Sensitivity of<i>Candida albicans</i>to essential oils: are they an alternative to antifungal agents?

Bona, Elisa; Cantamessa, Simone; Pavan, Matteo; Novello, Giorgia; Massa, Nadia; Rocchetti, Andrea; Berta, Graziella; Gamalero, Elisa

doi:10.1111/jam.13282

Cited by 94 publications

(71 citation statements)

References 62 publications

(65 reference statements)

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“…The sensitivity to the Mentha EOs was species and strain dependent, as can be seen for the different behavior of the two strains of C. albicans, with respect to the effect of M. pulegium and M. requenii. These results are in agreement with those of Bona et al [39] , who found that mint has a more efficient anti-Candida action than clotrimazole. Finally, M. aquatica did not show any inhibitory effect against the Candida spp.…”

Section: Resultssupporting

confidence: 93%

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

Fancello

Zara

Petretto

et al. 2017

International Journal of Food Properties

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The chemical composition, antimicrobial activity, and antioxidant activity of Mentha (M.) requienii, M. pulegium L., and M. aquatica (L.) Huds from Sardinia, Italy, were tested. The chemical composition was determined by Gas Chromatography-Mass Spectrometry (GC-MS) and GC-Flame Ionization Detector (GC-FID) analyses. The antiradical activity was assessed by 2,2-Diphenyl-1-picrylhydrazyl and antioxidant capacity assay (ABTS) assay and minimal inhibition concentration was determined by microdilution broth analysis. The major components found in M. requienii EO were pulegone, menthone, and limonene; similarly, the major components of M. pulegium EO were pulegone and iso-menthone. By contrast, the major components of the essential oil (EO) from M. aquatica are terpinyl acetate and eucalyptol. The antioxidant activity of M. aquatica EO was higher than that of M. requienii and M. pulegium. The EO from M. requienii had good antifungal and antioxidant activities. In the concentration range tested, the mint EOs did not show any antibacterial activity against Staphylococcus aureus 20231 Deutsche SammLung von Mikroorganismen und Zellkulturen (DSMZ), Salmonella enterica subsp. bongori serovar 66:z41:-13772 DSMZ, and four strains of Listeria monocytogenes. Lactic acid bacteria (LAB) strains were not inhibited by the EOs tested, with the exception of Lactobacillus brevis, which showed slight sensitivity to M. pulegium and M. requenii EOs. Yeast strains were in general sensitive to the different Mentha EOs tested and were species and strain dependent.

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Section: Resultssupporting

confidence: 93%

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

Fancello

Zara

Petretto

et al. 2017

International Journal of Food Properties

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“…In a study of 2016, 12 EOs (oregano and rosemary among the others) were tested against 30 different vaginal isolated strains of C. albicans and the results compared with those of three main used drugs (clotrimazole, fluconazole and itraconazole). [301] Results show that oregano essential oils inhibited both the growth and the activity of C. albicans more efficiently than clotrimazole and damages induced by essential oils at the cellular level were stronger than those caused by the reference drug. Lavandula binadulensis EO alone or in combination with Cuminum cyminum EO shows an interesting antifungal activity against 20 clinical isolates from patients with recurrent vulvovaginal candidiasis, [302] while in another study L. angustifolia EO show a similar behavior against 80 clinical isolates with an additional antibiofilm activity against one of them.…”

Section: Antimicrobial Activitymentioning

confidence: 93%

“…C. albicans is an important opportunistic pathogen, responsible for most yeast infections in humans. In a study of 2016, 12 EOs (oregano and rosemary among the others) were tested against 30 different vaginal isolated strains of C. albicans and the results compared with those of three main used drugs (clotrimazole, fluconazole and itraconazole) . Results show that oregano essential oils inhibited both the growth and the activity of C. albicans more efficiently than clotrimazole and damages induced by essential oils at the cellular level were stronger than those caused by the reference drug.…”

Section: Essential Oils: Very Old ‘Guys’ With Great Prospectsmentioning

confidence: 99%

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Napoli

Siracusa

Ruberto

2020

Chemistry & Biodiversity

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Lamiaceae is one of the largest families of flowering plants comprising about 250 genera and over 7,000 species. Most of the plants of this family are aromatic and therefore important source of essential oils. Lamiaceae are widely used as culinary herbs and reported as medicinal plants in several folk traditions. In the Mediterranean area oregano, sage, rosemary, thyme and lavender stand out for geographical diffusion and variety of uses. The aim of this review is to provide recent data dealing with the phytochemical and pharmacological studies, and the more recent applications of the essential oils and the non‐volatile phytocomplexes. This literature survey suggests how the deeper understanding of biomolecular processes in the health and food sectors as per as pest control bioremediation of cultural heritage, or interaction with human microbiome, fields, leads to the rediscovery and new potential applications of well‐known plants.

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“…Its activity and its derivatives, such as caryophyllene oxide is well known [134][135][136]. According to Bona et al [137], essential oils containing high concentrations of phenolic monoterpenes (e.g., carvacrol, p-cymene, thymol) have great antifungal activities. Rich in these substances are, among others Origanum and Thymus plants.…”

Section: Essential Oil Main Chemical Componentsmentioning

confidence: 99%

Essential Oils of Lamiaceae Family Plants as Antifungals

Karpiński

2020

Biomolecules

125

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The incidence of fungal infections has been steadily increasing in recent years. Systemic mycoses are characterized by the highest mortality. At the same time, the frequency of infections caused by drug-resistant strains and new pathogens e.g., Candida auris increases. An alternative to medicines may be essential oils, which can have a broad antimicrobial spectrum. Rich in the essential oils are plants from the Lamiaceae family. In this review are presented antifungal activities of essential oils from 72 Lamiaceae plants. More than half of these have good activity (minimum inhibitory concentrations (MICs) < 1000 µg/mL) against fungi. The best activity (MICs < 100) have essential oils from some species of the genera Clinopodium, Lavandula, Mentha, Thymbra, and Thymus. In some cases were observed significant discrepancies between different studies. In the review are also shown the most important compounds of described essential oils. To the chemical components most commonly found as the main ingredients include β-caryophyllene (41 plants), linalool (27 plants), limonene (26), β-pinene (25), 1,8-cineole (22), carvacrol (21), α-pinene (21), p-cymene (20), γ-terpinene (20), and thymol (20).

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Sensitivity ofCandida albicansto essential oils: are they an alternative to antifungal agents?

Abstract: The results of this work support the research for new alternatives or complementary therapies against vaginal candidiasis.

Cited by 94 publications

References 62 publications

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

Essential oils from three species of Mentha harvested in Sardinia: chemical characterization and evaluation of their biological activity

New Tricks for Old Guys: Recent Developments in the Chemistry, Biochemistry, Applications and Exploitation of Selected Species from the Lamiaceae Family

Essential Oils of Lamiaceae Family Plants as Antifungals

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