Sensitivity to Mivacurium in a Patient with Mitochondrial Myopathy

Naguib, Mohamed; Dawlatly, Abdel Azim El; Ashour, Mahmoud; Al-Bunyan, Muneera A.

doi:10.1097/00000542-199606000-00029

Cited by 33 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…140 Subclinical erosion of hepatorenal reserve may alter clinical pharmacokinetics for intravenous drugs and predispose to delayed recovery from anesthetic agents, muscle relaxants, and opioids. There is a case report that describes increased sensitivity to nondepolarizing blockade in a patient with mitochondrial myopathy, 142 but this observation has not been confirmed for most forms of inherited mitochondrial cytopathy. There is a case report that describes increased sensitivity to nondepolarizing blockade in a patient with mitochondrial myopathy, 142 but this observation has not been confirmed for most forms of inherited mitochondrial cytopathy.…”

Section: Patients With Mitochondrial Cytopathymentioning

confidence: 98%

Clinical Implications of Mitochondrial Dysfunction

Muravchick

Levy

2006

Anesthesiology

View full text Add to dashboard Cite

Mitochondria produce metabolic energy, serve as biosensors for oxidative stress, and eventually become effector organelles for cell death through apoptosis. The extent to which these manifold mitochondrial functions are altered by previously unrecognized actions of anesthetic agents seems to explain and link a wide variety of perioperative phenomena that are currently of interest to anesthesiologists from both a clinical and a scientific perspective. In addition, many surgical patients may be at increased perioperative risk because of inherited or acquired mitochondrial dysfunction leading to increased oxidative stress. This review summarizes the essential aspects of the bioenergetic process, presents current knowledge regarding the effects of anesthetics on mitochondrial function and the extent to which mitochondrial state determines anesthetic requirement and potential anesthetic toxicity, and considers some of the many implications that our knowledge of mitochondrial dysfunction poses for anesthetic management and perioperative medicine.

show abstract

Section: Patients With Mitochondrial Cytopathymentioning

confidence: 98%

Clinical Implications of Mitochondrial Dysfunction

Muravchick

Levy

2006

Anesthesiology

View full text Add to dashboard Cite

show abstract

“…Infants with complex I and IV respiratory chain deficiencies may present with lactic acidosis (potentially life‐threatening), hypoglycaemia, diffuse hypotonia, apnoeic episodes, hypertrophic cardiomyopathy and/or hepatic dysfunction (8). Malignant hyperthermia has been associated with mitochondrial myopathies (9,10) and increased sensitivity to nondepolarizing muscle relaxants has been reported (11,12).…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic considerations for a child with combined Prader–Willi syndrome and mitochondrial myopathy

Sharma

Erb

Schulman

et al. 2001

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

“…Respiratory function is often poor before surgery and patients will be at higher risk of postoperative respiratory complications [11]. Patients with mitochondrial myopathies have also previously been reported as being sensitive to nondepolarizing neuromuscular blocking drugs [14,15]. Malignant hyperpyrexia (MH) is a risk, with one case reported [12], although there are other case reports in which volatiles were used without triggering MH [13].…”

Section: Discussionmentioning

confidence: 99%