Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity

Sonesson, Andreas; Bartosik, Jacek; Christiansen, J; Roscher, Ingrid; La, Nilsson; Schmidtchen, Artur; Bäck, Ove

doi:10.2340/00015555-1465

Cited by 49 publications

(50 citation statements)

References 52 publications

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“…Another study on 619 adult patients from Sweden showed a correlation between the severity of AD and the combined IgE sensitisation to dust mites and yeasts such as Malassezia spp. and C. albicans (19).…”

Section: Discussionmentioning

confidence: 99%

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Glatz¹,

Buchner²,

Bartenwerffer³

et al. 2015

Acta Derm Venerol

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The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (> 100 kU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r = 0.549, p < 0.001) and children (r = 0.344, p = 0.005) and with Malassezia spp.-specific IgE in adults (r = 0.429, p = 0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.

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Section: Discussionmentioning

confidence: 99%

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Glatz¹,

Buchner²,

Bartenwerffer³

et al. 2015

Acta Derm Venerol

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“…AD is also more highly associated with sensitization to C. albicans , compared with other fungal species [26]. Increased Candida -specific IgE also correlates with severity of disease [32]. These findings suggest that C. albicans could be an unforeseen contributor to AD pathogenesis and supports a need for further fungal microbiota analysis on a larger scale.…”

Section: Fungal Microbiome Of the Skinmentioning

confidence: 99%

The emerging world of the fungal microbiome

Huffnagle

Noverr

2013

Trends in Microbiology

460

385

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The study of the fungal microbiota (‘mycobiome’) is a new and rapidly emerging field that lags behind our understanding of the bacterial microbiome. Every human has fungi as part of their microbiota, but the total number of fungal cells is orders of magnitude smaller than that of the bacterial microbiota. However, the impact of the mycobiome on human health is significant, especially as a reservoir for blooms of pathogenic microbes when the host is compromised and as a potential cofactor in inflammatory diseases and metabolic disorders.

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“…A key priority for allergy research will be to determine whether these apparent associations are confirmed by further unbiased, high-throughput sequencing methods; and if so, the extent to which the bacterial flora of mite pests may modulate conditions such as atopic dermatitis (Sonesson et al 2013). A key priority for allergy research will be to determine whether these apparent associations are confirmed by further unbiased, high-throughput sequencing methods; and if so, the extent to which the bacterial flora of mite pests may modulate conditions such as atopic dermatitis (Sonesson et al 2013).…”

Section: Outcomes and Perspectivesmentioning

confidence: 99%

Symbiosis in an overlooked microcosm: a systematic review of the bacterial flora of mites

et al. 2015

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A dataset of bacterial diversity found in mites was compiled from 193 publications (from 1964 to January 2015). A total of 143 mite species belonging to the 3 orders (Mesostigmata, Sarcoptiformes and Trombidiformes) were recorded and found to be associated with approximately 150 bacteria species (in 85 genera, 51 families, 25 orders and 7 phyla). From the literature, the intracellular symbiont Cardinium, the scrub typhus agent Orientia, and Wolbachia (the most prevalent symbiont of arthropods) were the dominant mite-associated bacteria, with approximately 30 mite species infected each. Moreover, a number of bacteria of medical and veterinary importance were also reported from mites, including species from the genera Rickettsia, Anaplasma, Bartonella, Francisella, Coxiella, Borrelia, Salmonella, Erysipelothrix and Serratia. Significant differences in bacterial infection patterns among mite taxa were identified. These data will not only be useful for raising awareness of the potential for mites to transmit disease, but also enable a deeper understanding of the relationship of symbionts with their arthropod hosts, and may facilitate the development of intervention tools for disease vector control. This review provides a comprehensive overview of mite-associated bacteria and is a valuable reference database for future research on mites of agricultural, veterinary and/or medical importance.

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Sensitization to Skin-associated Microorganisms in Adult Patients with Atopic Dermatitis is of Importance for Disease Severity

Cited by 49 publications

References 52 publications

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults

The emerging world of the fungal microbiome

Symbiosis in an overlooked microcosm: a systematic review of the bacterial flora of mites

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