Sensitization, Immunological Tolerance and Desensitization of Guinea Pigs to Neoarsphenamine III.

Frey, Joachim; Weck, A.L. de; Geleick, H.

doi:10.1159/000229828

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…This type of tolerance has been called the Sulzberger-Chase phe nomenon [6,15,17,31,33]. The so-induced unresponsiveness is specif ic, usually long-lasting and may be due, according to the clonal selective theory of antibody production, to the annihilation or to a specific immu nological inhibition of preexisting antigen-sensitive cells.…”

Section: Introductionmentioning

confidence: 99%

The Induction of Immunological Tolerance During the Primary Response

Frey¹,

Weck²,

Geleick³

et al. 1972

Int Arch Allergy Immunol

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By injecting adult guinea pigs intravenously with dinitrochlo-robenzene sulfonate (DNBSO₃) 2 to 24 h after applying a sensitizing epicutaneous dose of dinitrochlorobenzene (DNCB), the production of PCA-detectable anti-DNP antibodies and the induction of contact hypersensitivity to DNCB is strongly depressed for over 14 weeks. The proportion of animals acquiring this state of specific unresponsiveness as well as its stability against a second sensitizing attempt with DNCB alone are clearly dependent on the dose of DNBSO₃ injected and on the time interval elapsing between both hapten applications. However, the tolerogenic effect of DNBSO₃ is stronger when injected some weeks before sensitization. The results obtained are discussed on the basis of current concepts on the relationship between antigen and immunocompetent cells. The possibilities to interpret our findings by means of reversible blocking or affinity labelling of cellular receptors, specific annihilation of antigen-sensitive cells or immune deviation are considered.

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Section: Introductionmentioning

confidence: 99%

The Induction of Immunological Tolerance During the Primary Response

Frey¹,

Weck²,

Geleick³

et al. 1972

Int Arch Allergy Immunol

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Topical Use of Mechlorethamine in the Treatment of Psoriasis

Taylor¹,

Halprin²

1972

Arch Dermatol

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The Induction of Tolerance to Allergenic Chemicals *

Chase

1982

Annals of the New York Academy of Sciences

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The first recognition of tolerance and partial tolerance to attempted sensitization with simple allergenic chemicals is described. A proper designation would be the Frei-Sulzbeger-Chase phenomenon. Coupling with self occurs in these experiments; there is not only resistance to developing contactant-type sensitivity but also to synthesis of immunoglobulins toward hapten-self complexes. The onset of tolerance is initiated by small doses of haptens. Various facets of these investigations speak strongly against a concept of clonal deletion as an explanation. The concept of the relative numbers of suppressor and effector cells also argues against clonal deletion. Evidence exists that tolerance can be transferred to syngeneic animals by cells during parabiosis (Polak, this volume). Contact sensitivity can be imposed on a tolerized guinea pig through a transfer of cells from outbred sensitized donors, but the tolerance remains after the transferred cells have been rejected. Tolerance could not be overcome in inbred guinea pigs by infusing normal or functionally "labeled" cell populations from close relatives before attempting sensitization, a fact that supports the existence of overwhelmingly large numbers of suppressor cells. Various routes of application have been explored to find a way to establish the tolerant state. The most successful are (1) feeding of small doses and (2) two intravenous injections of massive doses of DNP- or TNP-benzene sulfonates. Several other methods will effect tolerance in about half the animals, but experimental sensitization is the only method that will locate the tolerized animals.

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Sensitization, Immunological Tolerance and Desensitization of Guinea Pigs to Neoarsphenamine III.

Cited by 3 publications

References 13 publications

The Induction of Immunological Tolerance During the Primary Response

The Induction of Immunological Tolerance During the Primary Response

Topical Use of Mechlorethamine in the Treatment of Psoriasis

The Induction of Tolerance to Allergenic Chemicals *

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