Sensitivity of different measures of frontal plane alignment to medial and lateral joint space narrowing: From the osteoarthritis initiative

Moyer, R.; Wirth, W.; Eckstein, F.

doi:10.1016/j.semarthrit.2015.06.015

Cited by 8 publications

(7 citation statements)

References 23 publications

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“…Differently, compared to WH women, WH men had lower risk of K-L grade worsening [ 30 ]. In evaluating the sensitivity of some radiographic measurements (femorotibial angle, FTA; hip–knee–ankle angle, HKA; goniometry) to medial and lateral JSN, the offset between FTA measures and HKA was larger in women than men [ 31 ]. As for femur morphometry, women had narrower and smaller femurs [ 32 , 33 , 34 ], reduced femoral offset values, but a greater valgus neck-shaft angle compared to men [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

123

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Many risk factors for osteoarthritis (OA) have been noted, while gender/sex differences have been understated. The work aimed to systematically review literature investigating as primary aim the relationship between gender/sex related discriminants and OA. The search was performed in PubMed, Science Direct and Web of Knowledge in the last 10 years. Inclusion criteria were limited to clinical studies of patients affected by OA in any joints, analyzing as primary aim gender/sex differences. Exclusion criteria were review articles, in vitro, in vivo and ex vivo studies, case series studies and papers in which gender/sex differences were adjusted as confounding variable. Of the 120 records screened, 42 studies were included. Different clinical outcomes were analyzed: morphometric differences, followed by kinematics, pain, functional outcomes after arthroplasty and health care needs of patients. Women appear to use more health care, have higher OA prevalence, clinical pain and inflammation, decreased cartilage volume, physical difficulty, and smaller joint parameters and dimensions, as compared to men. No in-depth studies or mechanistic studies analyzing biomarker differential expressions, molecular pathways and omic profiles were found that might drive preclinical and clinical research towards sex-/gender-oriented protocols.

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Section: Resultsmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

123

View full text Add to dashboard Cite

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“…The FTA measurement was defined using a coordinate system for identifying the distal aspect of the femoral condyles, based on anatomic landmarks for establishing a location-specific radiographic joint space width measurement (27,28). Previous work evaluating this method has shown that it is highly correlated with the hip-knee-ankle angle and predicts cartilage loss over 2 years as well as the gold standard (25,29,30). The femoral axis was defined to be perpendicular to the line tangent to the base of the femoral condyles.…”

Section: Methodsmentioning

confidence: 99%

“…Knee OA progression was defined as cartilage thickness loss exceeding the smallest detectable change (SDC) threshold in MFTC (2111mm) or LFTC (2121mm), respectively (23,31,33). Linear regression models were applied to FTA, adjusting for its varus distribution (25,29).…”

Section: More Negative Values Indicated Increased Varus Alignmentmentioning

confidence: 99%

Longitudinal Changes in Magnetic Resonance Imaging–Based Measures of Femorotibial Cartilage Thickness as a Function of Alignment and Obesity: Data From the Osteoarthritis Initiative

Moyer

Wirth

Eckstein

2017

Arthritis Care & Research

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Objective To investigate the interaction between malalignment and body mass index (BMI) on cartilage thickness change in patients with knee osteoarthritis (OA). Methods Femorotibial cartilage thickness was measured from baseline to 2 years in 558 knees with radiographic OA. Cartilage thickness was determined in the central weight-bearing medial femorotibial cartilage (cMFTC) and lateral (cLFTC) compartments. Femorotibial angle (FTA) was stratified into neutral, minor, and definite malalignment. BMI was stratified using World Health Organization classifications for normal, overweight, and obese. Multivariable linear regression models were used to investigate the interaction between alignment and BMI, adjusting for age, sex, and disease severity. Results There was no significant interaction for continuous measures of alignment and BMI (P = 0.301 for cMFTC and P = 0.852 for cLFTC). Using BMI tertiles, the association between alignment and medial or lateral cartilage thickness loss was not moderated by BMI, despite a significant association of malalignment with greater cartilage thickness loss (P ≤ 0.005). Using FTA tertiles, the association between BMI and medial cartilage thickness loss was approximately 3 times greater in knees with definite malalignment (P = 0.149) and approximately 5 times greater in knees with minor malalignment (P = 0.006). Specifically, knees with minor varus significantly modified this relationship (P = 0.021). Conclusion Malalignment was significantly associated with cartilage thickness loss per degree increase in malalignment, but was not moderated by BMI. BMI was significantly associated with greater rates of medial cartilage thickness loss per unit increase in BMI but only in knees with minor varus malalignment. These findings have implications for better understanding patient subgroups and intervention strategies targeting risk factors for knee OA.

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“…Neutral alignment was defined as a femorotibial angle of À5.9 to À1.9 in men and À6.8 to À2.8 in women, respectively. Malalignment was defined in either the varus (femorotibial angle < À5.9 for men and < À6.8 for women) or valgus (femorotibial angle > À1.9 for men and > À2.8 for women) directions 21,22 . KL grade of the contralateral knee assessed at baseline was also considered a potential risk factor for incident medial/lateral tibiofemoral ROA.…”

Section: Assessment Of Risk Factorsmentioning

confidence: 99%

Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: analysis of two prospective cohorts

Wei

Gross

Lane

et al. 2019

Osteoarthritis and Cartilage

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s u m m a r yObjective: To evaluate the etiologic heterogeneity between medial and lateral tibiofemoral radiographic osteoarthritis (ROA). Methods: Knees without medial or lateral tibiofemoral ROA at baseline were followed for 60-month in Multicenter Osteoarthritis Study (MOST) and for 48-month in Osteoarthritis Initiative (OAI). We examined the relation of previously reported risk factors to incident medial and lateral tibiofemoral ROA separately and determined the etiology heterogeneity with a ratio of rate ratios (RRs) (i.e., the RR for medial tibiofemoral ROA divided by the RR for lateral tibiofemoral ROA) using a duplication method for Cox proportional hazard regression. Results: Of 2,016 participants in MOST, 436 and 162 knees developed medial or lateral tibiofemoral ROA, respectively. Obesity and varus malalignment were 95% and 466% more strongly associated with incident medial tibiofemoral ROA than with lateral tibiofemoral ROA, respectively (ratios of RRs, 1.95 [95% confidence interval (CI):1.05e3.62] and 5.66 [95% CI:3.20e10.0]). In contrast, the associations of female sex and valgus malalignment with incident medial tibiofemoral ROA were weaker or in an opposite direction compared with lateral tibiofemoral Osteoarthritis (OA) (ratios of RRs, 0.40 [95% CI:0.26e0.63] and 0.20 [95% CI:0.12e0.34], respectively). Older age tended to show a weaker association with incident medial tibiofemoral ROA than with incident lateral tibiofemoral ROA. No heterogeneity was observed for the relation of race, knee injury, or contralateral knee ROA. These findings were closely replicated in OAI. Conclusion: Risk factor profiles for medial and lateral tibiofemoral ROA are different. These results can provide a framework for the development of targeted prevention and potential treatment strategies for specific knee OA subtypes.

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Sensitivity of different measures of frontal plane alignment to medial and lateral joint space narrowing: From the osteoarthritis initiative

Cited by 8 publications

References 23 publications

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Longitudinal Changes in Magnetic Resonance Imaging–Based Measures of Femorotibial Cartilage Thickness as a Function of Alignment and Obesity: Data From the Osteoarthritis Initiative

Risk factor heterogeneity for medial and lateral compartment knee osteoarthritis: analysis of two prospective cohorts

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