Sensitivity of Human Conjunctival Tissue Cultures to Adenovirus 8, Herpes Simplex and Vaccinia Viruses. Induction of Resistance by an Interferon Inducer

The latent herpes simplex virus.

“…A wide range of agents and procedures which are able to inhibit or suppress HSV replication in vivo or in vitro with varying degrees of success have emerged (with others being added to the list continually). Noteworthy among these are: several antimitotic chemicals (253), cancer cell extracts (2), human gamma globulin (1), trifluorothymidine (261), trifluorodeoxyuridine (124), lysine (123), iododeoxycytidine (144), iododeoxyuridine (IudR or IDU; 56, 138, 261), polyinosinic-cytidylic acid (179,231,260), interferon (126), ara-c (109), ara-c with L-asparaginase (34), arabinofuranosyladenine (138,200), phosphonoacetic acid (238), adenine arabinoside (45,199), rifamycin (181), ethyl ether (186), various photodynamic dyes (1C4), X irradiation (7,139), a vaccinia virus vaccine (72), a herpesvirus vaccine (127, 251), cryotherapy (19,83,104), and psychotherapy (25). However, HSV has proven to be resistant to glutathione (124), fl-methazone (124), pyran copolymers (231), lysozyme (124), 6-azauridine (138), and kethoxal (256).…”

Inhibition of Herpesvirus hominis replication by human interferon

“…Members of the herpesvirus group are reported to be resistant to the antiviral activity of exogenous interferon in human cells when inhibition of cytopathic effect (CPE) is used to evaluate inhibition of virus replication (1,3,6). Others, however, have shown that herpesvirus CPE is inhibited by interferon inducers such as poly(I):poly(C) (8). Thus, the question of whether the herpesviruses are sensitive to the antiviral effects of interferon in a human cell system is not yet answered.…”