Sensitization to four common inhalant allergens within 302 nuclear families

Kuehr, Joachim; Karmaus, Wilfried; Förster, Johannes; Frischer, Thomas; Hendel-Kramer, Anneliese; Moseler, Michael; Stephan, Volker; Urbanek, R.; Weiss, Kelly

doi:10.1111/j.1365-2222.1993.tb00900.x

Cited by 64 publications

(52 citation statements)

References 18 publications

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“…Skin prick testing was not performed in the parents [4, 5, 6, 7], but evaluation of the health questionnaires revealed no difference in the reported prevalence of allergy between immigrant and Dutch parents (table 2), though the prevalence of allergy in Surinam parents was relatively high (40%). Table 2 further shows that multiple positive skin prick reactions (two or more) were more prevalent in Moroccan and Surinam children (14.2 and 35.0%, respectively), as compared with Dutch and Turkish children (8.7 and 7.4%, respectively).…”

Section: Resultsmentioning

confidence: 99%

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The Prevalence of Allergic Sensitisation in Immigrant Children in the Netherlands

Amsterdam

Bischoff²,

Hady³

et al. 2004

Int Arch Allergy Immunol

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Background: Differences in the prevalence of allergic sensitisation have been reported in immigrant children living in the same urban environment. The purpose of this study is to investigate the prevalence of allergic sensitisation in school children of Dutch, Turkish and Moroccan origin. Methods: The prevalence of sensitisation to aero-allergens was assessed using the skin prick test in a non-selected sample of 512 children (response rate 54%) living in the same inner city district of Utrecht. In addition, exhaled nitric oxide (Fe_NO) was determined. Results: The prevalence of allergic sensitisation was dependent on the ethnic origin. As compared with Dutch children (19.1%), a higher prevalence of allergic sensitisation was observed in immigrant children for whom both parents were born in Turkey (23.6%, not significant) or Morocco (30.6%, p < 0.05). The prevalence of allergic sensitisation in Dutch children was nearly 2 times lower than the reported prevalence in German children. In all sensitised children, the mean Fe_NO value was significantly (p < 0.05) higher than in non-sensitised children, and the mean Fe_NO level was highest in Moroccan children sensitised to indoor allergens. Conclusion: In the Netherlands, immigrant children show a higher prevalence of allergic sensitisation as compared to Dutch children.

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Section: Resultsmentioning

confidence: 99%

“…Family history of allergy is the most prominent risk factor for allergic disease [4, 5, 6, 7], but other socio-demographic factors, like economic status, number of siblings and birth order [8], show strong associations as well.…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Allergic Sensitisation in Immigrant Children in the Netherlands

Amsterdam

Bischoff²,

Hady³

et al. 2004

Int Arch Allergy Immunol

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“…This panel of four allergens was expected to identify the majority of individuals with atopic sensitization to common allergens [24]. The observed associations with the use of QACs suggest that occupational exposure may induce sensitization to non-work-related allergens.…”

Section: Discussionmentioning

confidence: 99%

Disinfectant use as a risk factor for atopic sensitization and symptoms consistent with asthma: an epidemiological study

Preller

Doekes²,

Heederik³

et al. 1996

European Respiratory Journal

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Exposure to some nonallergenic compounds has been shown to increase the risk of atopic sensitization and asthmatic symptoms. In order to gain more insight into the largely unknown aetiology of respiratory symptoms in pig farmers, we studied the role of nonallergic exposure.We evaluated associations between chronic respiratory symptoms, specific and total serum immunoglobulin E (IgE) levels, use of disinfectants, and endotoxin exposure levels in a population of 194 Dutch pig farmers.Atopic sensitization (defined as increased production of IgE to common allergens) was found to occur more frequently in farmers who used disinfectants containing quaternary ammonium compounds (QACs) (odds ratio (OR) 7.4; 95% confidence interval (95% CI) 1.3-43.1). ORs for other disinfectants ranged 2.3-4.1 (NS). Atopic sensitization was not found to occur more frequently in farmers with a high endotoxin exposure. The use of disinfectants was only related to respiratory symptoms consistent with asthma in atopics. This is illustrated by the significantly elevated ORs for farmers with IgE to common allergens (house dust mite, grass pollen, birch pollen), and who used disinfectants containing QACs, in the total population and in a subgroup of the total population restricted according to bronchial hyperresponsiveness to histamine (symptomatics with a provocation dose of histamine producing a ≥10% decrease in forced expiratory volume in one second (PC10) ≤16 mg·mL -1 , compared with asymptomatics with a PC10 >16 mg·mL -1 ) (OR 4.4, 95% CI 1.3-14.6; and OR 8.2, 95% CI 1.6-42.6, respectively). Atopy and use of QACs and endotoxin exposure level taken individually were not associated with respiratory symptoms. A combination of atopic sensitization and high endotoxin exposure (>101 ng·m -3 ) was strongly associated with respiratory symptoms in the restricted population (OR 6.1; 95% CI 1.0-36.2).Our results suggest that occupational exposure to nonallergenic agents (disinfectants) may induce immunoglobulin E sensitization to common aeroallergens, and that the combination of atopy and exposure to nonallergenic agents (disinfectants and endotoxin) is an important risk factor for development of symptoms consistent with asthma. Eur Respir J., 1996Respir J., , 9, 1407Respir J., -1413 This study was part of the European Union concerted action "Epidemiology of occupational allergic asthma and exposure to bioaerosols", contract No. BMH1-CT94-1446.Allergic respiratory disorders, including asthma, are characterized by an increased production of allergen specific immunoglobulin E (IgE) antibodies. Sensitization, and subsequent development of allergic respiratory symptoms, depend on intrinsic and extrinsic factors. The inherited propensity to produce specific IgE antibodies in response to environmental allergens is of primary importance, and allergen exposure has been shown to be a relevant risk factor both for atopic sensitization and for the induction of respiratory symptoms in sensitized individuals [1,2]. However, not all genetically predispo...

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“…A large number of studies have evaluated parent-of-origin effects on the development of asthma and allergic susceptibility in offspring. There is strong evidence that a maternal history of allergic disease has more influence than paternal history over subsequent allergic phenotypes in offspring (18)(19)(20), and several birth cohort studies have demonstrated that maternal but not paternal history of asthma was an important predictor of subsequent wheeze in early childhood (21)(22)(23). Maternal history of asthma also appears to modify the effects of environmental factors that promote the development of asthma (24,25).…”

Section: Discussionmentioning

confidence: 99%