Sensitivity of Bronchial Responsiveness Measurements in Young Infants

Loland, Lotte; Buchvald, Frederik; Halkjær, Liselotte Brydensholt; Anhøj, Jacob; Hall, Graham L.; Persson, Tore; Krause, Tyra Grove; Bisgaard, Hans

doi:10.1378/chest.129.3.669

Cited by 29 publications

(29 citation statements)

References 42 publications

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“…Within-subject standard deviation (SDw) was calculated by dividing the difference of the symptom scores between the initial value and the value after saline challenge by the square-root of 2. The SD index was calculated as the difference between the symptom score following the challenge with the Der p 1 ( D. pteronyssinus allergen) dilution (TSS) and that following saline infusion (S 0 ), divided by SDw [18] : SD index = change in symptom score from post-allergen challenge measurement/SDw.…”

Section: Skin Prick Testmentioning

confidence: 99%

Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children Sensitized to House Dust Mites

Lee

et al. 2017

Int Arch Allergy Immunol

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Objective: The prevalence of local allergic rhinitis (LAR) in nonatopic children remains unknown. This study aimed to determine the prevalence, clinical characteristics, and severity of LAR in children in comparison to classical allergic rhinitis (AR) and nonallergic rhinitis (NAR). Study Design: A total of 145 children (aged 1-18 years) were enrolled and classified into 3 groups (AR, NAR, and LAR) based on a skin prick test (SPT) and a nasal provocation test (NPT) with house dust mite, i.e., Dermatophagoides pteronyssinus. NPT positivity was defined as a symptom score ≥2 standard deviations (SDs) above the healthy control score. Results: Eighty-one children had AR (55.9%), and 64 (44.1%) had symptoms of rhinitis with negative SPT; 59 NAR (40.7%) and 5 LAR (3.4%) children were identified. The κ score for agreement between the SPT and the NPT results was 0.778 (95% CI 0.726-0.830, p < 0.001). A significant correlation was observed between wheal diameter and maximum nasal symptom score provoked by D.pteronyssinus (rho = 0.589, p < 0.001). Nasal severity according to the ARIA guideline did not show any differences in the 3 groups (p = 0.693). The AR group was older than the LAR and NAR groups (AR > LAR > NAR, p = 0.003). Conclusions: Despite the evidence to support the existence of LAR in pediatric populations, we found that its prevalence was relatively low, possibly due to the high rate of agreement between SPT and NPT. Further investigations are needed to identify immunological as well as clinical implications of LAR.

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Section: Skin Prick Testmentioning

confidence: 99%

Prevalence and Clinical Characteristics of Local Allergic Rhinitis in Children Sensitized to House Dust Mites

Lee

et al. 2017

Int Arch Allergy Immunol

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“…10,11,[16][17][18] The forced expiratory volume at 0.5 second (FEV 0.5 ) from spirometry was chosen as the end-point for the baseline lung function on the basis of our previous sensitivity analyses. 10 The infant was sedated with an oral dose of chloral hydrate of 90 mg/kg and monitored continuously by pulse-oximetry for safety. A nonexpandable outer coat was wrapped around the infant's chest and abdomen with an inflatable balloon inside.…”

Section: Baseline Lung Function Testmentioning

confidence: 99%

“…10 After initial inhalation of saline, methacholine chloride was given in quadrupling dose steps from 0.04 to 16.67 mmol. The test procedure aimed at a 20% fall in FEV 0.5 or reaching the maximum dose; the median number of administered doses was 4.…”

Section: Methacholine Challengementioning

confidence: 99%

“…A 1-mg terbutaline pressurized metered-dose inhaler was administered via spacer at the end of the test. 10 Transcutaneous oxygen pressure Transcutaneous oxygen pressure (PtcO 2 ) after each dose step was used to determine bronchial responsiveness based on previous sensitivity analyses of known indices. PtcO 2 was measured continuously by the TCM3 from Radiometer, Copenhagen, Denmark.…”

Section: Methacholine Challengementioning

confidence: 99%

“…10,11 The objective of this study was to identify prenatal determinants for the neonatal baseline lung function and bronchial responsiveness. The study is reported in accordance with recognized guidelines for observational studies.…”

mentioning

confidence: 99%

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