Sensitivity and specificity of urinary and serum neurotrophins in the diagnosis of neurogenic detrusor overactivity in multiple  sclerosis

Баженов, И. В.; Филиппова, Е. С.; Базарный, В. В.; Сазонов, С. В.; Volkova, L. I.; Zaitseva, L N

doi:10.18565/urology.2018.2.44-48

Cited by 3 publications

(4 citation statements)

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“…The authors concluded that NGF is a very specific biomarker, while BDNF is very sensitive. Therefore, the most valuable will be the combination of both measurements—serum NGF and BDNF [ 32 ]. In our study, we did not observe any differences in baseline NGF levels or changes following whole body cryotherapy ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

et al. 2022

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The aim of the study was to compare the effect of a series of 20 whole body cryotherapy (WBC) sessions on iron levels and neuroplasticity biomarkers in women with multiple sclerosis (MS) and healthy women. Consent was obtained from the Bioethics Committee at the Regional Medical Chamber in Krakow (87/KBL/OIL/2018; 8 May 2018). The study was registered in the Australian New Zealand Clinical Trials Registry (ACTRN12620001142921; 2 November 2020). The study included 30 people: 15 women with multiple sclerosis (mean age 41.53 ± 6.98 years) and 15 healthy women (mean age 38.47 ± 6.0 years). Both groups attended cryotherapy sessions. Venous blood was collected for analysis before the WBC session and after 20 sessions. In women with MS and healthy women, no significant effect of WBC on changes in the level biomarkers of neuroplasticity was found. There were also no statistically significant differences between the groups of the analyzed indices at the beginning of the study.

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Section: Discussionmentioning

confidence: 99%

Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

et al. 2022

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“…Some authors demonstrated increased NGF levels in patients with idiopathic detrusor overactivity and its reduction as a result of the anticholinergic therapy 13‐16 . The clinical changes of NGF levels in neurogenic bladder patients are less explored 5,7 ; the same applies to the role of BDNF 17‐19 …”

Section: Discussionmentioning

confidence: 99%

“…12,13 Some authors demonstrated increased NGF levels in patients with idiopathic detrusor overactivity and its reduction as a result of the anticholinergic therapy. [13][14][15][16] The clinical changes of NGF levels in neurogenic bladder patients are less explored 5,7 ; the same applies to the role of BDNF. [17][18][19] We attempted to clarify the clinical usefulness of neurotrophins as biomarkers of BoNTA injections efficacy in patients with neurogenic bladder.…”

Section: Discussionmentioning

confidence: 99%

“…In our earlier study of urinary and serum NGF and BDNF levels in MS patients with NDO, we recorded overexpression of NGF receptors in bladder mucosa and demonstrated the clinical relevance of neurotrophins as NDO biomarkers. 7 There are no data on the impact of different treatment protocols on neurotrophin levels in the MS population or on their correlation with urodynamic improvement.…”

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confidence: 99%

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Impact of intradetrusor botulinum toxin A injections on serum and urinary concentrations of nerve growth factor and brain‐derived neurotrophic factor in patients with multiple sclerosis and neurogenic detrusor overactivity

Филиппова

Баженов

Ziryanov

et al. 2020

Neurourology and Urodynamics

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Aims: To evaluate the practical relevance of changes in serum and urinary neurotrophins levels in patients with multiple sclerosis (MS) and neurogenic lower urinary tract dysfunction (NLUTD) after intradetrusor injections of botulinum toxin A (BoNTA). Methods: The study included 36 patients with MS and NLUTD and 20 controls. The patients with NLUTD received intradetrusor injection of BoNTA (200 U). The nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels were measured in serum and urine at baseline and then at 1, 3, and 6 months by enzyme-linked immunosorbent assay. Urinary NGF and BDNF were normalized to creatinine (NGF/Cr, BDNF/Cr). Patients' assessment included urodynamic examination and Neurogenic Bladder Symptom Score (NBSS). Results: After BoNTA injections, no significant changes were observed in the serum NGF and BDNF or the urinary BDNF/Cr. The urinary NGF/Cr was significantly higher in MS patients (1.23 ± 0.34) at baseline compared with controls (0.084 ± 0.02; p = .021). The urinary NGF/Cr decreased to 0.51 ± 0.12 (p = .001) and 0.53 ± 0.32 (p = .005) at 1 and 3 months, increasing to 1.12 ± 0.49 (p = .003) at 6 months. The urinary NGF/Cr level at baseline demonstrated a low diagnostic accuracy in predicting a better response to the BoNTA treatment (area under the curve = 0.661; p = .047) and no correlation with the urodynamic parameters. Conclusions: The urinary NGF/Cr at baseline or its reduction at the first month following treatment does not serve as a predictor for the response to the BoNTA injections or for urodynamic changes.

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Plasma levels of nerve growth factor in Egyptian autistic children: Relation to hyperserotonemia and autoimmunity

Mostafa

Meguid

Shehab

et al. 2021

Journal of Neuroimmunology

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Sensitivity and specificity of urinary and serum neurotrophins in the diagnosis of neurogenic detrusor overactivity in multiple sclerosis

Cited by 3 publications

References 0 publications

Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

Impact of intradetrusor botulinum toxin A injections on serum and urinary concentrations of nerve growth factor and brain‐derived neurotrophic factor in patients with multiple sclerosis and neurogenic detrusor overactivity

Plasma levels of nerve growth factor in Egyptian autistic children: Relation to hyperserotonemia and autoimmunity

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