Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models

Zhu, Xiaoyu; Guo, Dazhi; Lao, Qiao-Cong; Xu, Yiqiao; Meng, Zhao-Ke; Xia, Bo; Yang, Hua; Li, Chunqi; Li, Ping

doi:10.1038/s41598-019-40866-2

Cited by 30 publications

(19 citation statements)

References 55 publications

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“…Zebrafish models are also employed for technical advantages including the ease of advanced genetic studies, expression of tumor in any organ and the striking resemblance to human malignancies [171]. Zhu et al [172] used furanodiene which is a terpenoid isolated from Rhizoma curcumae, for their anticancer effects in zebrafish models. They observed that furanodiene showed anticancer effects in a pancreatic cell line (JF 305) and human breast cancer cells (MCF-7) transplanted into zebrafish.…”

Section: In Vivo Studies Of Anticancer Herbal Medicine: An Overviewmentioning

confidence: 99%

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Khan

Ali

Khan³

et al. 2019

Biomolecules

212

118

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The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal medicine provides a very feasible alternative to western medicine against cancer. This article reviews the selected plant species with active phytochemicals, the animal models used for these studies, and their regulatory aspects. This study is based on a meticulous literature review conducted through the search of relevant keywords in databases, Web of Science, Scopus, PubMed, and Google Scholar. Twenty plants were selected based on defined selection criteria for their potent anticancer compounds. The detailed analysis of the research studies revealed that plants play an indispensable role in fighting different cancers such as breast, stomach, oral, colon, lung, hepatic, cervical, and blood cancer cell lines. The in vitro studies showed cancer cell inhibition through DNA damage and activation of apoptosis-inducing enzymes by the secondary metabolites in the plant extracts. Studies that reported in vivo activities of these plants showed remarkable results in the inhibition of cancer in animal models. Further studies should be performed on exploring more plants, their active compounds, and the mechanism of anticancer actions for use as standard herbal medicine.

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Section: In Vivo Studies Of Anticancer Herbal Medicine: An Overviewmentioning

confidence: 99%

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Khan

Ali

Khan³

et al. 2019

Biomolecules

212

118

View full text Add to dashboard Cite

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“…There are several examples of such synergy. Furanodiene, a natural terpenoid isolated from Rhizoma curcumae , showed a markedly synergistic anticancer effect when used in combination with 5-fluorouracil [ 43 ]. Cucurbitacins have strong antiproliferative effects and can be promising candidates for combination therapy with clinically used anticancer agents [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

A Water-Soluble Antibiotic in Rhubarb Stalk Shows an Unusual Pattern of Multiple Zones of Inhibition and Preferentially Kills Slow-Growing Bacteria

2021

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Organic extract of Rhubarb (Rheum officinale) roots is known to have several medicinal uses. However, not much research has been done with the rhubarb stalk. The aim of this research is to evaluate the anti-bacterial and anti-proliferative effects of the aqueous extract from rhubarb stalks. The crude aqueous extract was further purified using anion exchange and gel filtration. The purified compound demonstrated broad spectrum antibacterial activity against the Gram-negative bacteria, E. coli and Aggregatibacter actinomycetemcomitans, and Gram-positive bacteria, S. aureus. A time-kill assay demonstrated that the antibiotic has strong bactericidal activity. It also has anti-proliferative action against the breast cancer cell line MCF-7 with no cytotoxicity, although the crude extract had a significant cytotoxic effect. The antibiotic activity, as measured by the diameter of the zone of inhibition, increased by several fold in low nutrient and/or low salt agar, suggesting that the antibiotic preferentially kills slow-growing bacteria. The antibiotic also gives an unusual pattern of multiple zones of inhibition in which several zones of cell growth are seen within the zone of inhibition. In conclusion, the active component in the aqueous extract of rhubarb stalk has great potential as a strong bactericidal antibiotic and as an anti-proliferative drug.

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“… [ 115 ] Breast cancer and Liver cancer Xenograft model Furanodiene showed a markedly synergistic anti-cancer effect when used in combination with 5-FU (5-Fluorouracil) for both human breast cancer MDA-MB-231 cells and human liver cancer BEL-7402 cells xenotransplanted into zebrafish. [ 68 ] Colon Cancer Xenograft model After NR1D1 gene is knocked out, the cell viability is impaired and the formation of micrometastasis is reduced. [ 116 ] Colorectal cancer Xenograft model Endoglin-expressing fibroblasts enhanced colorectal tumor cell infiltration into the liver and decreased survival.…”

Section: Zebrafish Modelmentioning

confidence: 99%

“…In this model, they found that GREM1 promotes fibrosis in breast cancer-associated fibroblast (CAF) and promotes intravasation and extravasation in breast cancer. Zhu et al 68 established a breast cancer xenotransplantation model in zebrafish and used Furanodiene and 5-FU (5-Fluorouracil) to treat zebrafish. Compared with the results of furadiene alone, the results showed that the two drugs had an obvious synergistic anticancer effect.…”

Section: Zebrafish Modelmentioning

confidence: 99%

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

Wen-ling

Wang

et al. 2021

CMAR

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Animal models refers to the animal experimental objects and related materials that can simulate human body established in medical research. As the second-largest disease in terms of morbidity and mortality after cardiovascular disease, cancer has always been the focus of human attention all over the world, which makes it a research hotspot in the medical field. At the same time, more and more animal models have been constructed and used in cancer research. With the deepening of research, the construction methods of cancer animal models are becoming more and more diverse, including chemical induction, xenotransplantation, gene programming, and so on. In recent years, patient-derived xenotransplantation (PDX) model has become a research hotspot because it can retain the microenvironment of the primary tumor and the basic characteristics of cells. Animal models can be used not only to study the biochemical and physiological processes of the occurrence and development of cancer in objects but also for the screening of cancer drugs and the exploration of gene therapy. In this paper, several main tumor animal models and the application progress of animal models in tumor research are systematically reviewed. Finally, combined with the latest progress and development trend in this field, the future research of tumor animal model was prospected.

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Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models

Cited by 30 publications

References 55 publications

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

Anticancer Plants: A Review of the Active Phytochemicals, Applications in Animal Models, and Regulatory Aspects

A Water-Soluble Antibiotic in Rhubarb Stalk Shows an Unusual Pattern of Multiple Zones of Inhibition and Preferentially Kills Slow-Growing Bacteria

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

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