Sensitivity limits of biosensors used for the detection of metals in drinking water

Kanellis, Vangelis George

doi:10.1007/s12551-018-0457-9

Cited by 13 publications

(5 citation statements)

References 134 publications

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“…For instance, matrix interferences in the colorimetric method either disrupt the reaction between the reagent and the analyte or interfere the spectrometric light measurement [ 21 ]. In the biosensing method, more complex biological molecules, e.g., Daphnia magna, are needed with higher selectivity and less interference for reagents [ 26 ]. In the electrochemical sensing technique, lead-selective membranes are utilized on electrodes, where the response can be impacted by the interference from other ions presented in the water sample, effecting the solution ionic strength and potential drift [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Highly-Efficient Sulfonated UiO-66(Zr) Optical Fiber for Rapid Detection of Trace Levels of Pb2+

Nazari

Amini

Eden

et al. 2021

IJMS

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Lead detection for biological environments, aqueous resources, and medicinal compounds, rely mainly on either utilizing bulky lab equipment such as ICP-OES or ready-made sensors, which are based on colorimetry with some limitations including selectivity and low interference. Remote, rapid and efficient detection of heavy metals in aqueous solutions at ppm and sub-ppm levels have faced significant challenges that requires novel compounds with such ability. Here, a UiO-66(Zr) metal-organic framework (MOF) functionalized with SO3H group (SO3H-UiO-66(Zr)) is deposited on the end-face of an optical fiber to detect lead cations (Pb2+) in water at 25.2, 43.5 and 64.0 ppm levels. The SO3H-UiO-66(Zr) system provides a Fabry–Perot sensor by which the lead ions are detected rapidly (milliseconds) at 25.2 ppm aqueous solution reflecting in the wavelength shifts in interference spectrum. The proposed removal mechanism is based on the adsorption of [Pb(OH2)6]2+ in water on SO3H-UiO-66(Zr) due to a strong affinity between functionalized MOF and lead. This is the first work that advances a multi-purpose optical fiber-coated functional MOF as an on-site remote chemical sensor for rapid detection of lead cations at extremely low concentrations in an aqueous system.

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Section: Introductionmentioning

confidence: 99%

Highly-Efficient Sulfonated UiO-66(Zr) Optical Fiber for Rapid Detection of Trace Levels of Pb2+

Nazari

Amini

Eden

et al. 2021

IJMS

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“…The response of the Cu biosensor AE1239 was quantified using a multimode microplate reader (CLARIOstar R , BMG Labtech). This strain has a reported detection limit of 1 µM (Kanellis, 2018). AE1239 cultures were prepared by growing them in MM284 for 72 h at 30 • C, subsequently washing them twice with filter-sterilized mineral water (Ordal) and resuspending them in either filter-sterilized mineral water or MM284.…”

Section: Biosensor Experimentsmentioning

confidence: 99%

Copper Resistance Mediates Long-Term Survival of Cupriavidus metallidurans in Wet Contact With Metallic Copper

et al. 2020

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“…People with special training have to carry out these processes [ 14 , 15 , 16 ]. Chemical sensors display great efficiency in detecting mercury ions due to their biocompatibility, portability, and promise for use in field treatments [ 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing

et al. 2022

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We developed a new optical sensor for tracing Hg(II) ions. The detection affinity examines within a concentration range of 0–4.0 µM Hg(II). The sensor film is based on Methyl 2-hydroxy-3-(((2S,2’R,3a’S,5R)-2-isopropyl-5,5’-dimethyl-4’-oxotetrahydro-2’H-spiro[cy-clohexane-1,6’-im-idazo[1,5-b]isoxazol]-2’-yl)methyl)-5-methylbenzoate (IXZD). The novel synthesized compound could be utilized as an optical turn-on chemosensor for pH. The emission intensity is highly enhanced for the deprotonated form concerning the protonated form. IXZD probe has a characteristic fluorescence peak at 481 nm under excitation of 351 nm with large Stocks shift of approximately 130 nm. In addition, the binding process of IXZD:Hg(II) presents a 1:1 molar ratio which is proved by the large quench of the 481 nm emission peak of IXZD and the growth of a new emission peak at 399 nm (blue shift). The binding configurations with one Hg(II) cation and its electronic characteristics were investigated by applying the Density Functional Theory (DFT) and the time-dependent DFT (TDDFT) calculations. Density functional theory (DFT) and the time-dependent DFT (TDDFT) theoretical results were provided to examine Hg(II)-IXZD structures and their electronic properties in solution. The developed chemical sensor was offered based on the intramolecular charge transfer (ICT) mechanism. The sensor film has a significantly low limit of detection (LOD) for Hg(II) of 0.025 μM in pH 7.4, with a relative standard deviation RSDr (1%, n = 3). Lastly, the IXZD shows effective binding affinity to mercury ions, and the binding constant Kb was estimated to be 5.80 × 105 M−1. Hence, this developed optical sensor film has a significant efficiency for tracing mercury ions based on IXZD molecule-doped sensor film.

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Sensitivity limits of biosensors used for the detection of metals in drinking water

Cited by 13 publications

References 134 publications

Highly-Efficient Sulfonated UiO-66(Zr) Optical Fiber for Rapid Detection of Trace Levels of Pb2+

Highly-Efficient Sulfonated UiO-66(Zr) Optical Fiber for Rapid Detection of Trace Levels of Pb2+

Copper Resistance Mediates Long-Term Survival of Cupriavidus metallidurans in Wet Contact With Metallic Copper

A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing

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