Sensor Array Composed of “Clicked” Individual Microcantilever Chips

Paoloni, Francois; Kelling, S.; Huang, Jingwen; Elliott, S. R.

doi:10.1002/adfm.201000729

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…This significantly reduces the synthetic effort required to obtain a large library of chemically fictionalized sensor surfaces. Testing the affinity of these surface coatings towards different solvent vapours using the PSIM readout system, we found that a sensor array composed of four individual MC chips presenting different terminal groups can unambiguously discriminate between a nerve-gas simulant and other solvent vapours (Paoloni et al 2011).…”

Section: Methods: Phase-shifting Interferometric Microscopymentioning

confidence: 99%

Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays

Kelling

Huang²,

Capener³

et al. 2011

J. Breath Res.

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Microcantilever (MC) sensors can provide ultrasensitive bio-chemical detection. Monitoring the bending response of large arrays of MC sensors coated with a library of receptors will produce a characteristic 'breath-print' corresponding to the breath composition; this promises to be suitable for non-invasive medical diagnostics. While MC arrays with hundreds of individual sensors can be produced readily, conventional MC readout methods are not suitable for the parallel readout of tens or hundreds of individual sensors. We have developed a MC sensor-array readout method based on phase-shifting interferometric microscopy (PSIM) which allows for the simultaneous monitoring of the response of all MCs within the field of view of the readout microscope optics. Based on this sensor technology, we have built an exhaled breath-analysis research instrument for the Point of Care Diagnostics Development Unit at the University of Leicester, UK. In this paper, we describe the PSIM readout system and the breath-analysis instrument that will be used to test sensor surface coatings and develop sensor sets with response patterns suitable for clear correlation to patients' health condition.

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Section: Methods: Phase-shifting Interferometric Microscopymentioning

confidence: 99%

Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays

Kelling

Huang²,

Capener³

et al. 2011

J. Breath Res.

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show abstract

“…1 Compound 19. Alkyne 12 (5 mg, 0.0147 mmol) and azide compound 18 39 (3.5 mg, 0.006 mmol) were suspended in a mixture of 1:1 t BuOH/water (0.1 mL) and stirred magnetically. A freshly prepared solution of sodium ascorbate (3.8 mg, 0.019 mmol) in water was added, followed by addition of a freshly prepared aqueous solution of CuSO 4 •5H 2 O (1.6 mg, 0.006 mmol).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors

Wei

Duca

et al. 2022

J. Med. Chem.

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Divalent inhibitors of the neuraminidase enzyme (NA) of the Influenza A virus were synthesized with vastly different spacers. The spacers varied from 14 to 56 atoms and were relatively rigid by way of the building blocks and their connection by CuAAC. As the ligand for these constructs, a Δ 4 -β- d -glucoronide was used, which can be prepared form N -acetyl glucosamine. This ligand showed good NA inhibitory potency but with room for improvement by multivalency enhancement. The synthesized compounds showed modest potency enhancement in NA activity assays but a sizeable potency increase in a 4-day cytopathic effect assay. The demonstration that the compounds can also inhibit hemagglutinin in addition to NA may be the cause of the enhancement.

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“…A promising way to detect a single chemical in complex mixtures or to differentiate similar mixtures from each other is to use array-based sensors, so-called artificial noses. − Initial artificial noses utilize mostly electrical − (e.g., metal oxide and polymer semiconductor arrays) and mechanical transducing elements − [e.g., differently functionalized microcantilevers and quartz crystal microbalance (QCM) and surface acoustic wave (SAW) sensors]. In these schemes, electrical or mechanical properties of each sensor element shift as a response to sorbed chemical species.…”

mentioning

confidence: 99%

Smelling in Chemically Complex Environments: An Optofluidic Bragg Fiber Array for Differentiation of Methanol Adulterated Beverages

2013

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A novel optoelectronic nose for analysis of alcohols (ethanol and methanol) in chemically complex environments is reported. The crossresponsive sensing unit of the optoelectronic nose is an array of three distinct hollow-core infrared transmitting photonic band gap fibers, which transmit a specific band of IR light depending on their Bragg mirror structures. The presence of alcohol molecules in the optofluidic core quenches the fiber transmissions if there is an absorption band of the analyte overlapping with the transmission band of the fiber; otherwise they remain unchanged. The cumulative response data of the fiber array enables rapid, reversible, and accurate discrimination of alcohols in chemically complex backgrounds such as beer and fruit juice. In addition, we observed that humidity of the environment has no effect on the response matrix of the optoelectronic nose, which is rarely achieved in gas-sensing applications. Consequently, it can be reliably used in virtually any environment without precalibration for humidity or drying the analytes. Besides the discussed application in counterfeit alcoholic beverages, with its superior sensor parameters, this novel concept proves to be a promising contender for many other applications including food quality control, environmental monitoring, and breath analysis for disease diagnostics.

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Sensor Array Composed of “Clicked” Individual Microcantilever Chips

Cited by 4 publications

References 46 publications

Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays

Breath analysis system based on phase-shifting interferometric microscopy readout of microcantilever arrays

Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors

Smelling in Chemically Complex Environments: An Optofluidic Bragg Fiber Array for Differentiation of Methanol Adulterated Beverages

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