Sensitivity of the amplitude of the single muscle fibre action potential to microscopic volume conduction parameters

Albers, B.A.; Rutten, Wim; Jonge, W. Wallinga-de; Boom, H.B.K.

doi:10.1007/bf02447499

Cited by 12 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neglecting some side effects (the frequency-dependence of some volume conduction parameters [17]- [18] or the distortion of the electric field introduced by the recording electrode [8]), we can assume that the amplitude of a SFAP is lower as the radial distance increases. In contrast, duration parameters of the SFAP main spike (i.e.…”

Section: Msd -Radial Distance Correlationmentioning

confidence: 99%

Modelling Fibrillation Potentials—Analysis of Time Parameters in the Muscle Intracellular Action Potential

Rodriguez‐Falces

Trigueros²,

Useros³

et al. 2007

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

A single fiber action potential (SFAP) can be modelled as the convolution of a biolectrical source and a filter impulse response. In the Dimitrov-Dimitrova (D-D) convolutional model, the first temporal derivative of the intracellular action potential (IAP) is used as the source, and Tspl is a time parameter related to the duration of the IAP waveform. This paper is centred on the relation between Tspl and the main spike duration (MSD), defined as the time interval between the first and third phases of the SFAP. We show that Tspl essentially determines the MSD parameter. As experimental data, we used fibrillation potentials (FPs) of two different muscles to study the D-D model. We found that Tspl should have a certain statistical variability in order to explain the variability in the MSD of our FPs. In addition, we present a method to estimate the Tspl values corresponding to a given SFAP from its measured MSD.

show abstract

Section: Msd -Radial Distance Correlationmentioning

confidence: 99%

Modelling Fibrillation Potentials—Analysis of Time Parameters in the Muscle Intracellular Action Potential

Rodriguez‐Falces

Trigueros²,

Useros³

et al. 2007

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…Close to the active fiber, the frequency-dependent behavior of the muscle fiber membranes has to be taken into account. Microscopic, frequency-dependent volume conduction parameters in skeletal muscle tissue can be introduced in an electrical network model (7,8). Such a network model has been used to calculate SFAPs (7)(8)(9)14), and its results (9,14) have been related to experimental results ( 15,16).…”

Section: Introductionmentioning

confidence: 99%

“…Several attempts have been made to explain the discrepancies between experimental and simulation results by volume conduction effects. Attention was paid to (a) sensitivity to changes in the network parameters (8), (b) capacitive properties of the T-tubular system (7), (c) frequency-dependent properties of the outer medium surrounding the core network part of the model ( 9), (d) muscle boundary ( 14), and (e) the presence of inhomogeneities (not yet published). However, no apparently improving effect was found either on the duration or on the shape of the computed SFAPs.…”

Section: Introductionmentioning

confidence: 99%

“…In an approximating description, the current can be represented by a current tripole along the fiber axis ( 17,18). Alternatively, the shape of the intracellular action potential (IAP) can be approximated by a synthetic Gaussian curve ( 19) or a quasicontinuous function (6)(7)(8)(9)14). The transmembrane current is then calculated as the second derivative of the IAP.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The bioelectrical source in computing single muscle fiber action potentials

Veen

Wolters

Wallinga

et al. 1993

Biophysical Journal

View full text Add to dashboard Cite

Generally, single muscle fiber action potentials (SFAPs) are modeled as a convolution of the bioelectrical source (being the transmembrane current) with a weighting or transfer function, representing the electrical volume conduction. In practice, the intracellular action potential (IAP) rather than the transmembrane current is often used as the source, because the IAP is relatively easy to obtain under experimental conditions. Using a core conductor assumption, the transmembrane current equals the second derivative of the IAP. In previous articles, discrepancies were found between experimental and simulated SFAPs. Adaptations in the volume conductor slightly altered the simulation results. Another origin of discrepancy might be an erroneous description of the source. Therefore, in the present article, different sources were studied. First, an analytical description of the IAP was used. Furthermore, an experimental IAP, a special experimental SFAP, and a measured transmembrane current scaled to our experimental situation were applied. The results for the experimental IAP were comparable to those with the analytical IAP. The best agreement between experimental and simulated data was found for a measured transmembrane current as source, but differences are still apparent.

show abstract

“…The experimental observations are indicated by the symbols given in Table I. Examples of simulations are represented by the curves (background see Albers et al 1988c) along the muscle fibre was determined as well. If there was any variation of the conduction velocity during a train of responses, it remained very small.…”

Section: It Is Generally Assumed That Vtt Decreases Andmentioning

confidence: 99%

Quantitative analysis of single muscle fibre action potentials recorded at known distances

Albers

Put

Wallinga

et al. 1989

Electroencephalography and Clinical Neurophysiology

View full text Add to dashboard Cite

In vivo records of single fibre action potentials (SFAPs) have always been obtained at unknown distance from the active muscle fibre. A new experimental method has been developed enabling the derivation of the recording distance in animal experiments. A single fibre is stimulated with an intracellular micropipette electrode. The same electrode is used thereafter for labelling with an auto-fluorescent dye, Lucifer Yellow. In this method there is no use of chemical fixation. The tissue structure is kept as well as possible. In cross-sections the fluorescent fibre is seen and its position is quantitized with respect to the tip of one or more recording wire electrodes. Morphometric data, such as the recording distance and the fibre cross-sectional area, are used for the interpretation of parameters of the SFAPs (peak-peak amplitude, time between the first positive and negative peaks). The present results show that within 300 microns recording distance is not as dominant for the SFAP shape as expected. The method offers also a direct check of the relation between the muscle fibre; diameter and the conduction velocity of the action potential. In the present small set of data there is no simple linear relationship.

show abstract

Sensitivity of the amplitude of the single muscle fibre action potential to microscopic volume conduction parameters

Cited by 12 publications

References 15 publications

Modelling Fibrillation Potentials—Analysis of Time Parameters in the Muscle Intracellular Action Potential

Modelling Fibrillation Potentials—Analysis of Time Parameters in the Muscle Intracellular Action Potential

The bioelectrical source in computing single muscle fiber action potentials

Quantitative analysis of single muscle fibre action potentials recorded at known distances

Contact Info

Product

Resources

About