Sensitivity and variability of Presage dosimeter formulations in sheet form with application to SBRT and SRS QA

Dumas, Michael; Rakowski, J

doi:10.1118/1.4936104

Cited by 6 publications

(18 citation statements)

References 22 publications

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“…Dumas and Rakowski noted issues with the use of the Epson flatbed scanner, citing difficulty obtaining clear readout scans due to the presence of bubbles and sheet irregularities and concern with UV light exposure to the sheets from the Epson scanner . They also reported poor dose resolution and low sensitivity, resulting in a poor signal to noise ratio.…”

Section: Resultsmentioning

confidence: 99%

“…Recent work by Dumas and Rakowski introduced a sheet form of single‐use in‐house manufactured Presage and evaluated it in the context of applications for radiosurgery QA . The sheets were 1 mm thick and compatible with readout by a flat‐bed‐scanner.…”

Section: Introductionmentioning

confidence: 99%

“…7 Recent work by Dumas and Rakowski introduced a sheet form of single-use in-house manufactured Presage and evaluated it in the context of applications for radiosurgery QA. 8 The sheets were 1 mm thick and compatible with readout by a flat-bed-scanner. Dumas and Rakowski conclude that the single use sheets can be an effective quality assurance tool for SRS and SBRT.…”

Section: Introductionmentioning

confidence: 99%

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An investigation of a novel reusable radiochromic sheet for 2D dose measurement

et al. 2019

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Purpose Radiochromic film remains a useful and versatile clinical dosimetry tool. Current film options are single use. Here, we introduce a novel prototype two‐dimensional (2D) radiochromic sheet, which optically clears naturally at room temperature after irradiation and can be reused. We evaluate the sheets for potential as a 2D dosimeter and as a radiochromic bolus with capability for dose measurement. Methods A novel derivative of reusable Presage® was manufactured into thin sheets of 5 mm thickness. The sheets contained 2% cumin‐leucomalachitegreen‐diethylamine (LMG‐DEA) and plasticizer (up to 25% by weight). Irradiation experiments were performed to characterize the response to megavoltage radiation, including dose sensitivity, temporal decay rate, consistency of repeat irradiations, intra and inter‐sheet reproducibility, multi‐modality response (electrons and photons), and temperature sensitivity (22°C to 36°C). The local change in optical‐density (ΔOD), before and after radiation, was obtained with a flat‐bed film scanner and extracting the red channel. Repeat scanning enabled investigation of the temporal decay of ΔOD. Additional studies investigated clinical utility of the sheets through application to IMRT treatment plans (prostate and a TG119 commissioning plan), and a chest wall electron boost treatment. In the latter test, the sheet performed as a radiochromic bolus. Results The radiation induced OD change in the sheets was found to be proportional to dose and to exponentially decay to baseline in ~24 h (R2 = 0.9986). The sheet could be reused and had similar sensitivity (within 1% after the first irradiation) for at least eight irradiations. Importantly, no memory of previous irradiations was observed within measurement uncertainty. The consistency of dose response from photons (6 and 15 MV) and electrons (6–20 MeV) was found to be within calibration uncertainty (~1%). The dose sensitivity of the sheets had a temperature dependence of 0.0012 ΔOD/°C. For the short (1 min) single field IMRT QA verification, good agreement was observed between the Presage sheet and EBT film (gamma pass rate 97% at 3% 3 mm dose‐difference and distance‐to‐agreement tolerance, with a 10% threshold). For the longer (~13 min) TG‐119 9‐field IMRT verification the gamma agreement was lower at 93% pass rate at 5% 3 mm, 10% threshold, when compared with Eclipse. The lower rate is attributed to uncertainty arising from signal decay during irradiation and indicates a current limitation. For the electron cutout treatment, both Presage and EBT agreed well (within 2% RMS difference) but differed from the Eclipse treatment plan (~7% RMS difference) indicating some limitations to the Eclipse modeling in this case. The worst case estimates of uncertainty introduced by the signal decay for deliveries of 2, 5, and 10 min are 0.6%, 1.4%, and 2.8% respectively. Conclusions Reusable Presage sheets show promise for 2D dose measurement and as a radiochromic bolus for in vivo dose measurement. The current prototype is suitable for deliveries o...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An investigation of a novel reusable radiochromic sheet for 2D dose measurement

et al. 2019

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“…In 2015, a published study by Dumas et al shows the potential use of PRESAGE sheets for dosimetry. 8 However, in the study, the sensitivity, signal to noise ratio, and temporal stability of the PRESAGE sheets with a different formulation were insufficient for its use in clinical applications. Furthermore, this study did not provide a comprehensive dosimetric characterization of the sheets.…”

Section: Introductionmentioning

confidence: 97%

“…Therefore, unlike radiochromic film, the accuracy of the measurements does not heavily depend on the calibration process. In 2015, a published study by Dumas et al shows the potential use of PRESAGE sheets for dosimetry . However, in the study, the sensitivity, signal to noise ratio, and temporal stability of the PRESAGE sheets with a different formulation were insufficient for its use in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric characterization of a body‐conforming radiochromic sheet

Wang

Dona

Liu

et al. 2020

J Applied Clin Med Phys

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Purpose A novel radiochromic PRESAGE sheet (Heuris Inc.) with 3 mm thickness has been developed as a measurement tool for 2D dosimetry. Its inherent ability to conform to irregular surfaces makes this dosimeter advantageous for patient surface dosimetry. This study is a comprehensive investigation into the PRESAGE sheet’s dosimetric characteristic, accuracy and its potential use as a dosimeter for clinical applications. Methods The characterization of the dosimeter included evaluation of the temporal stability of the dose linearity, reproducibility, measurement uncertainties, dose rate, energy, temperature and angular dependence, lateral response artifacts, percent depth dose curve, and 2D dose measurement. Dose distribution measurements were acquired for regular square fields on a flat and irregular surface and an irregular modulated field on the smooth surface. All measurements were performed using an Epson 11000XL high‐resolution scanner. Results The examined dosimeters exhibit stable linear response, standard error of repeated measurements within 2%, negligible dose rate, energy, and angular dependence. The same linear dose response was measured while the dosimeter was in contact with a heated water surface. Gamma test and histogram analysis of the dose difference between PRESAGE and EBT3 film, PRESAGE and the treatment planning system (TPS) were used to evaluate the measured dose distributions. The PRESAGE sheet dose distributions showed good agreement with EBT3 film and TPS. A discrepancy smaller than the statistical error of the two dosimeters was reported. Conclusions This study established a full dosimetric characterization of the PRESAGE sheets with the purpose of laying the foundation for future clinical uses. The results presented here for the comparison of this novel dosimeter with those currently in use reinforce the possibility of using this dosimeter as an alternative for irregular surface dose measurements.

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Flexible film dosimeter for in vivo dosimetry

et al. 2020

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The aims of this study were to develop a flexible film dosimeter applicable to the irregular surface of a patient for in vivo dosimetry and to evaluate the device's dosimetric characteristics. Methods: A flexible film dosimeter with active layers consisting of radiochromic-sensitive films and flexible silicone materials was constructed. The dose-response, sensitivity, scanning orientation dependence, energy dependence, and dose rate dependence of the flexible film dosimeter were tested. Irradiated dosimeters were scanned 24 h post-irradiation, and the region of interest was 5 mm 9 5 mm. Biological stability tests ensured the safety of application of the flexible film dosimeter for patients. A preliminary clinical study with the flexible film dosimeter was implemented on four patients. Results: The red channel demonstrated the highest sensitivity among all channels, and the response sensitivity of the dosimeter decreased with the applied dose, which were the same as the characteristics of GAFCHROMIC EBT3 radiochromic films. The flexible film dosimeter showed no significant energy dependence for photon beams of 6 MV, 6 MV flattening filter-free (FFF), 10 MV, and 15 MV. The flexible film dosimeter showed no substantial dose rate dependence with 6 or 6 MV FFF. In terms of biological stability, the flexible film dosimeter demonstrated no cytotoxicity, no irritation, and no skin sensitization. In the preliminary clinical study, the dose differences between the measurements with the flexible film dosimeter and calculations with the treatment planning system ranged from À0.1% to 1.2% for all patients. Conclusions: The dosimeter developed in this study is a flexible film capable of attachment to a curved skin surface. The biological test results indicate the stability of the flexible film dosimeter. The preliminary clinical study showed that the flexible film dosimeter can be successfully applied as an in vivo dosimeter.

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Sensitivity and variability of Presage dosimeter formulations in sheet form with application to SBRT and SRS QA

Cited by 6 publications

References 22 publications

An investigation of a novel reusable radiochromic sheet for 2D dose measurement

An investigation of a novel reusable radiochromic sheet for 2D dose measurement

Dosimetric characterization of a body‐conforming radiochromic sheet

Flexible film dosimeter for in vivo dosimetry

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