Sensitization to local dust‐mite fauna in Singapore

Abstract

Asthma and/or allergic rhinitis patients were highly sensitized to the local dust-mite fauna. Thus, these dust mites should be considered important allergenic sources of this region.

Prevalence and severity of sensitization reaction to food and inhalant allergens among allergic patients from Jeddah city: Saudi Arabia

“…13 Many studies from hot and humid regions reported a high prevalence of mites allergy such as in Singapore, Malaysia and Thailand. [14][15][16] Similar conditions are found in Jeddah city with high prevalence of mites reactivity according to the present study.…”

Nuclear Magnetic Resonance Structure and IgE Epitopes of Blo t 5, a Major Dust Mite Allergen

“…tropicalis is a common dust mite in tropical regions, usually found together with either D. pteronyssinus or D. farinae, or both, and predominates in Singapore, Malaysia, Columbia, and Brazil (29 -32). Sensitization to B. tropicalis is highly prevalent in terms of occurrence and is strongly associated with allergenic diseases in these countries (33,34). The group 5 allergen, Blo t 5, is the major allergen in B. tropicalis and a study has shown that 43% of B. tropicalis-sensitive patients were allergic to Blo t 5 (9).…”

Structures of Two Major Allergens, Bla g 4 and Per a 4, from Cockroaches and Their IgE Binding Epitopes

“…5C). The docked ligand in Bla g 4 is not exposed to the solvent and the entrance to the ligand binding cavity seems to be closed by side chains from residues 3 group and epoxy group of JH III may also form hydrogen bonds with polar residues in the vicinity (Fig. 5E).…”

“…It has been reported that 44% of the 755 allergy clinic patients living in New York responded positive in skin tests to cockroach allergens (2). In Singapore, sensitization rates among patients with asthma and/or allergic rhinitis to cockroaches are 56.4% (Blattella germanica) and 59.5% (Periplaneta americana), second only to the dust mite (3). Both species of domestic cockroaches produce several potent allergens, including Bla g 1 and Per a 1 (food intake and digestion); Bla g 2 and Per a 2 (inactive aspartic protease); Per a 3 (arylphorin-like storage protein); Bla g 4 and Per a 4 (male pheromone transport lipocalin); Bla g 5 and Per a 5 (glutathione S-transferase); Bla g 6 and Per a 6 (troponin C); and Bla g 7 and Per a 7 (tropomyosin) (4).…”