Sensitizers in photodynamic therapy

Parab, Shraddha; Achalla, Pavan Kumar; Yanamandala, Nitheesh; Singhvi, Gautam; Kesharwani, Prashant; Dubey, Sunil Kumar

doi:10.1016/b978-0-323-85595-2.00002-5

Cited by 5 publications

(2 citation statements)

References 67 publications

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“…Although the therapeutic potential of light-based treatments continues to increase, the lack of efficient dosimetry and appropriate illumination devices, together with inadequately defined treatment parameters, has also diminished the success of PDT [25]. Furthermore, each photosensitizer has its own advantages and disadvantages [26]. ICG and TBO as photosensitizers, along with exciting light, have been used against periodontal biofilms [27][28][29], .…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms of Staphylococcus aureus, Escherichia coli, and Candida albicans for Improved Antimicrobial Photodynamic Therapy

Afrasiabi,

Benedicenti,

Signore

et al. 2024

Bioengineering

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The efficiency of antimicrobial photodynamic therapy (PDT) might be improved by using multiple wavelengths. This study investigates the sensitivity of implant-adherent biofilms of Staphylococcus aureus, Escherichia coli, and Candida albicans to indocyanine green (ICG)-808 nm diode laser, toluidine blue O (TBO)-635 nm diode laser, and hydrogen peroxide (HP)-980 nm diode laser and their combination when irradiated with dual-wavelength laser irradiation (simultaneously 980–635 nm or 980–808 nm). After an incubation period of 72 h, the infected implants were randomly divided into seven different treatment modalities: Control, HP, HP-PDT, TBO-PDT, HP-TBO-PDT, ICG-PDT, and HP-ICG-PDT. After the treatments, the colony-forming units (CFUs)/mL and reactive oxygen species (ROS) generation were determined. All evaluated disinfection methods were significantly effective against the three investigated bacteria compared to the control. The combined treatment of HP-ICG-PDT or HP-TBO-PDT had the greatest antibacterial effect compared to each treatment alone. There were statistical differences between HP-ICG-PDT and ICG-PDT or HP-TBO-PDT and TBO-PDT for all three bacteria studied. PDT with simultaneous dual-wavelength laser irradiation is an efficient strategy to improve the therapeutic effect of PDT.

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Section: Discussionmentioning

confidence: 99%

Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms of Staphylococcus aureus, Escherichia coli, and Candida albicans for Improved Antimicrobial Photodynamic Therapy

Afrasiabi,

Benedicenti,

Signore

et al. 2024

Bioengineering

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“…Photodynamic therapy (PDT) is a clinically accepted, noninvasive, and highly selective therapeutic system for cancer treatment. It has been receiving significant attention since the 1970s for tumor treatment. − It is comprised of three major components: PS, source of light, and oxygen. Alone, these components are nontoxic, but in synergy they lead to a photochemical reaction that produces a greatly reactive singlet oxygen, which is responsible for death of cancer cell by apoptosis or necrosis.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Desai,

Choudhary,

Chowdhury

et al. 2024

Mol. Pharmaceutics

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The perpetuity of cancer prevalence at a global level calls for development of novel therapeutic approaches with improved targetability and reduced adverse effects. Conventional cancer treatments have a multitude of limitations such as nonselectivity, invasive nature, and severe adverse effects. Chemotherapy is also losing its efficacy because of the development of multidrug resistance in the majority of cancers. To address these issues, selective targeting-based approaches are being explored for an effective cancer treatment. Mitochondria, being the moderator of a majority of crucial cellular pathways like metabolism, apoptosis, and reactive oxygen species (ROS) homeostasis, are an effective targeting site. Mitochondria-targeted photodynamic therapy (PDT) has arisen as a potential approach in this endeavor. By designing photosensitizers (PSs) that preferentially accumulate in the mitochondria, PDT offers a localized technique to induce cytotoxicity in cancer cells. In this review, we intend to explore the crucial principles and challenges associated with mitochondria-targeted PDT, including variability in mitochondrial function, mitochondria-specific PSs, targeted nanocarrier-based monotherapy, and combination therapies. The hurdles faced by this emerging strategy with respect to safety, optimization, clinical translation, and scalability are also discussed. Nonetheless, mitochondria-targeted PDT exhibits a significant capacity in cancer treatment, especially in combination with other therapeutic modalities. With perpetual research and technological advancements, this treatment strategy is a great addition to the arsenal of cancer treatment options, providing better tumor targetability while reducing the damage to surrounding healthy tissues. This review emphasizes the current status of mitochondria-targeted PDT, limitations, and future prospects in its pursuit of safe and efficacious cancer therapy.

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Comparison of high power red-emitting diode laser designs for medical applications

Ryvkin,

Avrutin

2024

Opt Quant Electron

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A comparison is made between, on the one hand, the red-emitting laser structure currently widely used for medical applications and based on an ultranarrow waveguide layer with a compressively strained QW active layer in it and, on the other hand, the red emitting laser using a broadened asymmetric waveguide structure with a bulk active layer near the p-cladding, proposed by us. It is shown that the proposed design promises substantial improvements over the ultranarrow one including lower series and thermal resistances, and higher catastrophic degradation threshold, while maintaining relatively narrow far field and allowing the typical power required for medical applications to be achieved at lower currents, particularly at elevated temperatures.

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Sensitizers in photodynamic therapy

Cited by 5 publications

References 67 publications

Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms of Staphylococcus aureus, Escherichia coli, and Candida albicans for Improved Antimicrobial Photodynamic Therapy

Simultaneous Dual-Wavelength Laser Irradiation against Implant-Adherent Biofilms of Staphylococcus aureus, Escherichia coli, and Candida albicans for Improved Antimicrobial Photodynamic Therapy

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Comparison of high power red-emitting diode laser designs for medical applications

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