Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats

Nikaido, Takato; Moriya, Takuya; Takabayashi, Reiko; Akigama, Masashi; Shibata, Shigenobu

doi:10.1016/s0006-8993(99)01955-1

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Recently it was reported that sensitization to repeated cocaine exposure, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies mutant for timeless (Andretic et al, 1999) We demonstrated that the MAP-induced free-running oscillation of rat locomotion with drinking application of MAP exhibits a sensitization phenomenon (Nikaido et al, 1999). Therefore, the next progressive step was to examine whether MAP induces Per expression in the CPu, and whether sensitization is involved in MAP-induced Per expression but not timeless expression.…”

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confidence: 77%

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine

et al. 2001

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Methamphetamine (MAP) causes the sensitization phenomena not only in MAP-induced locomotor activity, dopamine release, and Fos expression, but also in MAP-induced circadian rhythm. Cocaine-induced sensitization is reportedly impaired in Drosophila melanogaster mutant for the Period (Per) gene. Thus, sensitization may be related to induction of the Per gene. A rapid induction of mPer1 and/or mPer2 in the suprachiasmatic nucleus after light exposure is believed to be necessary for light-induced behavioral phase shifting. Although the caudate/putamen (CPu) expresses mPer1 and/or mPer2 mRNA, the function of these genes in this nucleus has not yet been elucidated. Therefore, we examined whether MAP affects the expression of mPer1 and/or mPer2 mRNA in the mouse CPu. Injection of MAP augmented the expression of mPer1 but not mPer2 or mPer3 in the CPu, and this MAP-induced increase in mPer1 expression lasted for 2 h. Also, the MAP-induced increase of mPer1 mRNA was strongly antagonized by pretreatment with a dopamine D1 receptor and N-methyl-D-aspartate (NMDA) receptor antagonist, but not by a D2 receptor antagonist. Interestingly, application of either the D1 or the D2 agonist alone did not cause mPer1 expression. The present results demonstrate that activation of both NMDA and D1 receptors is necessary to produce MAP-induced mPer1 expression in the CPu. Repeated injection of MAP caused a sensitization in not only the locomotor activity but also mPer1 expression in the CPu without affecting the level of mPer2, mPer3, or mTim mRNA. Thus, these results suggest that MAP-induced mPer1 gene expression may be related to the mechanism for MAP-induced sensitization in the mouse.

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confidence: 77%

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine

et al. 2001

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“…Previous studies have demonstrated that both D 1 and NMDA receptor subtypes contribute to the behavioural sensitization induced by chronic MAP administration (Ujike et al ., 1989; for a review, seeSripada et al ., 2001). Further, one of our recent studies demonstrated the sensitization phenomenon in relation to the free‐running rhythm induced by ingested MAP (Nikaido et al ., 1999). The amplitude of mPer1 and mPer2 expression in the striatum at ZT 8 increased following daily MAP injection, suggesting that the daily entrainment signals associated with MAP injection may strengthen oscillatory force.…”

Section: Discussionmentioning

confidence: 99%

“…As a previous study demonstrated that a 2-mg/kg dose of MAP was enough to cause mPer1 gene expression and sensitization in mice (Nikaido et al, 1999(Nikaido et al, , 2001 and anticipation in rats , this dose was selected for the present study.…”

Section: Drug and Injection Schedulementioning

confidence: 99%

Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse

Iijima

Nikaido

Akiyama

et al. 2002

Eur J of Neuroscience

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111

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While the suprachiasmatic nucleus (SCN) coordinates the majority of daily rhythms, some circadian patterns of expression are controlled from outside of the SCN. These include responses to daily methamphetamine (MAP) injection, or daily restricted feeding. The mechanisms underlying these SCN‐independent circadian rhythms are unknown. A circadian oscillation in the expression of mPer1 and/or mPer2, mouse period, in the SCN is considered necessary to generate an SCN‐dependent circadian rhythm. Therefore, in this experiment, we examined the association between mPer gene expression and the MAP‐induced, SCN‐independent circadian rhythm. Acute injection of MAP caused an elevation of mPer1, mBmal1, and mNpas2 gene expression in the striatum and mPer1 in the liver. Daily MAP injection at a fixed time for 6 days shifted the rhythmic mPer1 and mPer2 expression in the striatum from a nocturnal to a diurnal rhythm, but failed to affect that in the SCN. Although lesion of the SCN ‘flattened’mPer gene oscillation in the striatum and liver, daily MAP injection caused both behavioural and mPer gene expression rhythms. Daily MAP injection at variable injection intervals (12–36 h) for 6 days, however, failed to produce mPer gene rhythm in the striatum. Daily repeated MAP signals may strengthen the oscillatory force of SCN‐independent circadian behavioural and molecular rhythms. The present results suggest that daily oscillation of mPer genes outside the SCN is closely associated with the regulation of SCN‐independent rhythms. Thus, the present experiment highlights strongly the important role of clock gene expression, in the brain, that underlies the circadian behavioural rhythm.

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“…In Drosophila, disruption of Per, Clock, and Cycle genes blocked the sensitization effect of repeated exposures of the flies to cocaine (Andretic et al, 1999). In rodents, chronic methamphetamine treatment desynchronized the locomotor activity rhythm of rats (Nikaido et al, 1999) and mice (Masubuchi et al, 2000). The circadian rhythms of Per and BMAL1 gene expression were completely phase-reversed by methamphetamine in mice, specifically in the CPu and parietal cortex, but not in the nucleus accumbens and suprachiasmatic nucleus (Masubuchi et al, 2000).…”

Section: Clock Genes Per1 and Per2mentioning

confidence: 97%

Differential gene expression in the rat caudate putamen after “binge” cocaine administration: Advantage of triplicate microarray analysis

Yuferov

Kroslak

LaForge

et al. 2003

Synapse

139

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Rat genome U34A (Affymetrix) oligonucleotide microarrays were used to analyze changes in gene expression in the caudate putamen (CPu) of Fischer rats induced by 1 and 3 days of "binge" cocaine (or saline) administration. A triplicate array assay of pooled RNA of each treatment group was used to evaluate the technical variability and sensitivity of microarrays. Cocaine-regulated genes were identified using the Affymetrix MAS 5.0 and Data Mining Tool v. 3. Eighty-nine upregulated and eight downregulated genes/ESTs were found after 1 day of "binge" cocaine. Following 3 days of cocaine treatment we identified 21 upregulated and 17 downregulated genes/ESTs. RNase protection assays of selected genes confirmed reliability of changes identified by the microarrays at the level of > or =1.40-fold increase. Many genes upregulated in the CPu by cocaine were immediate early genes for transcription factors and for "effector" proteins (e.g., vesl/Homer1a, Arc, synaptotagmin IV). Acute "binge" cocaine also increased mRNA levels for glutamate receptor GluR2, dopamine receptor D1, and a number of phosphatases. Genes downregulated by cocaine include several genes associated with energy metabolism in mitochondria, as well as the phosphatydylinositol-4 kinase and the regulator of G-protein signaling protein 4 (RGS4). A differential expression of somatostatin receptor SSTR2, not known to be a cocaine-responsive gene, as well as the clock gene Per2, were found by microarrays and confirmed by RNase protection assay. These results demonstrate the potential of microarrays in profiling gene expression with > or =40% increase or > or =14% decrease in mRNA levels for discovery of novel cocaine-responsive genes.

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Sensitization of methamphetamine-induced disorganization of daily locomotor activity rhythm in male rats

Cited by 7 publications

References 19 publications

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine

Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine

Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse

Differential gene expression in the rat caudate putamen after “binge” cocaine administration: Advantage of triplicate microarray analysis

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