Sensitization to cross‐reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy

Ebo, Didier G.; Hagendorens, M. M.; Bridts, C.H.; Clerck, Luc S. De; Stevens, W. J.

doi:10.1111/j.1365-2222.2004.01837.x

Cited by 146 publications

(163 citation statements)

References 52 publications

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“…However it required the fundamental study of Mari [16] to anchor the clinical insigni cance of CCDs in the consciousness of the experts. Mari's conclusions were supported by a study on "mimickers of allergy", which concluded "Sensitization to pro lin and/or bromelain-type CCD, caused by pollen (timothy grass, mugwort) or hymenoptera venom allergens, can elicit false-positive IgE antibodies against natural rubber latex and apple" [1].…”

Section: Biological Signi Cance Of Plant/insect Ccdsmentioning

confidence: 57%

Coping with cross-reactive carbohydrate determinants in allergy diagnosis

Altmann¹

2016

Allergo J

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Section: Biological Signi Cance Of Plant/insect Ccdsmentioning

confidence: 57%

Coping with cross-reactive carbohydrate determinants in allergy diagnosis

Altmann¹

2016

Allergo J

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“…In most patients, diagnosis of NRL anaphylaxis can readily be established by quantification of sIgE (k82), skin tests, or both (77)(78)(79). Although these tests are highly reliable, results of are not always unequivocal (80), and some patients might need additional tests such as basophil activation (81)(82)(83) or challenge tests (84,85) to establish diagnosis.…”

Section: Natural Rubber Latexmentioning

confidence: 99%

Anaphylaxis during anaesthesia: diagnostic approach

Ebo¹,

Fisher²,

Hagendorens³

et al. 2007

Allergy

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Anaesthesiologists administer several drugs while providing general anaesthesia. Many of these drugs can elicit adverse drug reactions that fall apart into two major types. First, reactions that are usually dose-dependent and related to the pharmacological properties of the drug and/or its metabolites. Second, reactions that are unrelated to the drug's pharmacological characteristics and that are less dose-dependent. These reactions comprise drug intolerance, idiosyncratic reactions and drug-induced immune-mediated allergic and nonimmune-mediated so-called pseudo-allergic or anaphylactoid reactions. The terms anaphylactic and anaphylactoid, however, have been used inconsistently in the literature. Therefore, the nomenclature task force set up by the European Academy of Allergy and Immunology (EAACI) has proposed that anaphylactic-type reactions should be reclassified into allergic anaphylaxis and nonallergic anaphylaxis. Allergic anaphylaxis being further subdivided in IgE-mediated and non-IgE-mediated reactions (1).The exact prevalence of anaphylaxis during anaesthesia is difficult to ascertain. The estimated overall frequency has been reported to vary between 1 in 3500 and 1 in 13 000 procedures in French series (2, 3) and between 1 in 10 000 and 1 in 20 000 in an Australian study (4). The clinical manifestation of these reactions is not infrequently an almost immediate generalized response with bronchospasm and hypotension. The degree of severity varies and does not allow differentiation between an IgE-mediated or non-IgE mediated reaction resulting from nonspecific mediator release (5). The mortality from these reactions is in the range from 3 to 6%, and an additional 2% of patients experience significant residual brain damage (4).Diagnosis of anaphylaxis during anaesthesia is not always straightforward. It can be hampered as a broad spectrum of different drugs can elicit heterogeneous allergic and nonallergic reactions with distinct and sometimes unclear pathological mechanisms. Problems are certainly compounded as multiple drugs need to be administered during general anaesthesia. In addition, nonanaesthesia related drugs or procedures (e.g. disinfection) are sometimes administered/performed in the perioperative period and can also be the cause of an allergic reaction.In addition, none of the available diagnostic tests demonstrates absolute accuracy. False-positive test Correct management of anaphylaxis during anaesthesia requires a multidisciplinary approach with prompt recognition and treatment of the acute event by the attending anaesthesiologist, and subsequent determination of the responsible agent(s) with strict avoidance of subsequent administration of all incriminated and/or cross-reacting compounds.However, correct identification of the causative compound(s) and safe alternatives is not always straightforward and, too often, not done.This review is not intended to discuss acute management of anaesthesia-related anaphylaxis but summarizes the major causes of anaphylaxis during anaesthesia and the di...

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“…Al igual que las PR son consideradas lábiles a la digestión gástrica, por lo que se han asociado con SAO. 6,11,12 El común denominador de todas esas proteí-nas es su labilidad, la cual limita su potencial para causar síntomas sistémicos, sin embargo, pueden ocurrir. Por este motivo se hicieron estudios en los pacientes con SAO y reacciones sistémicas frecuentes, los cuales revelaron un nuevo grupo de panalér-genos: las proteínas de transferencia lipídica (LTP).…”

Section: Antecedentesunclassified

“…Características clínicas del síndrome de alergia oral en la población estudiada de acuerdo con la historia clínica tos más implicados son la manzana (37 %), el durazno (27 %), el plátano (23 %), el camarón (18 %) y el kiwi (18 %) (5). En nuestra investigación, al igual que los registros internacionales, la manzana (55 %) y el durazno (48 %) fueron los más comunes, 7,8,9,10,11,12,13,14 sin embargo, el plátano, que no fue un alimento común en otras poblaciones, ocupó el tercer lugar en orden de frecuencia (48 %), lo cual coincide con los estudios nacionales de Rodríguez et al, donde también ocupó el tercer lugar (23 %).…”

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Perfil clínico-epidemiológico del síndrome de alergia oral en población de 6 a 18 años

Azamar-Jácome

Azamar-Jácome²,

Borjas-Aguilar

et al. 2017

RAM

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Background: Oral allergy syndrome (OAS) or pollen-fruit syndrome is a type of food allergy. Its characteristics and associated allergens vary according to the studied population. There are few studies in Mexico about this topic, none in children. Objective: To describe clinical and epidemiological characteristics of OAS among children in Mexico. Methods: A descriptive, observational, transversal and prospective study was conducted. We included every patient from 6 to 18 years old with diagnostic suspicion of OAS, in which complete clinical history, skin test to food and pollens, and oral food challenge were performed. Results: We found a prevalence of 5.3% (29 patients): 55% were males. Average age was 10 ± 3 years, and average number of food implicated were 6.8 ± 4.1. Apple, peach and banana, were the most frequent food associated, and sensitization to oak and European privet, the more prevalent pollens found in OAS. Conclusion: OAS is a common type of food allergy, transient and mild in nature. In more than 90% of the cases is associated with allergic rhinitis and sensitization to pollens. In our population, profilins may be involved in its pathogenesis. However, more studies are required to prove this.

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Sensitization to cross‐reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy

Cited by 146 publications

References 52 publications

Coping with cross-reactive carbohydrate determinants in allergy diagnosis

Coping with cross-reactive carbohydrate determinants in allergy diagnosis

Anaphylaxis during anaesthesia: diagnostic approach

Perfil clínico-epidemiológico del síndrome de alergia oral en población de 6 a 18 años

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