Sensitivity dependence of Hall biosensor arrays with the position of superparamagnetic beads on their active regions

Abstract

Articles you may be interested inHigh sensitivity and multifunctional micro-Hall sensors fabricated using InAlSb/InAsSb/InAlSb heterostructures J. Appl. Phys. 105, 07E909 (2009); 10.1063/1.3074513Second-generation quantum-well sensors for room-temperature scanning Hall probe microscopy This paper describes a numerical and experimental analysis on the variation of the magnetic sensitivity of the active surface region of AlGaAs/ InGaAs two dimensional electron gas Hall effect biosensors with location and number of superparamagnetic beads. Experiments were conducted using linear arrays of devices consisting of ten sensors each with an area of 5 ϫ 5 m 2 . The edges and corners of the Hall sensors were most sensitive and exhibited a linear response. These results are important for commercialization of high sensitivity Hall effect biosensors with a wide dynamic range.

Magnetic biosensor technologies for medical applications: a review

“…[162] in which an array of such Hall crosses indicated the feasibility for multiplexed detection, while a 30 9 30 lm InSb sensor successfully detected 200 nm diameter particles. A recent comparative study on different materials suitable for Hall biosensors [145] concluded that sensors based on semiconductor heterojunctions, such as InAs-AlGaSb, show the highest sensitivity, particularly for the case that beads can be localised to the edges of the device which permits quantitative bead detection [83].…”

Magnetic biosensors: Modelling and simulation

“…This can be understood as being due to the local character of the particle stray fields. Kumagai et al(Kumagai et al 2008) have proposed a numerical and experimental analysis on the variation of the magnetic sensitivity of the active surface region of AlGaAs/InGaAs two-dimensional electron gas Hall effect biosensors with location and number of superparamagnetic beads. Detection procedure of superparamagnetic beads with diameters in the range of 200 nm to 2.8 µm using Hall sensors and lock-in measurements has been already reported in a previous work.…”

Quantification of Magnetic Nanobeads With Micrometer Hall Sensors

“…The simultaneous detection of multiple microbeads was achieved by using InSb and AlGaAs/InGaAs sensor arrays consisting of a succession of Hall probes with 5 m size [16,17]. An 8192 element Hall sensor array was also developed, enabling the quantification of 1% surface coverage of 2.8 μm beads [18].…”