Sensitization patterns in Compositae‐allergic patients with current or past atopic dermatitis

Paulsen, Evy; Andersen, Klaus Ejner

doi:10.1111/cod.12035

Cited by 31 publications

(20 citation statements)

References 49 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Weak allergens, such as lanolin alcohol, can result in sensitisation following exposure over many years . Increasingly, SL mix sensitivity has been associated with AD, and may be mediated via inhalation of airborne pollen or usage of topical products with compositae allergens …”

Section: Discussionmentioning

confidence: 65%

Allergic contact dermatitis in atopic individuals: Results of a 30‐year retrospective study

et al. 2019

View full text Add to dashboard Cite

Background: The association between atopic dermatitis (AD) and contact allergy, remains unclear, with studies to date showing conflicting results.Objectives: To investigate the prevalence of contact allergy in AD individuals compared to those without AD.Methods: Results of 46 250 patients patch tested in a single centre over a span of 30 years were reviewed, comparing those with AD with those without AD. Collected data were analysed with corrections for multiple confounding variables, including date of patch testing to account for changes in allergens tested over the period.Results: Nine allergens showed a statistically significant difference between the two groups. Contact allergy to nickel, cobalt and primin was less likely to arise in those with AD, whilst substances found in topical dermatological products were more likely to be associated with AD.Conclusions: This is the largest single centre study of contact sensitization in atopy reported to date. The previously reported association between contact allergy to sesquiterpene lactone and AD is reinforced. The decreased incidence of metal allergy suggests distinct immunological effector mechanisms in sensitization to these allergens. In keeping with previous publications, exposure to topical treatments for AD can result in sensitisation and contact allergy and clinicians should consider patch testing in AD individuals who report worsening of their skin despite continued treatment with topical medicaments.

show abstract

Section: Discussionmentioning

confidence: 65%

Allergic contact dermatitis in atopic individuals: Results of a 30‐year retrospective study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Previous studies and case reports have suggested an increased risk of sensitization to plant allergens in patients with AD, but the causality of this relationship is unclear. Although few of the reviewed studies provide information on contact allergy to sesquiterpene lactone mix and compositae mix, positive reactions were significantly associated with AD.…”

Section: Discussionmentioning

confidence: 97%

Contact allergy in children with atopic dermatitis: a systematic review

et al. 2017

View full text Add to dashboard Cite

The importance of contact allergy in children with atopic dermatitis is frequently debated. Previously, patients with atopic dermatitis were believed to have a reduced ability to produce a type IV immunological response. However, this belief has been challenged and authors have highlighted the risk of underestimating and overlooking allergic contact dermatitis in children with atopic dermatitis. Several studies have been published aiming to shed light on this important question but results are contradictory. To provide an overview of the existing knowledge, we systematically reviewed studies that report frequencies of positive patch test reactions in children with atopic dermatitis. We identified 436 manuscripts of which 31 met the inclusion criteria. Although the literature is conflicting, it is evident that contact allergy is a common problem in children with atopic dermatitis.

show abstract

“…A periumbilical, neck and wrist, or earlobe dermatitis might indicate exposure to nickel in the claps of jeans, necklace, bracelets, or earrings [28]. It is important to always ask about use of natural remedies in parallel to prescribed treatments, which may sustain the symptoms of ACD in children [29], with particular attention on the use of essential oil and Compositae dermatitis, which may appear as hand eczema in young children [30].…”

Section: Clinical Pictures and Patch Testing In Ad Childrenmentioning

confidence: 99%