Sensitization for audiogenic seizures in two strains of mice and their F<sub>1</sub> hybrids

Chen, Chia-Shong

doi:10.1002/dev.420060207

Cited by 34 publications

(5 citation statements)

References 9 publications

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“…This audiosensitivity after priming can last from 3 days to 20 weeks, but its effects are influenced by age and the interval between priming and subsequent sound exposure. It has also been shown that other acoustic stimuli such as fire bells, telephone bells, banging of metal cages, electric drills, and barking dogs greatly changed the incidence and severity of the convulsions in C F I (SW) mice (Iturrian & Fink, 1968a, 19686;Chen, 1973). Various reports have shown optimal conditions for different strains, and the detailed physiological and developmental changes that priming produces (Boggan, Freedman, Love11 & Schlesinger, 1971; Iturrian, 1973;Iturrian & Fink, 1969;Iturrian & Johnson, 1971 ;Saunders, 1974;Saunders & Hirsch, 1976).…”

Section: ( I ) M I C E ( a ) Audiogenic Seizuresmentioning

confidence: 99%

Sound and Its Significance for Laboratory Animals

Gamble

1982

Biological Reviews

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Summary 1. Several methods of varying accuracy have been used to assess what sounds small laboratory animals such as rodents are capable of hearing. Most rodents can detect sounds from 1000 Hz (the frequency of the Greenwich Time Signal) up to 100000 Hz, depending on the strain, with usually one or more commonly two peaks of sensitivity within this range. Dogs can detect sound most easily from 500 Hz to 55000 Hz, depending on the breed. 2. Rodents also produce sound signals as a behavioural response and for communication in a variety of situations. Ultrasonic calls in the range 22000–70000 Hz are the main communicating pathway during aggressive encounters, mating, and mothering. Similar calls have also been recorded from isolated animals associated with inactivity, rest and possibly even sleep. 3. Very loud sounds cause seizures in rats and mice, or can make them more susceptible to other sounds later in life. This effect is possible even when animals are fully anaesthetized. Sound tends to startle and reduce activity in several species of animal. Even offspring of mice that have been sound‐stressed exhibit abnormal behaviour patterns. Sounds also elicit various responses in rats from increasing aggression to making them more tolerant to electric shocks. 4. Levels of sound above 100 dB are teratogenic in several species of animals and several hormonal, haematological and reproductive parameters are disturbed by sounds above 80 dB. When rats are chemically deafened the disturbance to their fertility disappears. Lipid metabolism is disrupted in rats when exposed to over 95 dB of sounds, leading to increases in plasma triglycerides. Atherosclerosis can be produced in rabbits by similar levels of sound. 5. It has also been shown in guinea pigs and cats that hearing damage is governed by the duration as well as the intensity of the sound and is irreversible. Work on chinchillas hs demonstrated that sounds above 95 dB lead to this injury, but that sounds of 80 dB have no permanent effect on hearing sensitivity.

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Section: ( I ) M I C E ( a ) Audiogenic Seizuresmentioning

confidence: 99%

Sound and Its Significance for Laboratory Animals

Gamble

1982

Biological Reviews

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“…Our results show that morphine can suppress the incidence and severity of priming-induced audiogenic seizures in normally seizure-resistant BALB/c mice (Chen, 1973). Naloxone can reverse this suppression of seizures by morphine and thus suggests that morphine is acting via a specific receptor.…”

Section: Discussionmentioning

confidence: 70%

“…Twenty-one day old (±1 day) BALB/c mice were primed by 25 s exposure to a bell of intensity 131 dB re 0.0002 dyn cm-2 and tested for seizures 9 days (± 1 day) later by re-exposure to the same acoustic stimulus for a maximum of 60 s or until seizure occurred. The parameters for priming in this line of mice have been described elsewhere (Chen;. The incidence of four stages of audiogenic seizures was recorded (wild running, clonic seizure, tonic seizure and death) as were the latencies of onset of the first two stages.…”

Section: Methodsmentioning

confidence: 99%

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EFFECT OF MORPHINE AND NALOXONE ON PRIMING‐INDUCED AUDIOGENIC SEIZURES IN BALB/c MICE

Chen

Gates

Reynoldson

1976

British J Pharmacology

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“…In the C57BL/6 mouse, a sharply defined sensitive or critical period, peaking at 16-20 days of age, exists for acoustic priming for audiogenic seizures (Boggan, Freedman, Lovell, & Schlesinger, 1971;Henry, 1967;Henry & Bowman, 1970a, 1970bSaunders & Hirsch, 1976;Schreiber & Graham, 1976). The BALB/c mouse also appears to have a similar, sharply defined early sensitive or critical period for acoustic priming for audiogenic seizures (Chen, 1973). The C57BL/6 and BALB/c share another characteristic: progressive hearing loss which begins before adulthood (Henry & Chole, 1980;Rails, 1967).…”

Section: Discussionmentioning

confidence: 99%

Noise and the young mouse: Genotype modifies the sensitive period for effects on cochlear physiology and audiogenic seizures.

Henry¹

1984

Behavioral Neuroscience

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A sharply defined "critical period" has been described for the young C57BL/6 mouse, during which acoustic trauma will profoundly alter subsequent auditory behavior (audiogenic seizures, acoustic startle reflex). In several genotypes and species, a broader "sensitive period" exists, during which acoustic trauma is most damaging to cochlear functions in the young ear. In order to examine the correspondence of these two events, C57BL/6 and CBA inbred mice, at eight ages ranging from 12 to 54 days, were exposed to 2 min of a 124-dB (SPL) octave band noise (8-16 kHz). A noninvasive electrocochleographic technique was used to assess cochlear microphonic (CM) and action potential (AP) thresholds in exposed mice and their nonexposed littermate controls. This allowed cochlear functional measures and behavioral tests (susceptibility to audiogenic seizures) to be made in the same animals. Noise has no observable effect on the 12-day-old CBA mouse, produced a maximal threshold elevation (47 dB for AP, 28 dB for CM) at 30-36 days, with the effect declining to nearly half of this value in 54-day-old subjects. Susceptibility to audiogenic seizures in the exposed CBA mice was greatest at the peak of this sensitive period for cochlear damage (r = .95). C57BL/6 mice also appeared unaffected when noise exposure occurred at 12 days of age; they had maximal AP (23 dB) and CM (17 dB) threshold elevations at 36 days, and 54-day-old mice had an 18-dB elevation of the AP and their CM was no longer affected. Susceptibility to audiogenic seizures was greatest in C57BL/6 mice exposed to noise at 18 days, and it did not correspond with the sensitive period for cochlear damage (r = .21). Therefore, both genotypes have a sensitive period for the effects of noise trauma on the CM and AP, the CBA has a sensitive period for acoustic priming for audiogenic seizures, and the C57BL/6 has a critical period for acoustic priming. Genetic differences in age-related losses of central nervous system auditory functions are postulated as being responsible for these behavioral differences. These data are compared with known auditory functions of the SJL and BALB/c mouse strains in order to explain genetically determined differences of the sensitive (or critical) period of acoustic priming, and for the length of time the mice subsequently remain susceptible to audiogenic seizures.

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Sensitization for audiogenic seizures in two strains of mice and their F₁ hybrids

Cited by 34 publications

References 9 publications

Sound and Its Significance for Laboratory Animals

Sound and Its Significance for Laboratory Animals

EFFECT OF MORPHINE AND NALOXONE ON PRIMING‐INDUCED AUDIOGENIC SEIZURES IN BALB/c MICE

Noise and the young mouse: Genotype modifies the sensitive period for effects on cochlear physiology and audiogenic seizures.

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Sensitization for audiogenic seizures in two strains of mice and their F1 hybrids

Cited by 34 publications

References 9 publications

Sound and Its Significance for Laboratory Animals

Sound and Its Significance for Laboratory Animals

EFFECT OF MORPHINE AND NALOXONE ON PRIMING‐INDUCED AUDIOGENIC SEIZURES IN BALB/c MICE

Noise and the young mouse: Genotype modifies the sensitive period for effects on cochlear physiology and audiogenic seizures.

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Sensitization for audiogenic seizures in two strains of mice and their F₁ hybrids