“…Although there have been significant research efforts concerning the fundamental characteristics of IALRs under ambient conditions (Heijnen et al, 1997;Huang et al, 2007Huang et al, , 2008Lin et al, 1997aLin et al, , 1997bMudde and Van den Akker, 2001;Talvy et al, 2007aTalvy et al, , 2007b, the scale effect on the flow structure is still not fully understood. Sound understanding of the hydrodynamic behavior in IALRs (e.g., flow regime, phase holdup, bubble characteristics, interfacial phenomenon, backmixing, and interphase transport) is therefore essential in designing and scaling up these slurry reactors, especially under the condition of elevated pressure and high temperature with relevance to industrial reactive processes.…”