Sensitization to profilin in the Central region of Portugal

Tavares, Beatriz; Machado, Daniel; Loureiro, Graça; Cemlyn-Jones, Jessica; Pereira, Celso

doi:10.1016/j.scitotenv.2008.08.013

Cited by 14 publications

(12 citation statements)

References 32 publications

(50 reference statements)

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“…79 Patients who are sensitized to profilin tend to also be sensitized to mugwort and ragweed pollen in addition to birch and grass pollen. 73 Profilin sensitization in pollen-allergic individuals is common in southern Europe with prevalence rates of 6% in Spain's Mediterranean coast, 11 21% in Portugal, 82 and 30% in Italy. 80,81 Fruit allergy to melon, watermelon, tomato, banana, pineapple, and orange may be considered a marker of profilin hypersensitivity (Table 5).…”

Section: Pathogenesismentioning

confidence: 99%

Oral Allergy Syndrome (Pollen-Food Allergy Syndrome)

Price

Ramachandran²,

Smith

et al. 2015

Dermatitis

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Oral allergy syndrome (OAS) or pollen-food allergy syndrome (PFS) is a hypersensitivity reaction to plant-based foods, manifesting most commonly with pruritus of the lips, tongue, and mouth. Unlike simple food allergy, OAS requires prior sensitization to a cross-reacting inhalant allergen rather than direct sensitization to a specific food protein. In this review, we summarize the clinical features and pathophysiology of OAS and provide an overview of known pollen-food associations.

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Section: Pathogenesismentioning

confidence: 99%

Oral Allergy Syndrome (Pollen-Food Allergy Syndrome)

Price

Ramachandran²,

Smith

et al. 2015

Dermatitis

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“…This study also showed that patients sensitized to pan-allergens can be identified by IgE reactivity to pollens to which they have had no significant exposure. Profilin sensitization without recognition of the major pollen marker allergens (such as Phl p 1, Phl p 5, Bet v 1, Ole e 1, Par j 1/2 or Art v 1) may therefore be used in clinical practice as a marker for non-clinically relevant polysensitization to pollen [80]. …”

Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

Profilins: Mimickers of Allergy or Relevant Allergens?

Santos

Ree

2011

Int Arch Allergy Immunol

139

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Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems to arise from pollen sensitization with later development of cross-reactive IgE antibodies against plant food (and possibly latex) profilins. The role of profilin in inducing allergic symptoms needs to be evaluated and raises important issues in allergy diagnosis due to cross-reactivity. IgE cross-reactivity among profilins is associated with multiple pollen sensitization and with various pollen-food syndromes. In respiratory allergy, sensitization to pollen to which the patient has virtually no environmental exposure has been identified as a manifestation of profilin sensitization. As a food allergen, profilin usually elicits mild reactions, such as oral allergy syndrome, is not modified by processing and is especially important in allergy to some fruits, such as melon, watermelon, banana, tomato, citrus fruit and persimmon. Purified natural and recombinant profilins for in vitro and in vivo allergy tests are helpful in the diagnostic work-up. Herein we review the current state of knowledge about the allergen profilin and its implications in the diagnosis and treatment of allergic diseases. We conclude that, although its role in triggering allergic symptoms is still controversial, profilin is undoubtedly a relevant allergen. As a pan-allergen, profilin is associated with multiple pollen sensitization and pollen-food-latex syndromes that the allergist has to be aware of in order to accomplish an accurate diagnosis and successful treatment of allergic diseases.

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“…Grasses pollens are the main cause of respiratory allergic disease in Europe, 1 mainly in the Mediterranean region. 2,3,4 In Portugal they are one of the pollen types most implicated in respiratory allergy. 12 In Beja, they are a dominant element of herbaceous vegetation and atmospheric pollen levels of this type are high.…”

Section: Introductionmentioning

confidence: 99%