“…Because excitability increases of spinal second-order neurons have been repeatedly observed in animals following tissue injury, inflammation or chemical irritants (McMahon and Wall, 1984, Cook, et al, 1987, Woolf and King, 1990, Simone, et al, 1991, it has been proposed that prolonged or intense C-nociceptor activation leads to changes in central processing such that nociceptive dorsal horn neurons (i.e. spV in our study) show enhanced responses to Aβ low threshold mechanoreceptors (central sensitization) (Simone, et al, 1989, Woolf and King, 1990, Woolf, et al, 1994.…”