula, thereby influencing an individual’s decisions to exert while fatigued. Our results suggest that cognitive fatigue plays a critical role in decisions to exert effort and provides a mechanistic link through which information about cognitive state shapes effort-based choice.

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“…Uncertainty arising from this variability may affect the judgment of task performance, leading to inflations in assessment. We have recently showed, in healthy participants, that increased variability serves as an added cost that inflates assessments and valuation of effort 13 .…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesized that variability in participants’ exertion would disrupt their assessments of effort, and dopamine would decrease both exertion variability and the extent to which variability inflates effort assessments. This hypothesis is motivated by studies showing that increased variability in motor output is associated with increased effort costs 6 , 12 , 13 . During effort assessments, such exertion variability may increase uncertainty in performance outcomes, and disrupt accurate effort assessment.…”

Section: Introductionmentioning

confidence: 99%

Dopamine facilitates the translation of physical exertion into assessments of effort

Padmanabhan¹,

Casamento‐Moran

Kim

et al. 2023

npj Parkinsons Dis.

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Our assessments of effort are critically shaped by experiences of exertion. However, it is unclear how the nervous system transforms physical exertion into assessments of effort. Availability of the neuromodulator dopamine influences features of motor performance and effort-based decision-making. To test dopamine’s role in the translation of effortful exertion into assessments of effort, we had participants with Parkinson’s disease, in dopamine depleted (OFF dopaminergic medication) and elevated (ON dopaminergic medication) states, exert levels of physical exertion and retrospectively assess how much effort they exerted. In a dopamine-depleted state, participants exhibited increased exertion variability and over-reported their levels of exertion, compared to the dopamine-supplemented state. Increased exertion variability was associated with less accurate effort assessment and dopamine had a protective influence on this effect, reducing the extent to which exertion variability corrupted assessments of effort. Our findings provide an account of dopamine’s role in the translation of features of motor performance into judgments of effort, and a potential therapeutic target for the increased sense of effort observed across a range of neurologic and psychiatric conditions.

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Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort

Cited by 3 publications

References 49 publications

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy

Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy

The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Dopamine facilitates the translation of physical exertion into assessments of effort

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