Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI)

McInturff, Stephen; Adenis, Victor; Coen, Florent-Valéry; Lacour, Stéphanie; Lee, Daniel J; Brown, M. Christian

doi:10.1007/s10162-023-00897-z

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…LCIC is a multimodal convergence zone ( Robards, 1979 ; Bácskai et al, 2002 ; Dillingham et al, 2017 ; Liu et al, 2023 ) with physiological response properties that seem to deal more with the physical context of sound ( Aitkin et al, 1978 ). The different CN projections to the IC have a practical implication: the effectiveness of auditory brainstem implants in the CN as reflected by IC responses favors the VCN over the DCN as the preferred target for stimulation ( McInturff et al, 2022 , 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Differential projections from the cochlear nucleus to the inferior colliculus in the mouse

Ryugo

Milinkeviciute

2023

Front. Neural Circuits

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The cochlear nucleus (CN) is often regarded as the gateway to the central auditory system because it initiates all ascending pathways. The CN consists of dorsal and ventral divisions (DCN and VCN, respectively), and whereas the DCN functions in the analysis of spectral cues, circuitry in VCN is part of the pathway focused on processing binaural information necessary for sound localization in horizontal plane. Both structures project to the inferior colliculus (IC), which serves as a hub for the auditory system because pathways ascending to the forebrain and descending from the cerebral cortex converge there to integrate auditory, motor, and other sensory information. DCN and VCN terminations in the IC are thought to overlap but given the differences in VCN and DCN architecture, neuronal properties, and functions in behavior, we aimed to investigate the pattern of CN connections in the IC in more detail. This study used electrophysiological recordings to establish the frequency sensitivity at the site of the anterograde dye injection for the VCN and DCN of the CBA/CaH mouse. We examined their contralateral projections that terminate in the IC. The VCN projections form a topographic sheet in the central nucleus (CNIC). The DCN projections form a tripartite set of laminar sheets; the lamina in the CNIC extends into the dorsal cortex (DC), whereas the sheets to the lateral cortex (LC) and ventrolateral cortex (VLC) are obliquely angled away. These fields in the IC are topographic with low frequencies situated dorsally and progressively higher frequencies lying more ventrally and/or laterally; the laminae nestle into the underlying higher frequency fields. The DCN projections are complementary to the somatosensory modules of layer II of the LC but both auditory and spinal trigeminal terminations converge in the VLC. While there remains much to be learned about these circuits, these new data on auditory circuits can be considered in the context of multimodal networks that facilitate auditory stream segregation, signal processing, and species survival.

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Section: Discussionmentioning

confidence: 99%

Differential projections from the cochlear nucleus to the inferior colliculus in the mouse

Ryugo

Milinkeviciute

2023

Front. Neural Circuits

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“…Thus, electrical approaches have been developed to stimulate central circuits of the auditory pathway to restore auditory perception in humans ( Colletti et al, 2009 ; Lim and Lenarz, 2015 ). One solution is the electrical stimulation of the cochlear nucleus (CN) via an auditory brainstem implant (ABI), which consists of either an electrode surface array (e.g., McInturff et al, 2023 ) or penetrating array (PABI, e.g., McCreery et al, 2018 ). Although the PABI provides lower thresholds and a greater selectivity ( Shannon, 2012 ), no difference in speech understanding could be observed between patients with PABIs or surface arrays ( Otto et al, 2008 ; Wong et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Differential optogenetic activation of the auditory midbrain in freely moving behaving mice

Rogalla,

Seibert,

Sleeboom

et al. 2023

Front. Syst. Neurosci.

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IntroductionIn patients with severe auditory impairment, partial hearing restoration can be achieved by sensory prostheses for the electrical stimulation of the central nervous system. However, these state-of-the-art approaches suffer from limited spectral resolution: electrical field spread depends on the impedance of the surrounding medium, impeding spatially focused electrical stimulation in neural tissue. To overcome these limitations, optogenetic activation could be applied in such prostheses to achieve enhanced resolution through precise and differential stimulation of nearby neuronal ensembles. Previous experiments have provided a first proof for behavioral detectability of optogenetic activation in the rodent auditory system, but little is known about the generation of complex and behaviorally relevant sensory patterns involving differential activation.MethodsIn this study, we developed and behaviorally tested an optogenetic implant to excite two spatially separated points along the tonotopy of the murine inferior colliculus (ICc).ResultsUsing a reward based operant Go/No-Go paradigm, we show that differential optogenetic activation of a sub-cortical sensory pathway is possible and efficient. We demonstrate how animals which were previously trained in a frequency discrimination paradigm (a) rapidly respond to either sound or optogenetic stimulation, (b) generally detect optogenetic stimulation of two different neuronal ensembles, and (c) discriminate between them.DiscussionOur results demonstrate that optogenetic excitatory stimulation at different points of the ICc tonotopy elicits a stable response behavior over time periods of several months. With this study, we provide the first proof of principle for sub-cortical differential stimulation of sensory systems using complex artificial cues in freely moving animals.

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Sensitivity to Pulse Rate and Amplitude Modulation in an Animal Model of the Auditory Brainstem Implant (ABI)

Cited by 2 publications

References 56 publications

Differential projections from the cochlear nucleus to the inferior colliculus in the mouse

Differential projections from the cochlear nucleus to the inferior colliculus in the mouse

Differential optogenetic activation of the auditory midbrain in freely moving behaving mice

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