Sensitivity enhancement of fiber-laser-based stimulated Raman scattering microscopy by collinear balanced detection technique

Nose, Keisuke; Ozeki, Yasuyuki; Kishi, Takashi; Sumimura, Kazuhiko; Nishizawa, Norihiko; Fukui, Kiichi; Kanematsu, Yasuo; Itoh, Kazuyoshi

doi:10.1364/oe.20.013958

Cited by 77 publications

(74 citation statements)

References 32 publications

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“…The intensity noises were measured by a photodetector and an RF spectrum analyzer (SA). We can see that the intensity noise can be reduced by CBD down to the shot noise limit.Note that shot-noise-limited intensity noise itself was previously reported in [5]. Nevertheless, bulky DAL with free-space optics was used therein.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, there are two important research trends in SRS microscopy. One is the development of fiber laser (FL)-based pulse sources for realizing compact and practical systems [4,5]. The other one is the enhancement of molecular specificity by employing spectral imaging [6,7] and spectral analysis [8].…”

Section: Introductionmentioning

confidence: 99%

“…This excess intensity noise limits the signal-to-noise ratio (SNR) in SRS microscopy. To cope with this, we previously reported that the intensity noise level can be reduced down to the shot noise limit by means of collinear balanced detection (CBD) technique [5].…”

Section: Introductionmentioning

confidence: 99%

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Fiber-laser-based Stimulated Raman microspectroscopy with shot-noise limited sensitivity

Nose

Kishi

Ozeki

et al. 2013

2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR)

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fiber-laser-based Stimulated Raman microspectroscopy with shot-noise limited sensitivity

Nose

Kishi

Ozeki

et al. 2013

2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEOPR)

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“…Certain balanced detection methods [26,33,34,35] offer other ways of cancellation of the optical intensity noise on a probe beam. In these methods, a reference beam is prepared from the same beam source as that of the probe beam, and the detected signal of the reference beam is subtracted from that of the probe beam.…”

Section: B Noise Cancellation Performance On Optical Splitting Ratiomentioning

confidence: 99%

Noise cancellation with phase-detection technique for pump-probe measurement and application to stimulated Raman imaging

et al. 2015

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Intensity noise on a probe beam is a serious obstacle to highly sensitive and high-speed pump-probe microscopy. In this report, a reference beam of the probe is prepared and delayed. The intensity modulation by the sample is measured as the phase modulation of the superposition of detected electrical signals of the probe and reference beams, and the intensity noise is canceled. We evaluate performance of the noise cancellation using the super-continuum light from a piece of photonic crystal fiber, and find that the noise is canceled by ∼26 dB. We then apply the method to a stimulated Raman microscope. This method contributes to highly sensitive and high-speed pump-probe imaging with various light sources.

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“…55 Fiber sources have been successfully demonstrated for CARS microscopy [56][57][58] and, in combination with balanced detection techniques, have also signaled their potential for SRS imaging. 59 …”

Section: Light Sourcesmentioning

confidence: 99%

Biological imaging with coherent Raman scattering microscopy: a tutorial

et al. 2014

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Coherent Raman scattering (CRS) microscopy is gaining acceptance as a valuable addition to the imaging toolset of biological researchers. Optimal use of this label-free imaging technique benefits from a basic understanding of the physical principles and technical merits of the CRS microscope. This tutorial offers qualitative explanations of the principles behind CRS microscopy and provides information about the applicability of this nonlinear optical imaging approach for biological research.

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Sensitivity enhancement of fiber-laser-based stimulated Raman scattering microscopy by collinear balanced detection technique

Cited by 77 publications

References 32 publications

Fiber-laser-based Stimulated Raman microspectroscopy with shot-noise limited sensitivity

Fiber-laser-based Stimulated Raman microspectroscopy with shot-noise limited sensitivity

Noise cancellation with phase-detection technique for pump-probe measurement and application to stimulated Raman imaging

Biological imaging with coherent Raman scattering microscopy: a tutorial

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