Abstract:To study the relationship between aging and levels of monoaminergic neurons, 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of monoamine synthesis, was intraperitoneally administered to senescence-accelerated mouse-prone (SAMP8) mice. Time course of immunoreactive intensity for serotonergic (5-HT) neurons in the dorsal raphe nucleus, which were stained using laboratoryraised serotonin-specific antibody, was quantitatively evaluated using an image analysis system. Results showed that 5-HT neurons are not … Show more
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