Sensitivity of Staphylococcus Pyogenes to Benzylpenicillin and BRL 1241

Changes in Sensitivity of Staphylococci to Methicillin

“…Reports from a variety of sources (Garrod, 1960;Branch et al, 1960) have confirmed the preliminary findings of Knox (1960), Thompson et al (1960), and Stewart (1960a) that the sodium salt of methicillin (BRL 1241; " celbenin "; " staphcillin ") is uniformly active against Staphylococcus aureus, irrespectively of the resistance of this organism to penicillin G. Resistance to methicillin can, however, be produced artificially in vitro (Rolinson et al, 1960;Stewart, 1960a;Barber, 1960), and it is obvious that the usefulness of the drug will be governed largely by the prevalence of comparable resistance in vivO.…”

“…With the reservation quoted above, there is ample evidence that all typical strains of Staph. aureus are fully sensitive to methicillin, irrespectively of any resistance which they might possess to penicillin G (Thompson et al, 1960;Rolinson et al, 1960;Stewart, 1960a;Garrod, 1960;Jevons, 1961). The strains of Staph.…”

“…Since this paper was submitted letters from Jevons (1961), Rolinson (1961), andKnox (1961) Thompson et al, 1960;Rolinson et al, 1960;Stewart, 1960a;Garrod, 1960;Jevons, 1961). The strains of Staph.…”

Changes in antibiotic sensitivity in strains of Staphylococcus aureus, 1952-78.

“…This result approximates to the incidence of penicillin resistance found in strains isolated from inpatients. 7 to erythromycin, clindamycin, and sodium fusidate. Most of the strains were resistant only to one antibiotic, 12 5% were resistant to two drugs, and only one strain was resistant to more than three antibiotics.…”

Fatores de risco associados à colonização nasal por <i>Staphylococcus aureus</i> em pessoas vivendo com HIV/aids: um estudo caso-controle

“…A resistência dos microrganismos aos antimicrobianos é observada desde a introdução destes fármacos para uso clínico e aponta para uma tendência crescente do padrão de resistência do Staphylococcus aureus no mundo todo, principalmente à meticilina, como sinalizam os dados do SENTRY, um programa de vigilância antimicrobiana multicêntrico que monitorou infecções adquiridas no hospital e na comunidade (PFALLER et al, 1998;SADER et al, 2001;BIEDENBACH;MOET;JONES, 2004;SADER et al, 2004;MOET et al, 2007 (FLEMING, 1929;ABRAHAM;BARBER, 1948b;FORBES, 1949 HOLT, 1960;DOUTHWAITE;TRAFFORD, 1960;WHITBY;HARDING, 1960a;SIMON, 1960b).…”