Sensitization and individual differences to IP amphetamine, cocaine, or caffeine following repeated intracranial amphetamine infusions

Hooks, M.S.; Jones, G. H.; Liem, Ben; Justice, Joseph B.

doi:10.1016/0091-3057(92)90413-a

Cited by 102 publications

(62 citation statements)

References 30 publications

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“…Previous research has found that novelty-induced activity can serve as a predictive variable for a rat's sensitivity to the behavioral effects of abused drugs. This list of behaviors includes self-administration [14,15,29], drug discrimination [13], context conditioning [17], bar-press suppression [6], and locomotor activity [16,29]. Much of the research just cited reports a positive relation between reactivity to novelty and the subsequent behavioral effect of interest.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, rats that are more activated by exposure to a novel environment (HR) more readily self-administer amphetamine and are more sensitive to the locomotor-stimulant effects of amphetamine [29]. Novelty-induced activity has been found to also predict such behavioral effects as activity induced by cocaine and caffeine [16], ethanol-induced activity and ethanol self-administration [14,15], amphetamine-conditioned hyperactivity to contextual stimuli [17], cueing effects of amphetamine [13] and amphetamine barpress suppressant effects [6].Another factor contributing to the interest in novelty-induced activity is the potential insight it may provide into the behavioral and neural substrates underlying individual differences in drug abuse vulnerability. This idea is based, in part, on the assumption that the predictive relation just described likely refl ects an overlap in the mechanism(s) responsible Published in Physiology & Behavior 72 (2001) Abstract: An increasing body of research has focused on isolating factors that predict or alter individual differences in the behavioral and neural processes mediating the effects of abused drugs.…”

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confidence: 99%

“…Refs. [6,16,29]; see Section 1.4). To do so, we had rats that were repeatedly treated with ( -)-nicotinedi-D tartrate and an injection-matched saline control.…”

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confidence: 99%

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confidence: 99%

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Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors

Bevins¹,

Besheer²

2001

Physiology & Behavior

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Rats exposed to a small inescapable environment are more active when the environment is novel than when it is familiar (Refs. [23,33]; see later). Recently, the empirical and theoretical interest in the behavioral activating effect of novelty has increased. This interest is driven, in part, by evidence indicating that reactivity to a novel environment is a behavioral measure of a rat's sensitivity to stress. Rats exposed to a novel environment show an increase in plasma levels of the "stress hormone" corticosterone (e.g., Ref. [25]). Importantly, novelty-induced increases in corticosterone are greater in rats that display more locomotor activity to an inescapable novel environment [29]. Moreover, rats more activated by exposure to a novel environment [often termed high responders (FIR)] displayed a greater increase in corticosterone levels to restraint stress than rats that were less reactive to the novel environment [low responders (LR)]. HR also had a more prolonged increase in corticosterone to this restraint than LR [10]. This work is important because it demonstrates that a purported behavioral measure of stress sensitivity (i.e., novelty-induced activity) predicts the response to another form of stress (i.e., restraint).Reactivity to a novel environment has served as a predictive variable in recent drug abuse studies (see Refs. [9,31 ] for reviews). This predictive value is another reason for the recent interest in novelty-induced activity. For instance, rats that are more activated by exposure to a novel environment (HR) more readily self-administer amphetamine and are more sensitive to the locomotor-stimulant effects of amphetamine [29]. Novelty-induced activity has been found to also predict such behavioral effects as activity induced by cocaine and caffeine [16], ethanol-induced activity and ethanol self-administration [14,15], amphetamine-conditioned hyperactivity to contextual stimuli [17], cueing effects of amphetamine [13] and amphetamine barpress suppressant effects [6].Another factor contributing to the interest in novelty-induced activity is the potential insight it may provide into the behavioral and neural substrates underlying individual differences in drug abuse vulnerability. This idea is based, in part, on the assumption that the predictive relation just described likely refl ects an overlap in the mechanism(s) responsible Published in Physiology & Behavior 72 (2001) Abstract: An increasing body of research has focused on isolating factors that predict or alter individual differences in the behavioral and neural processes mediating the effects of abused drugs. Within this framework, the current report assessed individual differences and the locomotor effect of nicotine. Rats were screened for activity induced by a novel environment. Rats, which were more active to initial environment exposure, remained more active even after seven additional 30-min exposures to the same environment. Treatment with nicotine-di-D tartrate (1 mg/kg, sc) disrupted this effect. This nicotine disruption of indiv...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…Refs. [6,16,29]; see Section 1.4). To do so, we had rats that were repeatedly treated with ( -)-nicotinedi-D tartrate and an injection-matched saline control.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors

Bevins¹,

Besheer²

2001

Physiology & Behavior

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“…A number of studies have now shown that repeated exposure to systemic AMPH leads to augmentations in the locomotor and NAcc DA responses to AMPH (Vanderschuren and Kalivas, 2000), the locomotor activating effects of cocaine (Schenk et al, 1991;Hooks et al, 1992) as well as enhanced self-administration of AMPH (Piazza et al, 1989;Pierre and Vezina, 1997;Mendrek et al, 1998;Lorrain et al, 2000) and cocaine (Horger et al, 1992;Valadez and Schenk, 1994). AMPH appears to produce these long-lasting effects by acting in the VTA.…”

Section: Amph Acts In the Vta To Induce Psychostimulant Sensitizationmentioning

confidence: 99%

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Suto

Tanabe

Austin

et al. 2003

Neuropsychopharmacol

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Previous exposure to amphetamine (AMPH) in the ventral tegmental area (VTA) enhances cocaine self-administration in a D 1 dopamine receptor-dependent manner. The present study examined the contribution of VTA NMDA, AMPA/kainate, and metabotropic glutamate (mGlu) receptors to this effect. Rats in different groups received three intra-VTA injections, one every third day, of either saline (0.5 ml/ side), AMPH (2.5 mg/0.5 ml/side), AMPH+CPP (NMDA receptor antagonist; 10 mM or 100 mM/0.5 ml/side), AMPH+CNQX (AMPA/ kainate receptor antagonist; 0.3 mM or 1 mM/0.5 ml/side), AMPH+MCPG (mGlu receptor antagonist; 0.5 mM or 50 mM/0.5 ml/side), or the glutamate receptor antagonists alone. Starting 7-10 days after the last pre-exposure injection, rats were trained to self-administer cocaine (0.3 mg/kg/infusion) and then tested under a progressive ratio (PR) schedule of reinforcement for 6 consecutive days. As reported previously, VTA AMPH pre-exposed rats worked more and obtained more infusions of cocaine than saline pre-exposed animals. Coadministration of CPP, CNQX, or MCPG with AMPH during pre-exposure dose-dependently blocked this enhancement of cocaine self-administration. Rats pre-exposed to the glutamate receptor antagonists alone did not differ on the test days from the saline pre-exposed controls. These results indicate that, in a manner paralleling the induction of sensitization of the locomotor stimulating effects of AMPH, activation of NMDA, AMPA/kainate, and mGlu receptors during pre-exposure to AMPH in the VTA is necessary for the enhancement of cocaine self-administration to develop.

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Effects of SCH-23390 on dopamine D1 receptor occupancy and locomotion produced by intraaccumbens cocaine infusion

Neisewander

Fuchs

O’Dell

et al. 1998

Synapse

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This study examined the effects of both systemic and intraaccumbens administration of SCH-23390 in rats on dopamine D1 receptor occupancy and on locomotor activity produced by intraaccumbens infusion of cocaine. In experiment 1, rats received SCH-23390 (0-1 mg/kg, i.p.) 15 minutes prior to intraaccumbens infusion of cocaine (0 or 100 microg/side). In experiment 2, rats received coinfusion of SCH-23390 (0-1 microg/side) and cocaine (0 or 100 microg/side) into the nucleus accumbens (NAc). After behavioral testing, receptors occupied by SCH-23390 were quantified by injecting animals with their respective dose of SCH-23390, followed by a systemic injection of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Receptors occupied by SCH-23390, and therefore protected from EEDQ-induced inactivation, were quantified from autoradiograms of sections labeled with 3H-SCH-23390. Systemic administration of SCH-23390 dose-dependently (0.1-1.0 mg/kg) reversed cocaine-induced locomotion and occupied 72-100% of D1-like receptors in the anterior NAc. D1 receptor occupancy following systemic administration of SCH-23390 was evident as an inverted U-shaped, dose-dependent change, with the greatest occupancy observed at the intermediate dose of 0.3 mg/kg. Intraaccumbens infusion of SCH-23390 did not alter cocaine-induced locomotor activity despite occupying 40-60% of D1-like receptors in the anterior NAc core and shell. The findings that systemic, but not intraaccumbens, administration of SCH-23390 potently reversed locomotion produced by intraaccumbens cocaine infusion suggest that stimulation of D1 receptors in regions other than the NAc is involved in locomotion produced by intraaccumbens infusion of cocaine, and that stimulation of D1 receptors in the NAc is not necessary for this behavior.

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Sensitization and individual differences to IP amphetamine, cocaine, or caffeine following repeated intracranial amphetamine infusions

Cited by 102 publications

References 30 publications

Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors

Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Effects of SCH-23390 on dopamine D1 receptor occupancy and locomotion produced by intraaccumbens cocaine infusion

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