Abstract:Background] The acute atrioventricular block (AAVB) rabbit has been known as a novel model for detecting druginduced Torsade de Pointes (TdP) arrhythmias with high specificity for proarrhythmic drugs. In this study, we assess sensitivity of the model to detect the drug-induced TdP by comparing proarrhythmic effects of dofetilide, a representative torsadogenic drug, on the AAVB rabbit with those on the methoxamine-sensitized rabbit, the firstly established proarrhythmia model.[Methods] All experiments were perf… Show more
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