Sensitization of glioblastoma cancer cells to radiotherapy and magnetic hyperthermia by targeted temozolomide-loaded magnetite tri-block copolymer nanoparticles as a nanotheranostic agent

Minaei, Soraya Emamgholizadeh; Khoei, Samideh; Khoee, Sepideh; Mahdavi, Seied Rabi

doi:10.1016/j.lfs.2022.120729

Cited by 18 publications

(10 citation statements)

References 59 publications

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“…On the other hand, hyperthermia can act as a synergist with radiotherapy and chemotherapy. High temperature affects the stability and function of DNA and proteins in cancer cells, making it more difficult to maintain homeostasis and increase the permeability of the cell membrane, which greatly reduces the resistance of cancer cells to radiation and chemotherapy drugs ( Minaei et al, 2022 ; Zeng et al, 2022 ). In situ cancer ablation techniques, such as radiofrequency ablation, microwave ablation, and focused energy centered ultrasound ablation, have attracted wide attention because they can perform local minimally invasive treatment of unresectable cancer ( Cazzato et al, 2021 ; Habibi et al, 2021 ).…”

Section: Hydrogels Can Be Used In Multiple Treatments For Cancermentioning

confidence: 99%

Hydrogel systems for targeted cancer therapy

et al. 2023

Front. Bioeng. Biotechnol.

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When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.

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Section: Hydrogels Can Be Used In Multiple Treatments For Cancermentioning

confidence: 99%

Hydrogel systems for targeted cancer therapy

et al. 2023

Front. Bioeng. Biotechnol.

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“…Recent studies include the work by Minaei and colleagues [ 145 ], where theragnostic folic-acid-conjugated TMZ-loaded SPION@poly(ethylene glycol)–poly(butylene adipate)–poly(ethylene glycol) (PEG-PBA-PEG) nanoparticles (TMZ-MNP-FA NPs) were synthesized to use as MRI contrast agents and enhance hyperthermia and radiotherapy. Particles exhibited a spherical shape, low polydispersity (PdI = 0.26), and a maximum size under 50 nm.…”

Section: Treatmentmentioning

confidence: 99%

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

et al. 2023

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Glioblastoma multiforme (GBM) remains a challenging disease, as it is the most common and deadly brain tumour in adults and has no curative solution and an overall short survival time. This incurability and short survival time means that, despite its rarity (average incidence of 3.2 per 100,000 persons), there has been an increased effort to try to treat this disease. Standard of care in newly diagnosed glioblastoma is maximal tumour resection followed by initial concomitant radiotherapy and temozolomide (TMZ) and then further chemotherapy with TMZ. Imaging techniques are key not only to diagnose the extent of the affected tissue but also for surgery planning and even for intraoperative use. Eligible patients may combine TMZ with tumour treating fields (TTF) therapy, which delivers low-intensity and intermediate-frequency electric fields to arrest tumour growth. Nonetheless, the blood–brain barrier (BBB) and systemic side effects are obstacles to successful chemotherapy in GBM; thus, more targeted, custom therapies such as immunotherapy and nanotechnological drug delivery systems have been undergoing research with varying degrees of success. This review proposes an overview of the pathophysiology, possible treatments, and the most (not all) representative examples of the latest advancements.

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“…Treatment of cancer cells with drug‐loaded nanoparticles under 808 nm laser radiation and x‐ray beam showed the highest toxicity. Finally, the researchers discovered that combining carrier‐based chemotherapy with hyperthermia and radiation resulted in greater anticancer effectiveness than single‐ or two‐modality therapies (Alamzadeh et al, 2020; Minaei et al, 2022).…”

Section: Thermo‐chemo‐radiotherapy Approaches Against Cancermentioning

confidence: 99%

The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer

Shirvalilou,

Tavangari,

Parsaei

et al. 2023

WIREs Nanomed Nanobiotechnol

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A pivotal cause of death in the modern world, cancer is an insidious pathology that should be diagnosed at an early stage for successful treatment. Development of therapeutic interventions with minimal invasiveness and high efficacy that can discriminate between tumor and normal cells is of particular interest to the clinical science, as they can enhance patient survival. Nanoparticles are an invaluable asset that can be adopted for development of such diagnostic and therapeutic modalities, since they come in very small sizes with modifiable surface, are highly safe and stable, and can be synthesized in a controlled fashion. To date, different nanoparticles have been incorporated into numerous modalities such as tumor‐targeted therapy, thermal therapy, chemotherapy, and radiotherapy. This review article seeks to deliver a brief account of recent advances in research and application of nanoparticles in hyperthermia‐based cancer therapies. The most recent investigations are summarized to highlight the latest advances in the development of combined thermo‐chemo‐radiotherapy, along with the challenges associated with the application of nanoparticles in cancer therapy.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Sensitization of glioblastoma cancer cells to radiotherapy and magnetic hyperthermia by targeted temozolomide-loaded magnetite tri-block copolymer nanoparticles as a nanotheranostic agent

Cited by 18 publications

References 59 publications

Hydrogel systems for targeted cancer therapy

Hydrogel systems for targeted cancer therapy

Highlighted Advances in Therapies for Difficult-To-Treat Brain Tumours Such as Glioblastoma

The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer

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