Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19

Mougang, Yolande Ketchanji; Zazzo, Lorena Di; Minieri, Marilena; Capuano, Rosamaria; Catini, Alexandro; Legramante, Jacopo M.; Paolesse, Roberto; Bernardini, Sergio; Natale, Corrado Di

doi:10.1016/j.isci.2021.102851

Cited by 23 publications

(13 citation statements)

References 49 publications

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“…37 The main analytical equipment for these VOCs is gas chromatography and mass spectrometers. 38 This was first recognised by Hippocrates around 400 BD, and he reported several disease-specific odours from urine or sputum. The major sources of VOCs include breath, sweat, skin, urine, faeces and vaginal secretions.…”

Section: The Concept Of Volatile Organic Compounds (Vocs)mentioning

confidence: 97%

“…The complex biochemistry processes of COVID-19 such as SARS-CoV-2 entry and replication, humoral and cellular immunity, and cytokine storm, could induce the formation of VOCs or alter the normal VOCs profiles. 38 Also, the infection leads to a variation of the microbial flora in the lungs and, as a consequence, to a variation of exhaled metabolites. These VOCs are the targets of breath diagnostics and are used to assess health status without being invasive for patients.…”

Section: The Concept Of Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

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A comparison of Volatile Organic Compounds (VOCs) and the Concept of Gandha with special reference to Balagraha

M.K¹,

Nair²

2022

IRJAY

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The ancient science of Ayurveda has many unique concepts regarding the creation of the living, health issues, diseases and their treatment. These are distinctive and have the scope to incorporate modern development into them. During the trying times of the recent pandemic, there has been the development of sensors for detecting VOCs (volatile organic compounds) produced by COVID-infected individuals which helped to diagnose the disease swiftly to minimize its spread. The interaction between pathogenic viruses in respiratory tract infection and the body's microenvironment produces distinctive volatile organic compounds (VOCs). VOCs are gaseous molecules released as a product of metabolic processes in the body whose composition changes directly as a result of pathologic processes, such as an infection. This concept of different body odours in physiological and pathological conditions has been mentioned in Ayurveda thoroughly, especially in the context of Balagraha (which can be correlated to various infectious diseases). This shows the science's proficiency to be way ahead of its time. Thus, the incorporation of such distinctive ayurvedic concepts will help in the comprehensive development of the medical sciences

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Section: The Concept Of Volatile Organic Compounds (Vocs)mentioning

confidence: 97%

Section: The Concept Of Volatile Organic Compounds (Vocs)mentioning

confidence: 99%

A comparison of Volatile Organic Compounds (VOCs) and the Concept of Gandha with special reference to Balagraha

M.K¹,

Nair²

2022

IRJAY

View full text Add to dashboard Cite

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“…This study found that direct MS analysis of breath VOCs from COVID-19 patients had a 93% accuracy, which could lead to the development of the novel online approaches for large-scale COVID-19 screening [77]. For COVID-19 diagnosis, GC-MS analysis of breath VOC and blood metabolites has been recommended [81,82]. LC-MS has been a widely used technique for determination of exhaled breath condensate (EBC).…”

Section: Covid-19 Virus Detection Using Mass Spectroscopymentioning

confidence: 99%

Spectroscopic methods for COVID-19 detection and early diagnosis

Bedair

Okasha

Mansour

2022

Virol J

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The coronavirus pandemic is a worldwide hazard that poses a threat to millions of individuals throughout the world. This pandemic is caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), which was initially identified in Wuhan, China's Hubei provincial capital, and has since spread throughout the world. According to the World Health Organization's Weekly Epidemiological Update, there were more than 250 million documented cases of coronavirus infections globally, with five million fatalities. Early detection of coronavirus does not only reduce the spread of the virus, but it also increases the chance of curing the infection. Spectroscopic techniques have been widely used in the early detection and diagnosis of COVID-19 using Raman, Infrared, mass spectrometry and fluorescence spectroscopy. In this review, the reported spectroscopic methods for COVID-19 detection were discussed with emphasis on the practical aspects, limitations and applications.

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“…Volatile substances produced by pathogenic viruses like COVID-19 may serve as biomarkers. GC-MS analysis of breath VOC and blood metabolites has been proposed for COVID-19 diagnosis and research ( 26–28 ).…”

Section: Mass Spectrometrymentioning

confidence: 99%

Role of Breath Biopsy in COVID-19

Shekhawat

Banerjee

2022

The Journal of Applied Laboratory Medicine

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Background COVID-19 is a highly contagious respiratory disease that can be transmitted through human exhaled breath. It has caused immense loss and has challenged the healthcare sector. It has affected the economy of countries and thereby affecting numerous sectors. Analysis of human breath samples is an attractive strategy for rapid diagnosis of COVID-19 by monitoring breath biomarkers. Content Breath collection is a non-invasive process. Various technologies are employed for detection of breath biomarkers like mass spectrometry, biosensors, artificial learning, machine learning. These tools have low turn-around time, robustness, onsite results, Also, MS based approaches are promising tools with high speed, specificity, sensitivity, reproducibility and broader coverage as well as its coupling with various chromatographic separation techniques provides better clinical and biochemical understanding of COVID-19 using breath samples. Summary Herein, we have tried to review the MS based approaches as well as other techniques used for analysis of breath samples for COVID-19 diagnosis. We have also highlighted the different breath analyzers being developed for COVID-19 detection.

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Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19

Cited by 23 publications

References 49 publications

A comparison of Volatile Organic Compounds (VOCs) and the Concept of Gandha with special reference to Balagraha

A comparison of Volatile Organic Compounds (VOCs) and the Concept of Gandha with special reference to Balagraha

Spectroscopic methods for COVID-19 detection and early diagnosis

Role of Breath Biopsy in COVID-19

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