Sensitivity to change of composite and frequency scores of the neuropsychiatric inventory in mild cognitive impairment

Cummings, Jeffrey L.; Tribanek, Michael; Hoerr, Robert

doi:10.1017/s1041610214001185

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Cognitive function was evaluated using several measures . Episodic memory was evaluated with the composite score of immediate recall and delayed recall.…”

Section: Methodsmentioning

confidence: 99%

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Neighborhood‐based social capital and cognitive function among older adults in five low‐ and middle‐income countries: Evidence from the World Health Organization Study on global AGEing and adult health

Jiang

Lü

et al. 2019

Int J Geriat Psychiatry

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Objectives This study aims to investigate which neighborhood‐based social capital components are associated with a higher level of cognitive function in LMICs. Methods This international population‐based study used cross‐sectional survey data from the World Health Organization's Study on global AGEing and adult health (SAGE), a study of adults aged 50 years or older in China, Ghana, India, the Russian Federation, and South Africa from 2007 through 2010 (N = 29 528). Associations between neighborhood‐based social capital indicators (trust in neighbors, perceived neighborhood safety, and community participation) and cognitive function were examined using ordinary least squares regressions and random‐effects meta‐analyses. Results Results of the meta‐analyses of within‐country effects indicated that trust in neighbors were positively associated with cognitive function across India, Russia, and Ghana, but negatively associated in South Africa (β = −0.041, SE = .013, P < .01) and no effect in China (P > .05). The significant effect of perceived neighborhood safety was only found in South Africa (β = 0.051, SE = .007, P < .001) and China (β = 0.030, SE = .005, P < .001). Community participation approached a null effect in South Africa (P > .05). Discussion Different indicators of neighborhood‐based social capital, which are well‐established protective resources for cognitive function, may have varied relationships with cognitive function cross‐nationally. This finding provides a better understanding of the mechanisms by which neighborhood social capital may contribute to better cognitive function in LMICs than high‐income countries, potentially due to differences in neighborhood environments, health systems, and availability of public resources.

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“…Cognitive function was evaluated using several measures . Episodic memory was evaluated with the composite score of immediate recall and delayed recall.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive function was evaluated using several measures. [34][35][36] Episodic memory was evaluated with the composite score of immediate recall and delayed recall. For the immediate word recall, the participants were asked to repeat 10 unrelated words and had to immediately recall as many words as they could.…”

Section: Outcome: Cognitive Functionmentioning

confidence: 99%

Neighborhood‐based social capital and cognitive function among older adults in five low‐ and middle‐income countries: Evidence from the World Health Organization Study on global AGEing and adult health

Jiang

Lü

et al. 2019

Int J Geriat Psychiatry

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“…The 15-item Geriatric Depression Scale [GDS-15, 27] is a screening tool with higher overall total scores (range 0–15) indicating higher depression levels, and studies have reported evidence of concurrent validity [28–30] and diagnostic accuracy [30, 31]. The Neuropsychiatric Inventory [NPI, 32] is an assessment tool for frequency and severity of behavioural and psychological symptoms in dementia with higher overall scores (range 0–144) indicating poorer health, and studies have reported evidence of sensitivity to treatment-related changes [33, 34]. The Bristol Activities of Daily Living Scale [BADL, 35] is an assessment tool for functional decline among people with dementia in terms of their ability to carry out daily living activities independently with higher overall total scores (range 0–60) indicating more dependence, and studies have reported convergent validity and sensitivity to treatment-related changes [36, 37].…”

Section: Methodsmentioning

confidence: 99%

Quality-of-life assessment in dementia: the use of DEMQOL and DEMQOL-Proxy total scores

et al. 2016

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PurposeThere is a need to determine whether health-related quality-of-life (HRQL) assessments in dementia capture what is important, to form a coherent basis for guiding research and clinical and policy decisions. This study investigated structural validity of HRQL assessments made using the DEMQOL system, with particular interest in studying domains that might be central to HRQL, and the external validity of these HRQL measurements.MethodsHRQL of people with dementia was evaluated by 868 self-reports (DEMQOL) and 909 proxy reports (DEMQOL-Proxy) at a community memory service. Exploratory and confirmatory factor analyses (EFA and CFA) were conducted using bifactor models to investigate domains that might be central to general HRQL. Reliability of the general and specific factors measured by the bifactor models was examined using omega (ω) and omega hierarchical (ω h) coefficients. Multiple-indicators multiple-causes models were used to explore the external validity of these HRQL measurements in terms of their associations with other clinical assessments.ResultsBifactor models showed adequate goodness of fit, supporting HRQL in dementia as a general construct that underlies a diverse range of health indicators. At the same time, additional factors were necessary to explain residual covariation of items within specific health domains identified from the literature. Based on these models, DEMQOL and DEMQOL-Proxy overall total scores showed excellent reliability (ω h > 0.8). After accounting for common variance due to a general factor, subscale scores were less reliable (ω h < 0.7) for informing on individual differences in specific HRQL domains. Depression was more strongly associated with general HRQL based on DEMQOL than on DEMQOL-Proxy (−0.55 vs −0.22). Cognitive impairment had no reliable association with general HRQL based on DEMQOL or DEMQOL-Proxy.ConclusionsThe tenability of a bifactor model of HRQL in dementia suggests that it is possible to retain theoretical focus on the assessment of a general phenomenon, while exploring variation in specific HRQL domains for insights on what may lie at the ‘heart’ of HRQL for people with dementia. These data suggest that DEMQOL and DEMQOL-Proxy total scores are likely to be accurate measures of individual differences in HRQL, but that subscale scores should not be used. No specific domain was solely responsible for general HRQL at dementia diagnosis. Better HRQL was moderately associated with less depressive symptoms, but this was less apparent based on informant reports. HRQL was not associated with severity of cognitive impairment.Electronic supplementary materialThe online version of this article (doi:10.1007/s11136-016-1343-1) contains supplementary material, which is available to authorized users.

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“…M ood a n d b e h av i o r a l r i s k fac to r s The Spanish validated version of the Cornell Scale for Depression in Dementia (CSDD) (Pujol et al, 2001;Towsley et al, 2012) was used to assess signs and symptoms of major depression. The validated Spanish version of the Neuropsychiatric Inventory (NPI) (Boada et al, 2005;Cummings et al, 2014) was employed to evaluate the frequency and severity of neuropsychiatric disturbances.…”

Section: Fallsmentioning

confidence: 99%

Influence of cognitive impairment on fall risk among elderly nursing home residents

Seijo-Martínez

Cancela

Varela

et al. 2016

Int. Psychogeriatr.

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Sensitivity to change of composite and frequency scores of the neuropsychiatric inventory in mild cognitive impairment

Abstract: Our findings support the hypothesis that in MCI, as in dementia, the NPI frequency score is not more sensitive to treatment-related change than the composite score. As the severity score adds information, the use of the composite score has better performance characteristics.

Cited by 4 publications

References 18 publications

Neighborhood‐based social capital and cognitive function among older adults in five low‐ and middle‐income countries: Evidence from the World Health Organization Study on global AGEing and adult health

Neighborhood‐based social capital and cognitive function among older adults in five low‐ and middle‐income countries: Evidence from the World Health Organization Study on global AGEing and adult health

Quality-of-life assessment in dementia: the use of DEMQOL and DEMQOL-Proxy total scores

Influence of cognitive impairment on fall risk among elderly nursing home residents

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